Chen J, Ren JA, Han G, Gu GS, Wang GF, Wu XW, Zhou B, Hu D, Wu Y, Zhao YZ, Li JS. Polymorphism of heat shock protein 70-2 and enterocutaneous fistula in Chinese population. World J Gastroenterol 2014; 20(35): 12559-12565 [PMID: 25253958 DOI: 10.3748/wjg.v20.i35.12559]
Corresponding Author of This Article
Jian-An Ren, MD, FACS, Department of Surgery, the Research Institute of General Surgery, Jinling Hospital, Zhongshan East Road 305, Nanjing 210002, Jiangsu Province, China. jiananr@gmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Evidence-Based Medicine
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Sep 21, 2014; 20(35): 12559-12565 Published online Sep 21, 2014. doi: 10.3748/wjg.v20.i35.12559
Polymorphism of heat shock protein 70-2 and enterocutaneous fistula in Chinese population
Jun Chen, Jian-An Ren, Gang Han, Guo-Sheng Gu, Ge-Fei Wang, Xiu-Wen Wu, Bo Zhou, Dong Hu, Yin Wu, Yun-Zhao Zhao, Jie-Shou Li
Jun Chen, Jian-An Ren, Guo-Sheng Gu, Ge-Fei Wang, Xiu-Wen Wu, Yun-Zhao Zhao, Jie-Shou Li, Department of Surgery, the Research Institute of General Surgery, Jinling Hospital, Nanjing 210002, Jiangsu Province, China
Gang Han, General Surgery Center of the Second Hospital of Jilin University, Changchun 130041, Jilin Province, China
Bo Zhou, Dong Hu, Yin Wu, Department of Surgery, The Research Institute of General Surgery, Jinling Hospital, Nanjing 210002, Jiangsu Province, China
Bo Zhou, Dong Hu, Yin Wu, Medical School of Nanjing University, Nanjing 210000, Jiangsu Province, China
Author contributions: Chen J, Ren JA, Zhao YZ and Li JS designed the research; Chen J performed the research; Han G, Gu GS and Wang GF contributed new reagents and analytic tools; Chen J, Wu XW, Zhou B, Hu D and Wu Y analyzed the data; Chen J wrote the paper.
Supported by Postdoctoral Science Foundation of Jiangsu Province, China No. 0902059C and the National Natural Science Foundation of China No. 81270478
Correspondence to: Jian-An Ren, MD, FACS, Department of Surgery, the Research Institute of General Surgery, Jinling Hospital, Zhongshan East Road 305, Nanjing 210002, Jiangsu Province, China. jiananr@gmail.com
Telephone: +86-25-80860108 Fax: +86-25-80860376
Received: January 20, 2014 Revised: April 8, 2014 Accepted: June 20, 2014 Published online: September 21, 2014
Core Tip
Core tip: Postoperative enterocutaneous fistulas are one of the most devastating abdominal complications after surgery. Currently, enterocutaneous/enteroatmospheric fistulas may be caused by trauma or surgery as a result of traumatic or iatrogenic bowel injury, infection, or anastomotic leakage. However, genetic or epigenetic factors may increase the risk for individual patients to develop enterocutaneous/enteroatmospheric fistulas. We found the frequency of the HSP70-2 PstI polymorphism did not differ between patients and controls; however, the A allele was more predominant in patients with enterocutaneous fistulas than in controls. To our knowledge, this study was the first study about the enterocutaneous fistula and single nucleotide polymorphism.
