Primary hepatic angiosarcoma: A report of two cases and literature review

Table 1 Summary of patients with primary hepatic angiosarcoma

Ref.	n	Age (yr) (median)	Sex (M/F)	Clinical manifestations	Tumor characteristics (n)	Extrahepatic metastasis	Tumor rupture	Treatment	Surgical margin	Survival time
Kim et al[10]	5	41-69 (45)	5/0	Right upper abdominal pain, leg edema, hemoptysis, ascites, chest discomfort, DOE	Multiple nodules (5)	Spleen (2), lung (1), pericardium (1), bone (1)	1	Palliative chemotherapy (4)	/	86 d (m)1
Yin et al[11]	7	34-71 (52)	6/1	Abdominal pain, jaundice, ascites, anemia, chest pain, edema, weight loss	NS	Spleen (1), lung (2), bone (1)	None	Hepatectomy + chemotherapy (3), chemotherapy (2)	NS	89.9 d (m)1 (13-238 d), of hepatectomy + chemotherapy: 94 d (m)1
López et al[36]	2	20, 31	2/0	Acute liver failure	Diffuse micronodules (1), multiple nodules (1)	NS	None	Transplantation + chemotherapy (1), Conservative therapy (1)	/	2 mo, 17 d
Egea Valenzuela et al[15]	2	65, 73	2/0	Jaundice, abdominal distension, bleeding tendency	Multiple nodules (2)	None	None	Conservative therapy	/	36 h, several days
Matthaei et al[13]	5	20-80 (56)	3/2	NS	Dominant mass (5)	Lung (3), peritoneum (1)	None	Hepatectomy	R0 (4), R (1)	30 mo (m)1, 1 alive with recurrence (R0), 1 no evidence of recurrence (R0)
Yang et al[37]	1	70	1/0	Asymptomatic	Multiple nodules	None	None	Conservative therapy	/	6 mo
Park et al[12]	6	29-80 (59.5)	5/1	Abdominal pain, fever, abdominal distension, hematuria, anemia	Dominant mass and/or intrahepatic nodules(6)	Spleen (1)	3	TACE (4), TAE (2)	/	3.5 mo (m)1
Bruegel et al[14]	7	51-78 (65)	4/3	Abdominal pain, weight loss, fatigue, jaundice	Dominant mass (1), multiple nodules (6)	Spleen (1), bone (3), lung (2), cerebellum (1) retroperitoneum (2)	1	Hepatectomy + chemotherapy(1), hepatectomy (1), chemotherapy(4)	NS	16 mo (m)1

¹Represents median survival time. DOE: Dyspnea on exertion; NS: Not specified; R0: No residual tumor; R1: Microscopic residual tumor; M: Male; F: Female.