Prognosis of ulcerative colitis differs between patients with complete and partial mucosal healing, which can be predicted from the platelet count

Table 1 Baseline characteristics of analyzed patients n (%)

Patients	Value
Total	183
Gender
Male	93 (51)
Female	90 (49)
Extent of disease
Pancolitis	112 (61)
Left-side colitis	40 (22)
Proctitis	31 (17)
Median (IQR) age at onset	32 (22-45)
Median (range) duration of disease, mo	108 (54-202)
Median (range) age of undergoing colonoscopy	44 (33-59)
Concomitant medications
Aminosalicylate	163 (89)
Corticosteroids	23 (13)
Mercaptopurine/azathioprine	70 (38)
Tacrolimus	5 (3)
Biologics	7 (4)
Colonoscopy findings (maximum index in the colorectum)
MES 0	80 (44)
MES 1	89 (48)
MES 2	14 (8)

MES: Mayo endoscopic subscore; IQR: Interquartile range.

Table 2 Characteristics of patients with Mayo endoscopic subscore 0 vs 1 or 2 n (%)

Characteristics	MES 0 (n = 80)	MES 1, 2 (n = 103)	P value
Gender
Male	45 (56)	48 (47)	0.2
Female	35 (44)	55 (53)
Median age, yr (IQR)	49 (37-62)	40 (32-54)	0.009
Median duration of disease, mo (IQR)	98 (52-213)	122 (57-202)	0.73
Median age at onset, yr (IQR)	36 (25-50)	29 (19-40)	0.009
Extent of disease
Pancolitis	42 (53)	70 (68)	0.1
Left-side colitis	21 (26)	19 (18)
Proctitis	17 (21)	14 (14)
Concomitant medications
Aminosalicylate	72 (90)	91 (88)	0.72
Corticosteroids	12 (15)	11 (11)	0.38
Mercaptopurine/azathioprine	28 (35)	42 (41)	0.43
Tacrolimus	3 (4)	2 (2)	0.46
Biologics	2 (3)	5 (5)	0.41
Blood markers, median (IQR)
CRP (mg/L)	0.4 (0.2-1.0)	0.5 (0.2-1.2)	0.3
WBC (/μL)	5160 (4130-5990)	5660 (4830-6800)	0.017
Hb (g/dL)	13.6 (12.4-15.0)	13.5 (12.4-14.7)	0.75
PLT (× 104/μL)	24.7 (21.7-27.6)	29.1 (25.6-33.4)	< 0.0001
Alb (g/dL)	4.5 (4.2-4.8)	4.4 (4.1-4.7)	0.17

MES: Mayo endoscopic subscore; IQR: Interquartile range; CRP: C-reactive protein; WBC: White blood cell; Hb: Hemoglobin; PLT: Platelet count; Alb: Albumin.

Table 3 Univariate and multivariate analysis for factors predictive of Mayo endoscopic subscore 0

	OR	Univariate analysis95%CI	P value	OR	Multivariate analysis95%CI	P value
Age > 48 yr	2.59	1.42-4.78	0.002	1.88	0.79-4.52	0.15
Age at onset > 32 yr	2.39	1.32-4.38	0.004	1.46	0.61-3.46	0.39
WBC < 5900/μL	2.65	1.43-5.05	0.002	2.37	1.19-4.81	0.014
PLT < 26 × 104/μL	4.74	2.55-9.01	< 0.0001	4.10	2.15-7.99	< 0.0001

WBC: White blood cell; PLT: Platelet count.

Table 4 Predictive values of white blood cell and platelet count for Mayo endoscopic subscore 0 in patients with sustained clinical remission

	WBC < 5900/μLonly	PLT < 26 × 104/μLonly	Either WBC < 5900/μL or PLT < 26 × 104/μL	Both WBC < 5900/μL and PLT < 26 × 104/μL
Sensitivity (95%CI)	0.74 (0.66-0.81)	0.65 (0.57-0.72)	0.91 (0.85-0.95)	0.48 (0.40-0.54)
Specificity (95%CI)	0.49 (0.42-0.54)	0.72 (0.66-0.77)	0.39 (0.34-0.42)	0.82 (0.76-0.87)

WBC: White blood cell; PLT: Platelet count; MES: Mayo endoscopic subscore.

Table 5 Change in blood marker values in patients with or without maintenance of complete mucosal healing n (%)

Variables	Maintenance of MES 0 (n = 26)	Shift to MES 1 (n = 21)	P value
Extent of disease
Pancolitis	13 (50)	13 (62)
Left-side colitis	10 (38)	3 (14)
Proctitis	3 (12)	5 (24)	0.15
Median (IQR) age at onset	36 (27-49)	28 (23-43)	0.2
Median (range) duration of disease, mo	132 (55-220)	152 (64-244)	0.65
Change in values of parameters
median (IQR)
ΔCRP (mg/L)	0.1 (-0.1-0.4)	0 (0.2-0.4)	0.95
ΔWBC (/μL)	-200 (-1680-780)	280 (-330-1030)	0.16
ΔHb (g/dL)	0.1 (-0.3-0.8)	0.4 (-0.1-0.8)	0.25
ΔPLT (× 104/μL)	-0.6 (-2.4-1.5)	3.8 (1.5-8.0)	< 0.0001
ΔAlb (g/dL)	0.1 (-0.2-0.3)	0 (-0.1-0.2)	0.82

MES: Mayo endoscopic subscore; IQR: Interquartile range, CRP: C-reactive protein; WBC: White blood cell; Hb: Hemoglobin; PLT: Platelet count; Alb: Albumin.