Polymorphism of heat shock protein 70-2 and enterocutaneous fistula in Chinese population

Table 1 Clinical characteristics and the heat shock protein 70-2 single nucleotide polymorphism of cases and controls

		Case	Control	P value
		(n = 131)	(n = 140)	OR (95%CI)
Sex (M/F)		94/37	95/45	0.510
Age (yr, mean ± SD)		46.5 ± 15.9	44.0 ± 8.6	0.108
Genotype	AA	47	39	0.074
	AB	65	66
	BB	19	35
Allele	A	159	144	0.038
	B	103	136	1.425 (1.019-1.994)

Table 2 Heat shock protein 70-2 genotype and allele frequencies vs daily output of patients

		Low (n = 41)	Moderate (n = 46)	High (n = 44)
Genotype	AA	12	15	20
	AB	20	27	18
	BB	9	4	6
P		0.0001	0.0002	0.00333
Allele	A	44	57	58
	B	38	35	30
P		0.285	0.642	0.119
OR		0.711	0.842	0.599
95%CI		0.388-1.3011	0.458-1.5492	0.323-1.1123

¹Low output vs moderate output;

²Moderate output vs high output;

³Low output vs high output. Low-output, < 200 mL of effluent daily; moderate, between 200 and 500 mL of effluent daily; high output, > 500 mL of effluent daily.

Table 3 Heat shock protein 70-2 genotype and allele frequencies vs etiology of fistulas

		Iatrogenic injury	Trauma	Malignancy	Infection	P
		(n = 54)	(n = 42)	(n = 34)	(n = 1)	value
Genotype	AA	17	16	14	0	0.257
	AB	29	19	17	0
	BB	8	7	3	1
Allele	A	63	51	45	0	0.241
	B	45	33	23	2

Table 4 Heat shock protein 70-2 genotype and allele frequencies vs fistula location

		Stomach	Duodenum	Small bowel	Colon/rectum	Internal	Complex	P
		(n = 5)	(n = 21)	(n = 55)	(n = 16)	(n = 4)	(n = 30)	value
Genotype	AA	1	5	21	6	0	14	0.410
	AB	3	11	27	9	2	13
	BB	1	5	7	1	2	3
Allele	A	5	21	69	21	2	41	0.119
	B	5	21	41	11	6	19

Table 5 Heat shock protein 70-2 genotype and allele frequencies vs patient survival

		Survived	Deceased	P value
		(n = 113)	(n = 7)	OR (95%CI)
Genotype	AA	40	4	0.484
	AB	56	2
	BB	17	1
Allele	A	136	10	0.403
	B	90	4	0.604 (0.184-1.986)

Table 6 Heat shock protein 70-2 genotype and allele frequencies vs surgical and nonsurgical treatment

		Surgery	No surgery	P value
		(n = 61)	(n = 52)	OR (95%CI)
Genotype	AA	24	16	0.601
	AB	29	27
	BB	8	9
Allele	A	73	59	0.437
	B	45	45	1.237 (0.723-2.117)

Table 7 Heat shock protein 70-2 genotype and allele frequencies vs recurrent and nonrecurrent fistulas after surgery

		Recurrence	No recurrence	P value
		(n = 51)	(n = 10)	OR (95%CI)
Genotype	AA	20	4	0.949
	AB	24	5
	BB	7	1
Allele	A	64	13	0.848
	B	38	7	0.907 (0.333-2.472)

Table 8 Multivariate analysis using heat shock protein 70-2 frequency as a dependent variable

	P value
Sex	0.073
Age	0.910
Daily output	0.259
Fistula etiology	0.299
Fistula location	0.271
Treatment	0.729

The median age of the patients was 45 years old and used as a cut-off point.