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©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Aug 21, 2014; 20(31): 10916-10920
Published online Aug 21, 2014. doi: 10.3748/wjg.v20.i31.10916
Published online Aug 21, 2014. doi: 10.3748/wjg.v20.i31.10916
Table 1 Demographic characteristics and comparison of serum Beta 2 microglobulin levels with other laboratory markers between patients and controls n (%)
Controls | UC | CD | P value | ||
n = 30 | n = 43 | n = 35 | |||
Mean age | 38.90 ± 11.05 | 42.72 ± 13.52 | 38.28 ± 13.15 | 0.254 | |
Gender (F/M) | 18 (60)/12 (40) | 17 (40)/26 (60) | 19 (54)/16 (46) | 0.188 | |
Duration (yr) | 5.04 ± 5.81 | 4.50 ± 3.70 | 0.729 | ||
Inactive/active | 14 (33)/29 (67) | 12 (34)/23 (66) | |||
Left type 29 (67) | Ileal type 24 (69) | ||||
Disease location | Extensive 14 (33) | Ileocolonic 11 (31) | |||
B2-M | 1.71 ± 0.44 | 2.41 ± 0.87 | 2.24 ± 1.01 | 0.002 | UC vs C 0.002 |
CD vs C 0.033 | |||||
UC vs CD 0.642 | |||||
CRP | 0.57 ± 0.83 | 1.82 ± 2.94 | 1.59 ± 2.79 | 0.188 | |
ESR | 10.18 ± 11.31 | 21.21 ± 18.37 | 22.76 ± 22.81 | 0.021 | UC vs C 0.047 |
CD vs C 0.026 | |||||
UC vs CD 0.931 | |||||
WBC (× 103) | 7.09 ± 1.75 | 7.52 ± 2.84 | 7.48 ± 3.91 | 0.190 | |
Albumin | 4.43 ± 0.24 | 4.00 ± 0.62 | 4.05 ± 0.63 | 0.005 | UC vs C 0.006 |
CD vs C 0.023 | |||||
UC vs CD 0.916 |
Table 2 Overall accuracy and receiver operating characteristic analyses of beta 2 microglobulin and other inflammation markers to differentiate active from inactive ulcerative colitis
AUC | Sensitivity (%) | Specificity (%) | NPV (%) | PPV (%) | |
B2-M (cut off: 2.02) | 0.757 | 79.3 | 78.6 | 88.5 | 64.7 |
CRP (cut off: 0.55) | 0.731 | 67.9 | 75.0 | 86.4 | 50.0 |
WBC (× 103) | 0.656 | 72.4 | 58.3 | 80.8 | 46.7 |
(cut off: 6.50) | |||||
ESR (cut off: 14.5) | 0.677 | 69.0 | 58.3 | 80.0 | 43.8 |
Table 3 Comparison of serum beta 2 microglobulin levels with other laboratory markers between active and inactive ulcerative colitis patients
Inactive CD | Active CD | P value | |
n = 14 | n = 29 | ||
B2-M | 1.88 ± 0.41 | 2.66 ± 0.92 | 0.004 |
CRP | 0.41 ± 0.27 | 2.43 ± 3.34 | 0.046 |
ESR | 14.00 ± 7.85 | 24.20 ± 20.65 | 0.106 |
WBC (× 103) | 6.41 ± 1.47 | 7.96 ± 3.16 | 0.119 |
Albumin | 3.99 ± 0.50 | 4.01 ± 0.67 | 0.948 |
Table 4 Comparison of serum beta 2 microglobulin levels with other laboratory markers between active and inactive Crohn’s disease patients
Inactive CDn = 12 | active CDn = 23 | P value | |
B2-M | 1.73 ± 0.31 | 2.50 ± 1.15 | 0.033 |
CRP | 0.24 ± 0.12 | 2.23 ± 3.22 | 0.050 |
ESR | 11.45 ± 11.21 | 28.17 ± 25.08 | 0.044 |
WBC (× 103) | 7.81 ± 2.28 | 7.33 ± 4.53 | 0.742 |
Albumin | 4.50 ± 0.42 | 3.83 ± 0.60 | 0.002 |
Table 5 Overall accuracy and receiver operating characteristic analyses of beta 2 microglobulin and other inflammation markers between active and inactive ulcerative colitis patients
AUC | Sensitivity (%) | Specificity (%) | NPV (%) | PPV (%) | |
B2-M (Cut off: 1.84) | 0.828 | 78.3 | 75.0 | 85.7 | 64.3 |
CRP (Cut off: 0.35) | 0.903 | 78.3 | 81.8 | 90.0 | 64.3 |
WBC (× 103) | 0.379 | 47.8 | 56.5 | 68.8 | 33.3 |
(Cut off: 6.80) | |||||
ESR (Cut off: 13.5) | 0.761 | 78.3 | 72.7 | 85.7 | 61.5 |
- Citation: Yılmaz B, Köklü S, Yüksel O, Arslan S. Serum beta 2-microglobulin as a biomarker in inflammatory bowel disease. World J Gastroenterol 2014; 20(31): 10916-10920
- URL: https://www.wjgnet.com/1007-9327/full/v20/i31/10916.htm
- DOI: https://dx.doi.org/10.3748/wjg.v20.i31.10916