Heartburn and regurgitation have different impacts on life quality of patients with gastroesophageal reflux disease

Table 1 Severity distribution of patients in the heartburn and regurgitation group n (%)

Groups	Severity			Total
	Mild	Moderate	Severe
Heartburn group	4 (3.7)	85 (78.7)	19 (17.6)	108
Regurgitation group	6 (4.8)	102 (82.3)	16 (12.9)	124

Table 2 Basic characteristic of the of patients in the heartburn and regurgitation group

Characteristics		Heartburn group (n = 108, 46.6%)		Regurgitation group (n = 124, 53.4%)		P value
		n (%)	mean ± SD	n (%)	mean ± SD
Mean age (yr)			48.72 ± 13.97		44.92 ± 15.30	0.1301
Gender	M	62 (57.4)		48 (38.7)		0.0442
	F	46 (42.6)		76 (61.3)
Weight (kg)			62.30 ± 13.56		63.33 ± 11.85	0.8341
BMI (kg/m2)			22.97 ± 3.87		23.38 ± 3.42	0.8251
H. pylori		28 (25.9)		22 (17.7)		0.2852
Hiatal hernia		30 (27.8)		34 (27.4)		0.9662
ECJ ulcer		8 (7.4)		12 (9.7)		0.6642
Endoscopic finding	NERE	54 (50.0)		56 (45.2)		0.8362
	EE	54 (50.0)		68 (54.8)
Life style	Coffee	70 (64.8)		76 (61.3)		0.6952
	Alcohol	44 (40.7)		48 (38.7)		0.8232
	Tea	84 (77.8)		104 (83.9)		0.4042
	Smoke	20 (18.5)		16 (12.9)		0.4052

¹t test;

²Pearson’s χ² test. BMI: Body mass index; ECJ: Esophagocardiac junction; EE: Erosive esophagitis; F: Female; M: Male; NERD: Non-erosive reflux disease; H. pylori: Helicobacter pylori.

Table 3 Basic characteristic of the of non-erosive reflux disease and erosive esophagitis patients in the heartburn and regurgitation group

Characteristics		Heartburn group				P value	Regurgitation group				P value
		NERD (n = 54, 50%)		EE (n = 54, 50%)			NERD (n = 56, 45.2%)		EE (n = 68, 54.8%)
		n (%)	mean ± SD	n (%)	mean ± SD		n (%)	mean ± SD	n (%)	mean ± SD
Mean age (yr)			46.89 ± 14.75		50.56 ± 13.15	0.3401		39.64 ± 10.23		48.21 ± 19.77	0.0431
Gender	M	22 (40.7)		40 (74.1)		0.0132	16 (28.6)		32 (47.1)		0.1372
	F	32 (59.3)		14 (25.9)			40 (71.4)		36 (52.9)
Weight (kg)			56.59 ± 10.07		68.00 ± 14.34	0.0011		60.28 ± 8.71		64.85 ± 13.67	0.1311
BMI (kg/m2)			21.68 ± 3.43		24.24 ± 3.92	0.0141		22.59 ± 2.90		23.52 ± 3.65	0.2931
H. pylori		14 (25.9)		14 (25.9)		1.0002	8 (14.3)		14 (20.6)		0.5182
Hiatal hernia		8 (14.8)		22 (40.7)		0.0332	16 (28.6)		18 (26.5)		0.8542
ECJ ulcer		0		8 (14.8)		0.0503	0		12 (17.6)		0.0283

¹t test;

²Pearson’s χ² test;

³Fisher exact test. BMI: Body mass index; ECJ: Esophagocardiac junction; EE: Erosive esophagitis; F: Female; M: Male; NERD: Non-erosive reflux disease; H. pylori: Helicobacter pylori.