Research Report
Copyright ©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Aug 14, 2014; 20(30): 10449-10456
Published online Aug 14, 2014. doi: 10.3748/wjg.v20.i30.10449
Table 1 Characteristics of the study population
HCV
Healthy subjects
Pvalue
MedianLQ-UQMin-MaxMedianLQ-UQMin-Max
Age3223-4818-613223-4826-56P > 0.05
BMI23.623.2-24.720.1-24.923.322.4-24.719.5-24.9P > 0.05
ALT U/L5243-7923-339
HCV viremia (IU/mL)1230000382000-3880000112000-8950000
SOCS-35.172.09-9.780.5-24.53
HOMA2.241.50-3.360.78-9.670.560.34-1.020.25-2P = 0.0003
Visfatin (ng/mL)2.641.17-3.580.45-9.372.752.47-3.81.26-5.27P > 0.05
Omentin (ng/mL)385.07340.33-522.77115.7-757.34375.55278.02-477.33115.68-587.51P > 0.05
Adiponectin (µg/mL)7.235.48-8.723.51-18.489.3356.275-11.205.89-15.33P > 0.05
Resistin (ng/mL)1.541.11-1.740.73-2.921.481.31-1.711.04-2.7P > 0.05
Leptin (ng/mL)4.852.425-13.60.77-54.655.7853.81-17.061.85-42.76P > 0.05
Osteopontin (ng/mL)28.7118.06-36.195.33-59.1520.5615.47-21.26.14-32.42P > 0.05
Number of patients (n)Number of patients (n)
Age > 4094P > 0.05
Age < 40225
Women104P > 0.05
Men215
Table 2 Adipokines and homeostasis model assessment of insulin resistance in chronic hepatitis C
Median (LQ-UQ)
Pvalue
HOMA-IR > 2.5 (n= 15)HOMA-IR < 2.5 (n= 16)
Omentin (ng/mL)381.24 (332.79- 483.33)399.91 (367.16-541.72)P > 0.05
Adiponectin (μg/mL)6.24 (5.48-7.92)8.37 (5.63-12.18)P > 0.05
Resistin (ng/mL)1.56 (1.42-1.74)1.24 (1.03-1.56)P > 0.05
Leptin (ng/mL)6.79 (2.34-13.11)3.04 (2.51-17.2)P > 0.05
Visfatin (ng/mL)2.66 (1.09-3.12)2.05 (1.17-3.3)P > 0.05
Osteopontin (ng/mL)28.71 (15.52-37.1)31.18 (20.29-36.07)P > 0.05
Table 3 Adipokines and liver steatosis in chronic hepatitis C
With steatosis (n= 10)
Without steatosis (n= 21)
Pvalue
Median (LQ-UQ)Min-maxMedian (LQ-UQ)Min-max
SOCS36.553 (3.393-11.777)1.042-24.5375.106 (2.095-8.713)0.5-17.95P > 0.05
HOMA2.815 (1.99-4.84)1.25-9.671.995 (1.21-2.51)0.78-7.25P = 0.05
Adiponectin (μg/mL)5.985 (4.83-7.23)3.55-8.438.37 (5.71-9.07)3.51-18.48P = 0.047
Osteopontin (ng/mL)33.51 (15.52-49.12)5.33-59.1524.7 (18.26-34.58)11.57-47.85P > 0.05
Leptin (ng/mL)5.705 (3.04-17.2)2.34-54.653.825 (1.33-13.11)0.77-39.04P > 0.05
Resistin (ng/mL)1.65 (1.42-1.84)1.17-2.361.51 (1.03-1.58)0.73-2.92P > 0.05
Omentin (ng/mL)374.875 (332.79-483.33)227.99-757.34393.92 (360.09-522.77)115.7-735.84P > 0.05
Visfatin (ng/mL)2.465 (1.37-3.12)0.45-3.972.64 (1.17-4.08)0.53-9.37P > 0.05
Table 4 Adipokines and liver inflammation in chronic hepatitis C
G2 (n= 9)
G < 2 (n= 22)
Pvalue
Median (LQ-UQ)Min-maxMedian (LQ-UQ)Min-max
Omentin (ng/mL)381.24 (367.16-522.77)115.7-757.34389.46 (340.33-483.33)227.99-735.84P > 0.05
Adiponectin (μg/mL)6.21 (5.71-7.56)4.6-9.078 (5.48-9.06)3.51-18.24P > 0.05
Resistin (ng/mL)1.24 (1.17-1.65)0.91-2.361.55 (1.11-1.82)0.73-2.92P > 0.05
HOMA2.1(1.59-3.99)0.78-9.672.38 (1.25-2.84)0.88-7.25P > 0.05
Leptin (ng/mL)10.83 (4.26-31.44)1.69-54.653.43 (1.83-9.36)0.77-39.04P > 0.05
Visfatin (ng/mL)2.05 (1.83-2.66)0.65-8.892.78 (1.17-4.08)0.45-9.37P > 0.05
