Model based on γ-glutamyltransferase and alkaline phosphatase for hepatocellular carcinoma prognosis

Table 1 Preoperative factors affecting the overall survival and tumor-free survival of hepatocellular carcinoma patients

Category	Subcategory	Overall survival			Tumor-free survival
		Univariate analysis	Multivariate analysis	HR (95%CI)	Univariate analysis	Multivariate analysis	HR (95%CI)
Gender	Male (139)	0.935			0.916
	Female (33)
Age	≥ 60 yr (55)	0.090			0.233
	< 60 yr (117)
HBV	Yes (121)	0.044	0.012	0.556	0.084
	No (51)			(0.353-0.878)
HCV	Yes (8)	0.637			0.485
	No (164)
Cirrhosis	Yes (59)	0.321			0.141
	No (113)
ALP	> 120 U/L (50)	< 0.001	0.008	1.866	< 0.001	0.002	1.973
	≤ 120 U/L(122)			(1.176-2.960)			(1.283-3.034)
GGT	> 115 U/L (48)	< 0.001	0.030	1.674	0.001	0.676
	≤ 115 U/L (124)			(1.050-2.668)
AFP	≥ 400 ng/mL (66)	0.085			0.001	0.017	1.685
	< 400 ng/mL (106)						(1.099-2.583)
Tumor characteristics
Size	≥ 5 cm (114)	< 0.001	< 0.001	4.472	< 0.001	< 0.001	4.315
	< 5 cm (58)			(2.328-8.590)			(2.299-8.099)
Number	> 1 (32)	0.143			0.218
	= 1 (140)
Invasion	Yes (54)	0.319			0.379
	No (118)
Lymphnode metastasis	Yes (6)	0.001	0.242		< 0.001	0.009	3.149
	No (166)						(1.329-7.462)

ALP: Alkaline phosphatase; GGT: γ-glutamyltransferase; AFP: α-fetoprotein; HBV: Hepatitis B virus; HCV: Hepatitis C virus.

Table 2 Comparison of baseline characteristics of patients with different alkaline phosphatase, and γ-glutamyltransferase

Factors	ALP > 120(n = 50)	ALP ≤ 120(n = 122)	P value	GGT > 115(n = 48)	GGT ≤ 115(n = 124)	P value
Gender	40	99	0.835	40	99	0.671
Age	19	36	0.286	18	37	0.365
HBV	34	87	0.714	35	86	0.712
HCV	2	6	1.000	3	5	0.687
Cirrhosis	23	36	0.051	20	39	0.215
AFP	17	49	0.493	21	45	0.386
Tumor characteristics
Size	39	75	0.050	42	72	< 0.001
Number	10	22	0.830	11	21	0.387
Invasion	9	45	0.018	16	38	0.719
Lymphnode metastasis	3	3	0.358	4	2	0.052

ALP: Alkaline phosphatase; GGT: γ-glutamyltransferase; AFP: α-fetoprotein; HBV: Hepatitis B virus; HCV: Hepatitis C virus.

Table 3 Univariate Cox regression analysis of prognostic scoring model, alpha-fetoprotein level, tumor size and the presence of cirrhosis

	P value	HR	95%CI
Low risk	-	-	-
Middle risk	< 0.001	4.250	1.927-9.370
High risk	< 0.001	15.56	6.181-39.175
AFP	0.085	1.454	0.950-2.227
Cirrhosis	0.321	0.790	0.495-1.259
Tumor size	< 0.001	5.139	2.722-9.703

AFP: α-fetoprotein.