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World J Gastroenterol. Dec 14, 2014; 20(46): 17456-17462
Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17456
Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17456
Case-control study of diabetes-related genetic variants and pancreatic cancer risk in Japan
Sawako Kuruma, Terumi Kamisawa, Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, Tokyo 113-8677, Japan
Naoto Egawa, Tokyo Metropolitan Ohtsuka Hospital, Tokyo 170-8476, Japan
Masanao Kurata, Goro Honda, Department of Surgery, Tokyo Metropolitan Komagome Hospital, Tokyo 113-8677, Japan
Junko Ueda, Takeshi Nishiyama, Shogo Kikuchi, Yingsong Lin, Department of Public Health, Aichi Medical University School of Medicine, Nagakute 480-1195, Japan
Hiroshi Ishii, Hepatobiliary and Pancreatic Section, Gastroenterological Division, Cancer Institute Hospital, Tokyo 135-8550, Japan
Makoto Ueno, Shinichi Ohkawa, Hepatobiliary and Pancreatic Medical Oncology Division, Kanagawa Cancer Center Hospital, Kanagawa 241-8515, Japan
Haruhisa Nakao, Division of Gastroenterology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute 480-1195, Japan
Mitsuru Mori, Masanori Nojima, Department of Public Health, Sapporo Medical University School of Medicine, Sapporo 060-8556, Japan
Keitaro Matsuo, Department of Preventive Medicine, Kyushu University Faculty of Medical Science, Fukuoka 812-8582, Japan
Satoyo Hosono, Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan
Kenji Wakai, Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan
Kozue Nakamura, Department of Food and Nutrition, Gifu City Women’s College, Gifu 501-2592, Japan
Akiko Tamakoshi, Department of Public Health, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan
Mami Takahashi, Central Animal Division, National Cancer Center Research Institute, Tokyo 104-0045, Japan
Kazuaki Shimada, Department of Hepatobiliary and Pancreatic Surgery, National Cancer Center Hospital, Tokyo 104-0045, Japan
Author contributions: Kikuchi S supervised the study; Kikuchi S, Lin Y, Kuruma S, Egawa N, Wakai K, Nakamura K, Tamakoshi A, Takahashi M and Shimada K designed the research; Kuruma S, Egawa N, Lin Y and Nishiyama T drafted the manuscript and conducted the statistical analysis; Ueda J, Hosono S and Matsuo K performed genotyping and SNP data analysis; Kuruma S, Egawa N, Kurata M, Honda G, Kamisawa T, Ishii H, Ueno M, Nakao H, Mori M, Ohkawa S and Nojima M participated in data collection; all authors read and approved the final manuscript.
Supported by Grants-in-Aid for Cancer Research from the Ministry of Health, Labour and Welfare, Japan
Correspondence to: Dr. Yingsong Lin, Department of Public Health, Aichi Medical University School of Medicine, 1-1 Yazakokarimata, Nagakute, 480-1195, Japan. linys@aichi-med-u.ac.jp
Telephone: +81-561-623311 Fax: +81-561-625270
Received: March 4, 2014
Revised: April 18, 2014
Accepted: July 24, 2014
Published online: December 14, 2014
Processing time: 289 Days and 6.4 Hours
Revised: April 18, 2014
Accepted: July 24, 2014
Published online: December 14, 2014
Processing time: 289 Days and 6.4 Hours
Core Tip
Core tip: Although it is likely that a common genetic background predisposes individuals to developing both diabetes and pancreatic cancer, very few molecular epidemiologic studies have addressed this issue. We therefore genotyped 7 diabetes-related genetic variants and found that rs1501299 in the ADIPOQ gene may be associated with pancreatic cancer risk. The role of adiponectin variants needs further study.