Evaluation of the 7th edition of the TNM classification in patients with resected esophageal squamous cell carcinoma

Table 1 Patient demographics and 5-year survival n (%)

Characteristic	Value	5-yr survival
Gender Male Female	793 (76.8) 240 (23.2)	43.1%47.2%
Age, yr Median (range) ≤ 60 > 60	63 (27-81) 688 (66.6)345 (33.4)	44.6%42.9%
Cigarette smoking Yes No	544 (52.7) 489 (47.3)	42.7%45.5%
Alcohol consumption Yes No	272 (26.3)761 (73.7)	43.6%44.1%
pT 1 2 3 4	198 (19.2) 238 (23.0)575 (55.7)22(2.1)	74.6%47.3%32.8%15.6%
pN 0 1 2 3	544 (52.7)269 (26.0)152 (14.7)68 (6.6)	52.1%46.7%25.3%11.8%
pM 0 1	998 (96.6)35 (3.4)	45.2%9.1%
Histologic grade Well differentiated (G1) Moderately differentiated (G2) Poorly differentiated (G3)	288 (27.9)489 (47.3)256 (24.8)	43.3%45.8%41.4%
Cancer location Upper thoracic Middle thoracic Lower thoracic + GEJ	206 (19.3) 603 (58.6)224 (22.2)	47.6%44.2%40.3%
Type of surgical approach Left thoracic Right thoracic	126 (12.2)907 (87.8)	40.4%44.5%
Length of tumorMean (range) ≤ Mean > Mean	3.4 cm (0.4-15.0 cm)689 (66.7)344 (33.3)	44.1%43.9%
Stage IA IB IIA IIB IIIA IIIB IIIC IV	30 (2.9)144 (13.9)122 (11.8)324 (31.4)224 (21.7)106 (10.3)54 (5.2)29 (2.8)	84.9%70.9%56.2%43.3%37.9%23.3%12.9%3.4%
(neo)adjuvant therapy No Yes	760 (73.6)273 (26.4)	49.8%30.3%

GEJ: Gastroesophageal junction.

Table 2 Univariate and multivariate analyses of factors

	Univariate			Multivariate
	HR	95%CI	P-value	HR	95%CI	P-value
Gender Male Female	1.0000.829	0.690-0.996	0.046	1.0001.333	1.091-1.629	0.005
Age, yr ≤ 60 > 60	1.0001.183	1.009-1.390	0.039	1.0000.999	0.840-1.190	0.995
Cigarette smoking No Yes	1.0001.190	1.019-1.388	0.027	1.0000.949	0.805-1.119	0.537
Alcohol consumption No Yes	1.0001.070	0.903-1.268	0.431
(neo) adjuvant therapy No Yes	1.0001.634	1.386-1.927	< 0.001	1.0001.330	1.102-1.606	0.003
pT 1 2 3 4	1.0002.4874.1865.154	1.856-3.3313.219-5.4443.015-8.812	< 0.001< 0.001< 0.001	1.0001.9822.3031.150	1.254-3.1321.437-3.6930.518-2.549	0.0030.0010.732
pN 0 1 2 3	1.0001.2941.9393.500	1.073-1.5601.567-2.3992.650-4.624	0.007< 0.001< 0.001	1.0000.3610.2900.122	0.242-0.5380.145-0.5800.047-0.314	< 0.001< 0.001< 0.001
pM 0 1	1.0003.392	2.359-4.875	< 0.001	1.0000.789	0.231-2.689	0.704
Histologic grade G1 G2 G3	1.0001.0541.227	0.875-1.2710.995-1.513	0.5780.056	1.0000.9170.874	0.724-1.1610.681-1.123	0.4720.292
Cancer location Upper thoracic Middle thoracic Lower thoracic + GEJ	1.0001.2011.326	0.977-1.4761.043-1.685	1.2011.326	1.0000.8081.027	0.634-1.0310.758-1.392	0.0860.862
Type of surgical approach Right thoracic Left thoracic	1.0001.149	0.912-1.448	0.238
Length of tumor ≤ Mean > Mean	1.0001.075	0.916-1.262	0.374

HR: Hazard ratio; CI: Confidence interval.

Table 3 Univariate and multivariate analyses of the 7^th edition of the TNM classification

	Univariate			Multivariate
	HR	95%CI	P-value	HR	95%CI	P-value
Stage
IA	1.000			1.000
IB	2.919	1.059-8.048	0.038	3.013	1.065-8.530	0.038
IIA	4.771	1.737-13.103	0.002	2.368	0.779-7.198	0.129
IIB	7.251	2.695-19.508	< 0.001	6.472	2.083-20.108	0.001
IIIA	9.062	3.359-24.450	< 0.001	15.152	4.282-53.616	< 0.001
IIIB	12.314	4.514-33.591	< 0.001	23.933	4.960-88.354	< 0.001
IIIC	18.288	6.583-50.804	< 0.001	89.566	18.855-425.471	< 0.001
IV	33.720	11.799-96.369	< 0.001	147.116	21.759-994.681	< 0.001