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©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Aug 21, 2014; 20(31): 10900-10907
Published online Aug 21, 2014. doi: 10.3748/wjg.v20.i31.10900
Published online Aug 21, 2014. doi: 10.3748/wjg.v20.i31.10900
Table 1 Characteristics of hepatocellular carcinoma patients and univariate assessment of long-term survival after liver transplantation n (%)
Variables | Value | P value |
Age (yr) | 47.99 ± 9.09 | < 0.001 |
Gender | 0.048 | |
Male | 204 (91.5) | |
Female | 19 (8.5) | |
Blood type | 0.951 | |
A | 66 (29.6) | |
B | 62 (27.8) | |
O | 75 (33.6) | |
AB | 20 (9.0) | |
Identical | 195 (87.4) | 0.492 |
History | ||
Cardiovascular disease | 17 (7.6) | 0.358 |
Respiratory disease | 3 (1.3) | 0.296 |
Diabetes mellitus | 17 (7.6) | 0.736 |
Hepatitis B virus infection | 223 (100.0) | 0.252 |
Ascites | 144 (64.6) | 0.426 |
Variceal bleeding | 25 (11.2) | 0.023 |
Encephalopathy | 4 (1.8) | 0.799 |
Treatment related to hepatocellular carcinoma | ||
Hepatectomy | 21 (9.4) | 0.693 |
Transplantation | 4 (1.8) | < 0.001 |
TACE | 44 (19.7) | 0.756 |
Criteria | ||
Milan | < 0.001 | |
Met | 88 (39.5) | |
Exceeded | 135 (60.5) | |
UCSF | < 0.001 | |
Met | 97 (43.5) | |
Exceeded | 126 (56.5) | |
Shanghai Fudan | < 0.001 | |
Met | 116 (52.0) | |
Exceeded | 107 (48.0) | |
Hangzhou | < 0.001 | |
Met | 144 (64.6) | |
Exceeded | 79 (35.4) | |
MELD score | 14.12 ± 7.02 | 0.086 |
SCr (μmol/L) | 71.41 ± 69.10 | 0.173 |
TB (μmol/L) | 89.45 ± 174.19 | < 0.001 |
INR | 1.42 ± 0.45 | 0.010 |
AFP (ng/mL) | 5694.77 ± 12584.00 | < 0.001 |
Cold ischemia time (h) | 9.21 ± 2.07 | 0.129 |
Intraoperative blood loss (IU) | 9.24 ± 8.50 | 0.002 |
Operation duration (h) | 8.29 ± 1.58 | 0.200 |
Liver transplantation technique | 0.001 | |
Classic | 212 (95.1) | |
Piggyback | 11 (4.9) | |
Biliary reconstruction | < 0.001 | |
Duct-to-duct | 221 (99.1) | |
Roux-en-Y | 2 (0.9) | |
Edmondson grading | 0.790 | |
I | 8 (3.6) | |
II | 200 (89.7) | |
III | 13 (5.8) | |
IV | 2 (0.9) |
Table 2 Long-term survival model for hepatocellular carcinoma patients after liver transplantation
Variables | Regression coefficient | Regression coefficient SE | P value | Hazard ratio | 95%CI |
Milan1 | |||||
AFP (logevalue) | 0.093 | 0.031 | 0.003 | 1.097 | 1.032-1.167 |
Intraoperative blood loss | 0.038 | 0.009 | < 0.001 | 1.039 | 1.021-1.057 |
Retransplantation | 1.429 | 0.522 | 0.006 | 4.173 | 1.501-11.604 |
Criteria exceeded | 1.504 | 0.253 | < 0.001 | 4.500 | 2.741-7.386 |
University of California San Francisco2 | |||||
AFP (logevalue) | 0.090 | 0.031 | 0.003 | 1.094 | 1.030-1.161 |
Intraoperative blood loss | 0.038 | 0.009 | < 0.001 | 1.039 | 1.022-1.057 |
Retransplantation | 1.373 | 0.522 | 0.009 | 3.947 | 1.419-10.976 |
Criteria exceeded | 1.555 | 0.242 | < 0.001 | 4.737 | 2.950-7.607 |
Shanghai Fudan3 | |||||
AFP (logevalue) | 0.091 | 0.031 | 0.003 | 1.096 | 1.031-1.165 |
Intraoperative blood loss | 0.034 | 0.008 | < 0.001 | 1.035 | 1.018-1.052 |
Retransplantation | 1.296 | 0.523 | 0.013 | 3.654 | 1.311-10.182 |
Criteria exceeded | 1.361 | 0.213 | < 0.001 | 3.899 | 2.566-5.924 |
Hangzhou4 | |||||
TB (logevalue) | 0.186 | 0.094 | 0.049 | 1.204 | 1.001-1.449 |
Intraoperative blood loss | 0.020 | 0.010 | 0.046 | 1.020 | 1.000-1.040 |
Retransplantation | 1.312 | 0.520 | 0.012 | 3.715 | 1.340-10.295 |
Criteria exceeded | 1.520 | 0.190 | < 0.001 | 4.570 | 3.149-6.633 |
- Citation: Teng F, Wang GH, Tao YF, Guo WY, Wang ZX, Ding GS, Shi XM, Fu ZR. Criteria-specific long-term survival prediction model for hepatocellular carcinoma patients after liver transplantation. World J Gastroenterol 2014; 20(31): 10900-10907
- URL: https://www.wjgnet.com/1007-9327/full/v20/i31/10900.htm
- DOI: https://dx.doi.org/10.3748/wjg.v20.i31.10900