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©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Aug 21, 2014; 20(31): 10944-10952
Published online Aug 21, 2014. doi: 10.3748/wjg.v20.i31.10944
Published online Aug 21, 2014. doi: 10.3748/wjg.v20.i31.10944
Table 1 Preoperative factors affecting the overall survival and tumor-free survival of hepatocellular carcinoma patients
Category | Subcategory | Overall survival | Tumor-free survival | ||||
Univariate analysis | Multivariate analysis | HR (95%CI) | Univariate analysis | Multivariate analysis | HR (95%CI) | ||
Gender | Male (139) | 0.935 | 0.916 | ||||
Female (33) | |||||||
Age | ≥ 60 yr (55) | 0.090 | 0.233 | ||||
< 60 yr (117) | |||||||
HBV | Yes (121) | 0.044 | 0.012 | 0.556 | 0.084 | ||
No (51) | (0.353-0.878) | ||||||
HCV | Yes (8) | 0.637 | 0.485 | ||||
No (164) | |||||||
Cirrhosis | Yes (59) | 0.321 | 0.141 | ||||
No (113) | |||||||
ALP | > 120 U/L (50) | < 0.001 | 0.008 | 1.866 | < 0.001 | 0.002 | 1.973 |
≤ 120 U/L(122) | (1.176-2.960) | (1.283-3.034) | |||||
GGT | > 115 U/L (48) | < 0.001 | 0.030 | 1.674 | 0.001 | 0.676 | |
≤ 115 U/L (124) | (1.050-2.668) | ||||||
AFP | ≥ 400 ng/mL (66) | 0.085 | 0.001 | 0.017 | 1.685 | ||
< 400 ng/mL (106) | (1.099-2.583) | ||||||
Tumor characteristics | |||||||
Size | ≥ 5 cm (114) | < 0.001 | < 0.001 | 4.472 | < 0.001 | < 0.001 | 4.315 |
< 5 cm (58) | (2.328-8.590) | (2.299-8.099) | |||||
Number | > 1 (32) | 0.143 | 0.218 | ||||
= 1 (140) | |||||||
Invasion | Yes (54) | 0.319 | 0.379 | ||||
No (118) | |||||||
Lymphnode metastasis | Yes (6) | 0.001 | 0.242 | < 0.001 | 0.009 | 3.149 | |
No (166) | (1.329-7.462) |
Table 2 Comparison of baseline characteristics of patients with different alkaline phosphatase, and γ-glutamyltransferase
Factors | ALP > 120(n = 50) | ALP ≤ 120(n = 122) | P value | GGT > 115(n = 48) | GGT ≤ 115(n = 124) | P value |
Gender | 40 | 99 | 0.835 | 40 | 99 | 0.671 |
Age | 19 | 36 | 0.286 | 18 | 37 | 0.365 |
HBV | 34 | 87 | 0.714 | 35 | 86 | 0.712 |
HCV | 2 | 6 | 1.000 | 3 | 5 | 0.687 |
Cirrhosis | 23 | 36 | 0.051 | 20 | 39 | 0.215 |
AFP | 17 | 49 | 0.493 | 21 | 45 | 0.386 |
Tumor characteristics | ||||||
Size | 39 | 75 | 0.050 | 42 | 72 | < 0.001 |
Number | 10 | 22 | 0.830 | 11 | 21 | 0.387 |
Invasion | 9 | 45 | 0.018 | 16 | 38 | 0.719 |
Lymphnode metastasis | 3 | 3 | 0.358 | 4 | 2 | 0.052 |
Table 3 Univariate Cox regression analysis of prognostic scoring model, alpha-fetoprotein level, tumor size and the presence of cirrhosis
P value | HR | 95%CI | |
Low risk | - | - | - |
Middle risk | < 0.001 | 4.250 | 1.927-9.370 |
High risk | < 0.001 | 15.56 | 6.181-39.175 |
AFP | 0.085 | 1.454 | 0.950-2.227 |
Cirrhosis | 0.321 | 0.790 | 0.495-1.259 |
Tumor size | < 0.001 | 5.139 | 2.722-9.703 |
- Citation: Xu XS, Wan Y, Song SD, Chen W, Miao RC, Zhou YY, Zhang LQ, Qu K, Liu SN, Zhang YL, Dong YF, Liu C. Model based on γ-glutamyltransferase and alkaline phosphatase for hepatocellular carcinoma prognosis. World J Gastroenterol 2014; 20(31): 10944-10952
- URL: https://www.wjgnet.com/1007-9327/full/v20/i31/10944.htm
- DOI: https://dx.doi.org/10.3748/wjg.v20.i31.10944