Osteopontin (ng/mL)34.04 (32.7-36.19)22.47-49.1223.25 (15.05-36.07)5.33-59.15P = 0.03
SOCS-33.69 (2.67-7.05)0.66-11.528.13 (1.74-11.78)0.5-24.53P > 0.05
Table 5 Adipokines and liver fibrosis in chronic hepatitis C
S2 (n= 22)
S < 2 (n= 9)
Pvalue
Median (LQ-UQ)Min-maxMedian (LQ-UQ)Min-max
Omentin (ng/mL)436.94 (367.16-538.15)115.7-757.34360.09 (296.34-383.55)257.55-396.92P = 0.03
Adiponectin (μg/mL)7.39 (5.71-9.06)4.6-18.486.46 (4.52-8.37)3.51-11.28P > 0.05
Resistin (ng/mL)1.4 (1.03-1.58)0.73-2.361.74 (1.54-2.67)0.76-2.92P = 0.047
HOMA (mmol/L)2.1 (1.33-3.36)0.78-9.772.5 (1.5-2.79)0.88-5.17P > 0.05
Leptin (ng/mL)4.09 (2.51-8.56)1.00-54.6511.94 (1.17-21.5)0.77-39.04P > 0.05
Visfatin (ng/mL)2.25 (1.17-3.3)0.53-8.893.12 (1.57-5.26)0.45-9.37P > 0.05
Osteopontin (ng/mL)32.84 (22.47-37.1)8.46-59.1520.29 (15.05-24.33)5.33-38.46P = 0.03
SOCS-34.51 (1.92-9.24)0.66-24.538.61 (4.40-11.777)0.5-17.95P > 0.05
Table 6 Correlations between adipokines and hepatic expression of suppressor of cytokine signaling 3 in chronic hepatitis C
SOCS-3Pvalue
Spearman’s rank correlationρ
Age0.12P > 0.05
HCV viral load (IU/mL)0.15P > 0.05
ALT (U/L)0.41P > 0.05
HOMA0.39P > 0.05
Adiponectin (μg/mL)0.24P > 0.05
Osteopontin (ng/mL)0.30P > 0.05
Visfatin (ng/mL)0.23P > 0.05
Resistin (ng/mL)0.55P > 0.05
Leptin (ng/mL)0.14P > 0.05
Omentin (ng/mL)0.50P > 0.05
Table 7 Adipokines and hepatitis C virus viremia
VL600000 IU/mL (n= 12)
VL < 600000 IU/mL (n= 19)
Pvalue
Median (LQ-UQ)Min-maxMedian (LQ-UQ)Min-max
Age32 (23-54)18-6132.5 (23.5-38)18-61P > 0.05
Adiponectin (μg/mL)6.46 (5.48-8.72)3.51-18.487.42 (5.48-8.75)3.55-17.93P > 0.05
Osteopontin (ng/mL)31.18 (15.52-37.1)11.57-59.1526.84 (21.19-33.78)5.33-54.98P > 0.05
Leptin (ng/mL)4.09 (1.59-21.5)0.77-54.655.47 (2.51-13.11)1.17-17.2P > 0.05
Resistin (ng/mL)1.42 (1.03-1.74)0.73-2.921.56 (1.29-1.78)0.87-2.71P > 0.05
Omentin (ng/mL)393.92 (342.46-534.21)115.7-757.34381.88 (312.96-497.43)227.99-735.84P > 0.05
HOMA2.01 (1.5-3.99)0.88-9.672.5 (1.25-3.36)0.78-5.66P > 0.05
Visfatin (ng/mL)2.67 (1.17-3.97)0.53-9.372.14 (1.23-3.11)0.45-9.33P > 0.05
Table 8 Adipokines and single nucleotide polymorphisms of interleukin 28B in chronic hepatitis C
CC (n= 6)
TT/CT (n= 25)
Pvalue
Median (LQ-UQ)Min-maxMedian (LQ-UQ)Min-max
SOCS-311.52 (3.164-15.738)2.17-17.955.10 (1.75-8.713)0.5-24.537P > 0.05
HCV viremia (IU/mL)1195000 (362000-3830000)112000-98500003780000 (799000-4290000)382000-7210000P > 0.05
ALT (U/L)54 (43-83)23-33945 (44-47)41-48P > 0.05
HOMA(1.02-3.99)0.78-5.662.44 (1.5-2.84)0.88-9.67P > 0.05
Adiponectin (μg/mL)7.56 (6-8.37)5.33-9.076.35 (5.34-8.89)3.51-18.48P > 0.05
Osteopontin (ng/mL)24.33 (22.18-32.98)13.14-34.5829.94 (16.79-37.78)5.33-59.15P > 0.05
Visfatin (ng/mL)2.64 (1.57-6.35)0.65-9.332.56 (1.13-5.69)0.45-9.37P > 0.05
Leptin (ng/mL)13.11 (8.56-17.2)5.47-39.043.04 (1.69-11.94)0.77-54.65P > 0.05
Omentin (ng/mL)367.16 (257.55-399.91)152.74-522.77390.95 (341.39-536.18)115.7-757.34P > 0.05
Resistin (ng/mL)1.17 (0.91-1.65)0.76-1.741.55 (1.205-1.83)0.73-2.92P > 0.05