Arpin contributes to bacterial translocation and development of severe acute pancreatitis

Table 1 Characteristics of subjects and healthy controls

	SAP	HC	P value
Gender (M/F)	31/19	13/7	0.0821
Age (yr)	55.0 ± 12.3	55.0 ± 5.2	0.7532
Ranson score	4.3 ± 1.8	2.0 ± 1.8	0.0322
APACHE-II score	15.0 ± 5.8	4.5 ± 2.1	0.0292

¹Pearson’s two-test;

²Two-sample t-test. HC: Healthy control; SAP: Severe acute pancreatitis; APACHE: Acute Physiology and Chronic Health Evaluation.

Table 2 Arpin and tight junction proteins expression

	HC (n = 20)	SAP
		Total (n = 50)	BT(-) (n = 19)	BT(+) (n = 31)	P value1
Arpin	0.28 ± 0.16	0.38 ± 0.19	0.31 ± 0.24	0.61 ± 0.28	0.003
Zonula occludens-1	0.89 ± 0.46	0.48 ± 0.23	0.58 ± 0.17	0.42 ± 0.26	0.038
Claudin-2	0.73 ± 0.32	0.49 ± 0.19	0.32 ± 0.21	0.64 ± 0.27	0.021
Occludin	0.85 ± 0.36	0.68 ± 0.21	0.73 ± 0.32	0.61 ± 0.28	0.010

¹SAP-BT (-) vs SAP-BT (+), one-way ANOVA. Data are expressed as mean ± SD. HC: Healthy control; SAP: Severe acute pancreatitis.