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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 14, 2015; 21(14): 4293-4301
Published online Apr 14, 2015. doi: 10.3748/wjg.v21.i14.4293
Published online Apr 14, 2015. doi: 10.3748/wjg.v21.i14.4293
Arpin contributes to bacterial translocation and development of severe acute pancreatitis
Wen-Sheng Deng, Jiang Wang, Hong-Mei Zheng, Dian-Liang Zhang, Center of Colon and Rectum, Qingdao Municipal Hospital, Qingdao University, Qingdao 266011, Shandong Province, China
Jian Zhang, Su Wang, Department of General Surgery, The Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong Province, China.
Hui Ju, Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong Province, China
Author contributions: Zhang DL designed the study; Deng WS, Wang J and Wang S performed the research; Zhang J contributed new reagents and analytical tools; Deng WS analyzed the data; Deng WS wrote the paper; Ju H performed the endoscopy.
Supported by Natural Science Foundation of China, No. 81270448 and No. 81470890.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dian-Liang Zhang, MD, PhD, Center of Colon and Rectum, Qingdao Municipal Hospital, Qingdao University, No. 16 Jiangsu Road, Qingdao 266011, Shandong Province, China. phdzdl@yahoo.com
Telephone: +86-532-82852057 Fax: +86-532-82852058
Received: November 10, 2014
Peer-review started: November 12, 2014
First decision: December 11, 2014
Revised: January 11, 2015
Accepted: February 5, 2015
Article in press: February 5, 2015
Published online: April 14, 2015
Peer-review started: November 12, 2014
First decision: December 11, 2014
Revised: January 11, 2015
Accepted: February 5, 2015
Article in press: February 5, 2015
Published online: April 14, 2015
Core Tip
Core tip: Tight junctions (TJs) are the structural basis for the intestinal epithelial barrier. Increased intestinal permeability caused by variations in TJ proteins may result in bacterial translocation (BT) and there is evidence that BT may contribute to infection and sepsis. However, the detailed mechanisms for BT remain unknown. Recent work has identified an Arp2/3 interacting protein called Arpin, which was shown to restrict the rate of actin polymerization and control cell migration. Our research shows that Arpin protein affects the expression of TJ proteins and may have an impact on BT.