Kim SH, Jeong JB, Kim JW, Koh SJ, Kim BG, Lee KL, Chang MS, Im JP, Kang HW, Shin CM. Clinical and endoscopic characteristics of drug-induced esophagitis. World J Gastroenterol 2014; 20(31): 10994-10999 [PMID: 25152603 DOI: 10.3748/wjg.v20.i31.10994]
Corresponding Author of This Article
Ji Won Kim, MD, PhD, Associate Professor, Department of Internal Medicine, Seoul National University Boramae Hospital, Seoul National University College of Medicine, 5 Gil 20, Boramae-Road, Dongjak-Gu, 156-707 Seoul, South Korea. kjwjor@snu.ac.kr
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Observational Study
Open-Access Policy of This Article
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World J Gastroenterol. Aug 21, 2014; 20(31): 10994-10999 Published online Aug 21, 2014. doi: 10.3748/wjg.v20.i31.10994
Table 1 Demographic features and clinical symptoms of patients diagnosed with drug-induced esophagitis n (%)
Characteristics
Age(yr)
mean ± SD
43.9 ± 18.9
Sex
Male/female
28/50
Symptom
Chest pain
56 (71.8)
Odynophagia
30 (38.5)
Dysphagia
23 (29.5)
Vomiting
6 (7.7)
Melena
2 (2.6)
Table 2 Endoscopic features of patients diagnosed with drug-induced esophagitis
Feature
n (%)
Location
Proximal
3 (3.8)
Middle
61 (78.2)
Distal
14 (17.9)
Endoscopic findings
Ulcers
64 (82.1)
Bleeding
19 (24.4)
Erosions
14 (17.9)
Coating
4 (5.1)
Pill
3 (3.8)
Stricture
2 (2.6)
Kissing ulcers
34 (43.6)
Table 3 Causative drugs of patients diagnosed with drug-induced esophagitis
Drug
n (%)
Antibiotics
28 (35.9)
NSAID
27 (34.6)
Anti-hypertensive
9 (11.5)
Acetaminophen
7 (9.0)
Oral hypoglycemic
4 (5.1)
Bisphosphonate
4 (5.1)
Ascorbic acid
2 (2.6)
Warfarin
2 (2.6)
Other drugs
4 (5.1)
Table 4 Proportion of antibiotics and non-steroidal anti-inflammatory drugs between both age groups
Age
Total
P value
< 45 yr
≥ 45 yr
Antibiotics
0.020
(+)
20
8
28
(-)
22
28
50
Total
42
36
78
NSAID
(+)
12
15
27
0.226
(-)
30
21
51
Total
42
36
78
Table 5 Pathological findings of drug-induced esophagitis group and reflux esophagitis group n (%)
Drug-induced esophagitis
Reflux esophagitis
P value
(n = 17)
(n = 19)
Basal cell hyperplasia
6 (35.3)
5 (26.3)
0.559
Papillary elongation
5 (29.4)
11 (57.9)
0.086
Dilated intercellular spaces
11 (64.7)
8 (42.1)
0.175
Cell vacuolization
13 (76.5)
9 (47.4)
0.074
Citation: Kim SH, Jeong JB, Kim JW, Koh SJ, Kim BG, Lee KL, Chang MS, Im JP, Kang HW, Shin CM. Clinical and endoscopic characteristics of drug-induced esophagitis. World J Gastroenterol 2014; 20(31): 10994-10999