Evidence-based assessment of proton-pump inhibitors in Helicobacter pylori eradication: A systematic review

Table 1 First-line regimens for Helicobacter pylori eradication[88]

Regimen	Standard dose PPI bid (esomeprazole is qid), clarithromycin 500 mg bid, amoxicillin 1000 mg bid for 10–14 d	Standard dose PPI bid, clarithromycin 500 mg bid metronidazole 500 mg bid for 10–14 d	Bismuth subsalicylate 525 mg po qid metronidazole 250 mg po qid, tetracycline 500 mg po qid, ranitidine 150 mg po bid or standard dose PPI qid to bid for 10–14 d	PPI + amoxicillin 1 g bid 5 d followed by PPI, clarithromycin 500 mg, tinidazole 500 mg bid for 5 d
Note	Consider in nonpenicillin allergic patients who have not previously received a macrolide	Consider in penicillin allergic patients who have not previously received a macrolide or are unable to tolerate bismuth quadruple therapy	Consider in penicillin allergic patients	Requires validation in North America

PPI: Proton-pump inhibitors.