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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 21, 2015; 21(15): 4592-4598
Published online Apr 21, 2015. doi: 10.3748/wjg.v21.i15.4592
Published online Apr 21, 2015. doi: 10.3748/wjg.v21.i15.4592
Individual having a parent with early-onset gastric cancer may need screening at younger age
Hee-Won Kwak, Il Ju Choi, Chan Gyoo Kim, Jong Yeul Lee, Soo-Jeong Cho, Bang Wool Eom, Hong Man Yoon, Keun Won Ryu, Young-Woo Kim, Center for Gastric Cancer, National Cancer Center, Goyang 410-769, South Korea
Jungnam Joo, Biometric Research Branch, National Cancer Center, Goyang 410-769, South Korea
Author contributions: Kwak HW collected, analyzed the data, and drafted the manuscript; Choi IJ designed and supervised the study and revised the manuscript; Joo J supervised statistical analysis; Kim CG, Lee JY, Cho SJ, Eom BW, Yoon HM, Ryu KW and Kim YW collected the data and revised the manuscript; all the authors have read and approved the final version to be published.
Supported by National Cancer Center, No.1310280.
Ethics approval: This study has been approved by IRB of National Cancer Center (IRB number: NCCNCS13820).
Informed consent: National cancer center IRB exempted obtaining informed consent from all the individuals due to restrospective study design.
Conflict-of-interest: The authors do not have any financial disclosures, conflicts of interest, and/or acknowledgements.
Data sharing: Dataset are available from the corresponding author at cij1224@ncc.re.kr.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Il Ju Choi, MD, PhD, Center for Gastric Cancer, National Cancer Center, 323 Ilsan-ro, Ilsan dong-gu, Goyang, Gyeonggi 410-769, South Korea. cij1224@ncc.re.kr
Telephone: +82-31-9202282 Fax: +82-31-9202799
Received: November 9, 2014
Peer-review started: November 10, 2014
First decision: November 26, 2014
Revised: January 7, 2014
Accepted: January 30, 2015
Article in press: January 30, 2015
Published online: April 21, 2015
Peer-review started: November 10, 2014
First decision: November 26, 2014
Revised: January 7, 2014
Accepted: January 30, 2015
Article in press: January 30, 2015
Published online: April 21, 2015
Core Tip
Core tip: A family history of cancer is associated with earlier age of onset of several cancers, but not clear in gastric cancer (GC). We found that individuals with a paternal history of GC tended to diagnosis at younger age than those patients without family history, also individuals with a parent diagnosed before 50 years of age developed GC about 10 years earlier than those patients without family history. The finding that patients with a parental history of GC, especially those who had parents with early-onset GC, diagnosed at younger age supports the need for early screening in these individuals.