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©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Dec 14, 2014; 20(46): 17456-17462
Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17456
Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17456
Table 1 Selected characteristics of cases and controls n (%)
Casesn = 360 | Controlsn = 400 | |
Age, mean ± SD | 67.8 ± 8.8 | 64.8 ± 9.5 |
Sex | ||
Male | 215 (59.7) | 226 (56.5) |
Female | 145 (40.3) | 174 (43.5) |
BMI, mean ± SD | 22.9 ± 3.3 | 22.8 ± 3.2 |
History of diabetes | ||
Yes | 87 (24.1) | 35 (8.7) |
No | 269 (74.7) | 362 (90.5) |
Cigarette smoking | ||
Ever | 215 (59.7) | 198 (49.5) |
Never | 145 (40.2) | 202 (50.5) |
Age upon starting smoking (mean ± SD) | 21.8 ± 4.8 | 20.5 ± 4.5 |
Number of cigarettes smoked per day (mean ± SD) | 20.3 ± 9.0 | 16.2 ± 9.2 |
Table 2 Single-nucleotide polymorphisms profile
Rs number | Gene | Chromosome location | Risk allele1 | Alternative allele |
rs1801282 | PPARG2 | 3p25 | C | G |
rs1501299 | ADIPOQ | 3q27 | C | A |
rs4994 | ADRB3 | 8p12 | C | T |
rs2237895 | KCNQ1 | 11p15 | C | A |
rs5219 | KCNJ11 | 11q23 | T | C |
rs7903146 | TCF7L2 | 10q25 | T | C |
rs2206734 | CDKAL1 | 6p22 | A | G |
Table 3 Associations between diabetes-associated single-nucleotide polymorphisms and pancreatic cancer risk
Gene | SNP | Genotype | Case, n | Control, n | Age- and sex-adjusted OR (95%CI) | 1Multivariable-adjusted OR (95%CI) |
PPARG2 | rs1801282 | GG + CG | 26 | 27 | 1.00 | 1.00 |
CC | 334 | 373 | 0.83 (0.47-1.46) | 0.77 (0.43-1.38) | ||
ADIPOQ | rs1501299 | AA | 19 | 38 | 1.00 | 1.00 |
AC | 155 | 167 | 1.79 (0.98-3.25) | 1.71 (0.93-3.15) | ||
CC | 186 | 195 | 1.86 (1.03-3.38) | 1.85 (1.01-3.39) | ||
CDKAL1 | rs2206734 | GG | 114 | 138 | 1.00 | 1.00 |
AG | 184 | 195 | 1.15 (0.83-1.59) | 1.18 (0.85-1.64) | ||
AA | 62 | 67 | 1.16 (0.75-1.79) | 1.21 (0.78-1.89) | ||
ADRB3 | rs4994 | TT | 228 | 255 | 1.00 | 1.00 |
CT | 114 | 131 | 0.92 (0.67-1.25) | 0.88 (0.64-1.21) | ||
CC | 18 | 14 | 1.37 (0.66-2.83) | 1.36 (0.65-2.87) | ||
KCNQ1 | rs2237895 | AA | 153 | 156 | 1.00 | 1.00 |
AC | 175 | 193 | 0.95 (0.70-1.29) | 0.92 (0.67-1.26) | ||
CC | 32 | 51 | 0.62 (0.37-1.02) | 0.62 (0.37-1.04) | ||
KCNJ11 | rs5219 | CC | 150 | 159 | 1.00 | 1.00 |
CT | 157 | 192 | 0.87(0.64-1.18) | 0.90 (0.66-1.24) | ||
TT | 53 | 49 | 1.14 (0.72-1.79) | 1.19 (0.75-1.90) | ||
TCF7L2 | rs7903146 | CC | 354 | 394 | 1.00 | 1.00 |
CT + TT | 6 | 6 | 1.20 (0.38-3.83) | 1.16 (0.36-3.72) |
- Citation: Kuruma S, Egawa N, Kurata M, Honda G, Kamisawa T, Ueda J, Ishii H, Ueno M, Nakao H, Mori M, Matsuo K, Hosono S, Ohkawa S, Wakai K, Nakamura K, Tamakoshi A, Nojima M, Takahashi M, Shimada K, Nishiyama T, Kikuchi S, Lin Y. Case-control study of diabetes-related genetic variants and pancreatic cancer risk in Japan. World J Gastroenterol 2014; 20(46): 17456-17462
- URL: https://www.wjgnet.com/1007-9327/full/v20/i46/17456.htm
- DOI: https://dx.doi.org/10.3748/wjg.v20.i46.17456