Models for predicting hepatitis B e antigen seroconversion in response to interferon-&alpha; in chronic hepatitis B patients

doi:10.3748/wjg.v21.i18.5668

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. May 14, 2015; 21(18): 5668-5676
Published online May 14, 2015. doi: 10.3748/wjg.v21.i18.5668

Table 1 Individual factors of patients with diverse responses at 52 wk after interferon-α therapy n (%)

Characteristic	Total (n = 147)	RS (n = 47)	NRS (n = 100)
Sex
Male	106 (72.1)	33 (70.2)	73 (73.0)
Female	41 (27.9)	14 (29.8)	27 (27.0)
Age (yr)	25.02 ± 056	26.40 ± 1.19	24.37 ± 0.59
ALT (U/L)	214.25 ± 17.38	226.23 ± 19.19	208.62 ± 23.94
HBV DNA
(log₁₀ copies/mL)	7.16 ± 0.07	6.93 ± 0.14	7.27 ± 0.09
HBsAg
(log₁₀ IU/mL)	4.11 ± 0.07	3.93 ± 0.14	4.20 ± 0.07
HBeAg
(log₁₀ S/CO)	2.55 ± 0.07	2.30 ± 0.13^a	2.67 ± 0.07^a
Anti-HBc (S/CO)	11.13 ± 0.15	11.54 ± 0.27	10.94 ± 0.17
Genotype
B	85 (57.8)	26 (55.3)	59 (59.0)
C	55 (37.4)	21 (44.7)	34 (34.0)
Other	7 (4.8)	0 (0.0)	7 (7.0)

Data are presented as frequency counts (percentage of total) or mean ± SD.

^aP < 0.05, NRS vs RS. RS: HBeAg seroconversion; NRS: No HBeAg seroconversion; HBV: Hepatitis B virus; ALT: Alanine aminotransferase; HBsAg: Hepatitis B surface antigen; HBeAg: Hepatitis B e antigen; anti-HBc: Antibody to hepatitis B core antigen.

Table 2 Factors at baseline influencing hepatitis B e antigen seroconversion in treated patients evaluated using univariate and multivariate analyses n (%)

Parameter	RS	Univariate analysis	P value	Multivariate analysis	P value
Parameter	RS	OR (95%CI)	P value	OR (95%CI)	P value
Female gender	14 (34.1)	1.15 (0.53-2.47)	0.725
Age > 24 yr	26 (40.0)	1.94 (0.96-3.91)	0.065
ALT > 4 × ULN	33 (44.6)	3.39 (1.62-7.12)	0.001	2.44 (1.10-5.42)	0.028
HBV DNA ≤ 7
log₁₀ copies/mL	22 (39.3)	1.71 (0.84-3.46)	0.138
HBsAg ≤ 15000 IU/mL	27 (40.3)	2.03 (1.00-4.09)	0.049
HBeAg ≤ 500 S/CO	26 (47.3)	3.03 (1.48-6.22)	0.003	2.12 (0.97-4.64)	0.060
anti-HBc > 11.4 S/CO	33 (45.8)	3.69 (1.75-7.75)	0.001	3.02 (1.39-6.57)	0.005
Genotype B	26 (30.6)	0.91 (0.50-1.65)	0.749

ALT: Alanine aminotransferase; ULN: Upper limit of normal; HBV: Hepatitis B virus; HBsAg: hepatitis B surface antigen; HBeAg: Hepatitis B e antigen; anti-HBc: Antibody to hepatitis B core antigen; RS: Patients with HBeAg seroconversion.

Table 3 Factors at 12 wk influencing hepatitis B e antigen seroconversion in treated patients evaluated using univariate and multivariate analyses n (%)

Parameter	RS	Univariate analysis	P value	Multivariate analysis	P value
Parameter	RS	OR (95%CI)	P value	OR (95%CI)	P value
ALT > 7 × ULN	8 (61.5)	3.90 (1.20-12.66)	0.024
HBV DNA ≤ 5 log₁₀ copies/mL	31 (53.4)	5.24 (2.48-11.06)	< 0.001
HBsAg ≤ 10000 IU/mL	41 (48.2)	8.70 (3.39-22.34)	< 0.001
HBeAg ≤ 250 S/CO	44 (55.7)	27.24 (7.89-94.09)	< 0.001	10.90 (2.63-45.27)	0.001
anti-HBc > 11.8 S/CO	23 (47.9)	2.88 (1.39-5.96)	0.005	3.72 (1.41-9.84)	0.008
Decline ALT > 3 × ULN	20 (40.0)	1.73 (0.84-3.55)	0.136
Decline HBV DNA > 1.5 log₁₀ copies/mL	34 (48.6)	4.65 (2.18-9.93)	< 0.001
Decline HBsAg > 0.5 log₁₀ IU/mL	29 (55.8)	5.39 (2.55-11.42)	< 0.001
Decline HBeAg > 1 log₁₀ S/CO	34 (66.7)	12.77 (5.60-29.14)	< 0.001	4.53 (1.59-12.91)	0.005
Decline anti-HBc > 0.5 S/CO	13 (40.6)	1.64 (0.53-5.07)	0.393

ALT: Alanine aminotransferase; ULN: Upper limit of normal; HBV: Hepatitis B virus; HBsAg: Hepatitis B surface antigen; HBeAg: Hepatitis B e antigen; anti-HBc: Antibody to hepatitis B core antigen; RS: Patients with HBeAg seroconversion.

Table 4 Factors at 24 wk influencing hepatitis B e antigen seroconversion in treated patients evaluated using univariate and multivariate analyses n (%)

Parameter	RS	Univariate analysis	P value	Multivariate analysis	P value
Parameter	RS	OR (95%CI)	P value	OR (95%CI)	P value
ALT ≤ 1 × ULN	25 (45.5)	2.65 (1.30-5.42)	0.008
HBV DNA ≤ 4 log10 copies/mL	32 (50.8)	4.48 (2.25-10.01)	< 0.001
HBsAg ≤ 2000 IU/mL	33 (52.4)	5.50 (2.58-11.73)	< 0.001
HBeAg ≤ 5 S/CO	41 (65.1)	24.23 (9.11-64.47)	< 0.001	16.82 (5.07-55.79)	< 0.001
anti-HBc > 11.4 S/CO	30 (44.8)	3.01 (1.46-6.18)	0.003	3.01 (1.20-7.56)	0.019
Decline ALT > 2 × ULN	35 (42.2)	3.16 (1.47-6.78)	0.003
Decline HBV DNA > 2 log₁₀ copies/mL	36 (46.8)	4.71 (2.15-10.32)	< 0.001
Decline HBsAg > 1 log₁₀ IU/mL	26 (49.1)	3.35 (1.62-6.91)	0.001
Decline HBeAg > 2 log₁₀ S/CO	30 (66.7)	10.00 (4.45-22.47)	< 0.001	1.85 (0.62-5.49)	0.269
Decline anti-HBc > 0.5 S/CO	19 (47.5)	2.55 (1.20-5.43)	0.015

Citation: Wang CT, Zhang YF, Sun BH, Dai Y, Zhu HL, Xu YH, Lu MJ, Yang DL, Li X, Zhang ZH. Models for predicting hepatitis B e antigen seroconversion in response to interferon-α in chronic hepatitis B patients. World J Gastroenterol 2015; 21(18): 5668-5676
URL: https://www.wjgnet.com/1007-9327/full/v21/i18/5668.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i18.5668