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World J Gastroenterol. Aug 21, 2014; 20(31): 10994-10999
Published online Aug 21, 2014. doi: 10.3748/wjg.v20.i31.10994
Published online Aug 21, 2014. doi: 10.3748/wjg.v20.i31.10994
Table 1 Demographic features and clinical symptoms of patients diagnosed with drug-induced esophagitis n (%)
Characteristics | ||
Age(yr) | mean ± SD | 43.9 ± 18.9 |
Sex | Male/female | 28/50 |
Symptom | Chest pain | 56 (71.8) |
Odynophagia | 30 (38.5) | |
Dysphagia | 23 (29.5) | |
Vomiting | 6 (7.7) | |
Melena | 2 (2.6) |
Table 2 Endoscopic features of patients diagnosed with drug-induced esophagitis
Feature | n (%) | |
Location | Proximal | 3 (3.8) |
Middle | 61 (78.2) | |
Distal | 14 (17.9) | |
Endoscopic findings | Ulcers | 64 (82.1) |
Bleeding | 19 (24.4) | |
Erosions | 14 (17.9) | |
Coating | 4 (5.1) | |
Pill | 3 (3.8) | |
Stricture | 2 (2.6) | |
Kissing ulcers | 34 (43.6) |
Table 3 Causative drugs of patients diagnosed with drug-induced esophagitis
Drug | n (%) |
Antibiotics | 28 (35.9) |
NSAID | 27 (34.6) |
Anti-hypertensive | 9 (11.5) |
Acetaminophen | 7 (9.0) |
Oral hypoglycemic | 4 (5.1) |
Bisphosphonate | 4 (5.1) |
Ascorbic acid | 2 (2.6) |
Warfarin | 2 (2.6) |
Other drugs | 4 (5.1) |
Table 4 Proportion of antibiotics and non-steroidal anti-inflammatory drugs between both age groups
Age | Total | P value | ||
< 45 yr | ≥ 45 yr | |||
Antibiotics | 0.020 | |||
(+) | 20 | 8 | 28 | |
(-) | 22 | 28 | 50 | |
Total | 42 | 36 | 78 | |
NSAID | ||||
(+) | 12 | 15 | 27 | 0.226 |
(-) | 30 | 21 | 51 | |
Total | 42 | 36 | 78 |
Table 5 Pathological findings of drug-induced esophagitis group and reflux esophagitis group n (%)
Drug-induced esophagitis | Reflux esophagitis | P value | |
(n = 17) | (n = 19) | ||
Basal cell hyperplasia | 6 (35.3) | 5 (26.3) | 0.559 |
Papillary elongation | 5 (29.4) | 11 (57.9) | 0.086 |
Dilated intercellular spaces | 11 (64.7) | 8 (42.1) | 0.175 |
Cell vacuolization | 13 (76.5) | 9 (47.4) | 0.074 |
- Citation: Kim SH, Jeong JB, Kim JW, Koh SJ, Kim BG, Lee KL, Chang MS, Im JP, Kang HW, Shin CM. Clinical and endoscopic characteristics of drug-induced esophagitis. World J Gastroenterol 2014; 20(31): 10994-10999
- URL: https://www.wjgnet.com/1007-9327/full/v20/i31/10994.htm
- DOI: https://dx.doi.org/10.3748/wjg.v20.i31.10994