Copyright
©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 28, 2014; 20(48): 18367-18374
Published online Dec 28, 2014. doi: 10.3748/wjg.v20.i48.18367
Published online Dec 28, 2014. doi: 10.3748/wjg.v20.i48.18367
Prognosis of ulcerative colitis differs between patients with complete and partial mucosal healing, which can be predicted from the platelet count
Asuka Nakarai, Sakiko Hiraoka, Toshihiro Inokuchi, Daisuke Takei, Yuki Moritou, Mitsuhiro Akita, Sakuma Takahashi, Kazuhide Yamamoto, Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan
Jun Kato, Second Department of Internal Medicine, Wakayama Medical University, Wakayama 641-0012, Japan
Keisuke Hori, Keita Harada, Hiroyuki Okada, Department of Endoscopy, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan
Author contributions: Nakarai A performed the research; Kato J, Hiraoka S, Inokuchi T, Takei D, Moritou Y, Akita M, Takahashi S, Hori K, and Harada K designed the research study; Nakarai A wrote the paper; Okada H and Yamamoto K contributed to the design of the study.
Correspondence to: Sakiko Hiraoka, MD, Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan. sakikoh@cc.okayama-u.ac.jp
Telephone: +81-86-235-7219 Fax: +81-86-225-5991
Received: April 8, 2014
Revised: June 11, 2014
Accepted: July 16, 2014
Published online: December 28, 2014
Revised: June 11, 2014
Accepted: July 16, 2014
Published online: December 28, 2014
Core Tip
Core tip: Mucosal healing has been recognized as the treatment goal of ulcerative colitis (UC). Although many previous reports defined mucosal healing as Mayo endoscopic subscore (MES) of 0 or 1, the difference in prognosis between patients with MES 0 and those with MES 1 has scarcely been evaluated. This paper indicated that the relapse rate differed greatly between patients with MES 0 and MES 1, and that the treatment goal of UC should be MES 0. We also demonstrated that a shift from MES 0 to MES 1 in clinically stable UC patients can be predicted by monitoring platelet count.