Copyright
©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 21, 2015; 21(23): 7233-7241
Published online Jun 21, 2015. doi: 10.3748/wjg.v21.i23.7233
Published online Jun 21, 2015. doi: 10.3748/wjg.v21.i23.7233
PillCam COLON 2© in Crohn’s disease: A new concept of pan-enteric mucosal healing assessment
Pedro Boal Carvalho, Bruno Rosa, Francisca Dias de Castro, Maria João Moreira, José Cotter, Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, 4710-057 Braga, Portugal
Pedro Boal Carvalho, Bruno Rosa, Francisca Dias de Castro, Maria João Moreira, José Cotter, ICVS/3B’s, PT Government Associate Laboratory, 4710-057 Guimarães/Braga, Portugal
Pedro Boal Carvalho, Bruno Rosa, Francisca Dias de Castro, Maria João Moreira, José Cotter, Gastroenterology Department, Centro Hospitalar do Alto Ave, 4831-044 Guimarães, Portugal
Author contributions: Boal Carvalho P performed the study, data analysis, and a literature search and drafted the manuscript; Rosa B participated in the design of the study and reviewed the capsule endoscopies; Dias de Castro D participated in the design of the study and performed statistical analysis; Moreira MJ revised the manuscript and reviewed the capsule endoscopies; Cotter J participated in the design of the study, critically revised the manuscript and approved the final version to be submitted.
Ethics approval: The study was reviewed and approved by the Centro Hospitalar do Alto Ave Institutional Review Board.
Informed consent: All patients provided written consent to undergo total colonoscopy, small bowel capsule endoscopy and pan-enteric endoscopy with PCC2.
Conflict-of-interest: The authors have no conflict of interests regarding this manuscript.
Data sharing: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Pedro Boal Carvalho, MD, Gastroenterology Department, Centro Hospitalar do Alto Ave, Guimarães, Rua dos Cutileiros, Creixomil, 4831-044 Guimarães, Portugal. pedroboalcarvalho@chaa.min-saude.pt
Telephone: +351-253-540330 Fax: +351-253-513592
Received: January 11, 2015
Peer-review started: January 11, 2015
First decision: February 10, 2015
Revised: February 27, 2015
Accepted: April 17, 2015
Article in press: April 17, 2015
Published online: June 21, 2015
Processing time: 160 Days and 11.4 Hours
Peer-review started: January 11, 2015
First decision: February 10, 2015
Revised: February 27, 2015
Accepted: April 17, 2015
Article in press: April 17, 2015
Published online: June 21, 2015
Processing time: 160 Days and 11.4 Hours
Core Tip
Core tip: Our study reports for the first time the use of PillCam COLON2 Capsule (PCC2) to evaluate mucosal healing of the entire intestinal tract in small bowel plus colonic Crohn’s disease. Only 25% of our patients in corticosteroid-free clinical remission achieved mucosal healing in both the small bowel and the colon, while in 42% there was disease activity limited to either the small bowel or the colon. Endoscopic evaluation of the entire gastrointestinal tract with PCC2 was both feasible and safe. Our results highlight the limitations of clinical assessment when stratifying disease activity and emphasize the need for pan-enteric endoscopy in order to guide therapeutic adjustment.