Sequential blood purification therapy for critical patients with hyperlipidemic severe acute pancreatitis

Table 1 Baseline characteristics of patients in the two groups

Characteristic	Study group(n = 15)	Control group(n = 16)	P value
Age (yr)	42.6 ± 9.9	40.9 ± 12.6	0.6806
BMI (kg/m2)	27.4 ± 4.1	28.5 ± 3.7	0.4387
Sex (male/female), n	10/5	11/5	1.0000
Bacterial culture positive, n	3	4	1.0000
Marshall score	2.6 ± 1.7	2.5 ± 1.4	0.8590
APACHE II score	21.3 ± 2.9	22.5 ± 2.1	0.1952
Upper gastrointestinal bleeding, n	7	8	1.0000
ARDS, n	12	13	1.0000
Heart failure/pulmonary edema, n	3	2	0.6539
DIC, n	1	2	1.0000
Surgical debridement, n	1	1	1.0000
Use of vasopressors, n	15	16	1.0000
Mechanical ventilation, n	10	10	1.0000

ARDS: Acute respiratory distress syndrome; BMI: Body mass index; DIC: Disseminated intravascular coagulation.

Table 2 Comparison of secondary outcome measures

Variable	Study group	Control group	P value
Duration of ICU stay (d)	7.40 ± 1.35	9.19 ± 2.99	0.0420
Time to target TG (d)	3.47 ± 0.52	7.90 ± 1.14	< 0.0001
Systemic complications, n (%)	9 (60.00)	8 (50.00)	0.7224
Local complications, n (%)	12 (80.00)	13 (81.25)	1.0000

ICU: Intensive care unit; TG: Triglyceride level.

Table 3 Comparison of physiologic variables

Variable	Study group(n = 15)	Control group(n = 16)
Body temperature (°C)	37.5 ± 0.6	37.3 ± 0.4
Heart rate (beats/min)	86 ± 14	90 ± 19
RR interval (beats/min)	16 ± 4	18 ± 5
Mean arterial pressure (mmHg)	70.2 ± 9.3	67.9 ± 6.0
PaO2/FiO2	179.1 ± 41.9	167.7 ± 38.9

Table 4 Comparison of laboratory variables

Variable	Study group (n = 15)	Control group (n = 16)
WBC (109/L)	11.5 ± 2.3	13.1 ± 2.9
PLT (109/L)	196.5 ± 40.5	199.6 ± 58.7
ALB (g/L)	37.8 ± 4.6a	38.9 ± 5.7
ALT (U/L)	54.3 ± 20.4	59.7 ± 23.1
TBIL (mmol/L)	20.1 ± 3.9	25.3 ± 4.2
BUN (mmol/L)	7.8 ± 2.6	9.7 ± 2.8
Scr (mmol/L)	149.8 ± 30.2	139.3 ± 37.5
Ca2+ (mmol/L)	2.1 ± 0.5	2.0 ± 0.3
Serum amylase (U/L)	74.4 ± 28.3	82.1 ± 20.7
Urine amylase (U/L)	399.7 ± 59.7	387.1 ± 51.4
CRP (mg/L)	20.5 ± 6.4a	28.5 ± 7.1
PCT (ng/mL)	1.33 ± 0.42a	1.71 ± 0.61

^aP < 0.05 vs control group. ALB: Albumin; ALT: Alanine transaminase; BUN: Urea nitrogen; CRP: C-reactive protein; PCT: Procalcitonin; PLT: Platelet; Scr: Serum creatinine; TBIL: Total bilirubin; WBC: White blood cell.