Individual having a parent with early-onset gastric cancer may need screening at younger age

Table 1 Clinicopathologic characteristics of patients with or without a first-degree family history of gastric cancer n (%)

	Total (4282)	With first-degree family history	Without first-degree family history
		n = 924 (21.6%)	n = 3358 (78.4%)	P value
Age at diagnosis, yr (mean ± SD)	58.0 ± 11.8	58.0 ± 10.7	58.1 ± 12.0	0.8971
Male	2886 (67.4)	620 (67.1)	2266 (67.5)	0.8271
Female	1396 (32.6)	304 (32.9)	1092 (32.5)
Tumor diameter (mean ± SD)	4.0 ± 2.7	3.8 ± 2.6	4.2 ± 2.8	0.0041
Lauren’s classification				< 0.0012
Intestinal	2251 (52.6)	544 (58.9)	1707 (50.8)
Diffuse	1642 (38.3)	300 (32.5)	1342 (40.0)
Mixed	389 (9.1)	80 (8.6)	309 (9.2)
H. pylori infection status				0.1742
Current	2851 (66.6)	612 (66.2)	2239 (66.7)
Past	622 (14.5)	114 (12.3)	508 (15.1)
Negative	536 (12.5)	119 (12.9)	417 (12.4)
Not available	273 (6.4)	79 (8.5)	194 (5.8)
GC stage				0.0812
Stage 1	3009 (70.3)	679 (73.5)	2330 (69.4)
Stage 2	568 (13.3)	114 (12.3)	454 (13.5)
Stage 3	476 (11.1)	92 (10.0)	384 (11.4)
Stage 4	229 (5.3)	39 (4.2)	190 (5.7)

¹Independent t-test;

²χ² test. SD: Standard deviation; GC: Gastric cancer; H. pylori: Helicobacter pylori.

Table 2 Age at diagnosis and clincopathologic characteristics of patients with gastric cancer according to affected first-degree family member n (%)

	Father	Mother	Sibling	P value
	n = 349 (37.8%)	n = 229 (24.8%)	n = 319 (34.5%)	Father vs mother	Father vs sibling	Mother vs sibling
Age at diagnosis, yr (mean ± SD)	54.4 ± 10.4	57.2 ± 10.0	62.2 ± 9.8	0.0021	< 0.0011	< 0.0011
Male	252 (72.2)	137 (59.8)	213 (66.8)	0.0022	0.1272	0.0952
Female	97 (27.8)	92 (40.2)	106 (33.2)
Tumor diameter (mean ± SD)	3.9 ± 2.8	3.9 ± 2.4	3.8 ± 2.4	0.9881	0.6611	0.6611
Lauren’s classification				0.7642	0.0032	0.0212
Intestinal	191 (54.7)	132 (57.6)	205 (64.3)
Diffuse	130 (37.3)	81 (35.4)	80 (25.1)
Mixed	28 (8.0)	16 (7.0)	34 (10.7)
H. pylori infection status				0.5302	0.5192	0.8272
Current	241 (69.1)	150 (65.5)	206 (64.6)
Past	43 (12.3)	25 (10.9)	42 (13.2)
Negative	37 (10.6)	32 (14.0)	45 (14.1)
Not available	28 (8.0)	22 (9.6)	26 (8.2)
Gastric cancer stage				0.1932	0.7462	0.1862
Stage 1	254 (72.8)	166 (72.5)	235 (73.7)
Stage 2	41 (11.7)	28 (12.2)	43 (13.5)
Stage 3	35 (10.0)	30 (13.1)	27 (8.5)
Stage 4	19 (5.4)	5 (2.2)	14 (4.4)

¹Independent t-test;

²χ² test. H. pylori: Helicobacter pylori.

Table 3 Age at diagnosis of patient with first-degree family member diagnosed gastric cancer before and after 50 years old

Family member diagnosed before 50 yr old(n = 172)		Family member diagnosed after 50 yr old(n = 752)	P value
Father	47.7 ± 10.3	55.3 ± 10.1	< 0.0011
	(n = 39)	(n = 310)
Mother	48.6 ± 10.4	58.2 ± 9.5	< 0.0011
	(n = 24)	(n = 205)
Sibling	57.4 ± 11.5	64.3 ± 8.1	< 0.0011
	(n = 100)	(n = 219)
Total	54.6 ± 10.5	58.8 ± 10.2	< 0.0011

¹Independent t-test. Data are presented as mean ± SD.

Table 4 Age at diagnosis of patients with a first-degree family member diagnosed with gastric cancer before 50 years of age and patients without a first-degree family history n (%)

Patient’s age at diagnosis, (yr)	Patients with family member diagnosed before 50 yr of age			Patients without a first-degree family history
	Father	Mother	Sibling
	n = 39	n = 24	n = 100	n = 3358
< 40	10 (25.6)	5 (20.8)	7 (7.0)	239 (7.1)
40-49	13 (33.3)	8 (33.3)	19 (19.0)	610 (18.2)
50-59	10 (25.6)	6 (25.0)	31 (31.0)	854 (25.4)
≥ 60	6 (15.4)	5 (20.8)	43 (43.0)	1655 (49.3)
P-value1	< 0.001	0.004	0.573

¹Compared with patients without first-degree family history, χ² test.