Decreased expression of miR-133a correlates with poor prognosis in colorectal cancer patients

Table 1 Demographic characteristics of patients with colorectal cancer

Characteristic	Number of cases (n = 175)	miR-133a expressionmedian (IQR)	P value
Sex			0.727
Male	96	127.40 (34.93-535.51)
Female	73	135.30 (31.90-435.10)
Age (yr)			0.800
≤ Median	85	173.72 (39.43-603.81)
> Median	84	109.90 (27.18-311.64)
Tumor location			0.484
Colon	79	135.30 (27.31-468.70)
Rectum	90	132.35 (43.73-525.97)
Differentiation			0.004
Well	18	560.88 (98.18-1027.33)
Moderate	130	134.45 (35.88-434.56)
Poor	21	35.33 (26.05-145.77)
Size			0.527
≤ 5 cm	101	129.59 (31.90-468.70)
> 5 cm	68	135.35 (35.87-524.93)
Local invasion			< 0.001
T1-T2	42	562.75 (299.65-999.73)
T3-T4	127	88.17 (25.50-267.13)
Lymph node metastasis			< 0.001
No	98	300.87 (72.88-740.23)
Yes	71	67.92 (21.22-200.36)
TNM stage			< 0.001
Stage I	34	708.05 (362.41-1054.28)
Stage II	64	132.50 (34.53-421.89)
Stage III	71	67.92 (21.22-200.36)

TNM: Tumor node metastasis; IQR: Interquartile range.

Table 2 Univariate and multivariate analyses for overall survival in colorectal cancer patients

Variable	Univariate analysis				Multivariate analysis
	HR	95%CI	P value		HR	95%CI	P value
Age (yr)	1.107	0.685-1.789	0.679
Sex (male female)	1.154	0.714-1.863	0.559
Tumor location (rectum vs colon)	1.006	0.623-1.625	0.981
Tumor size	1.318	0.814-2.134	0.261
Differentiation	0.788	0.490-1.268	0.326
Local invasion (T3-4 vs T1-2)	4.328	1.780-10.020	0.001		1.196	0.424-3.370	0.735
Lymph node metastasis	2.416	1.488-3.923	< 0.001		0.238	0.033-1.717	0.154
TNM stage	2.336	1.609-3.393	< 0.001		6.111	1.029-36.278	< 0.05
miR-133a expression (high vs low)	0.385	0.232-0.638	< 0.001		0.590	0.350-0.995	< 0.05

TNM: Tumor node metastasis; HR: Hazard ratio.