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©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Aug 14, 2014; 20(30): 10449-10456
Published online Aug 14, 2014. doi: 10.3748/wjg.v20.i30.10449
Published online Aug 14, 2014. doi: 10.3748/wjg.v20.i30.10449
Table 1 Characteristics of the study population
HCV | Healthy subjects | Pvalue | |||||
Median | LQ-UQ | Min-Max | Median | LQ-UQ | Min-Max | ||
Age | 32 | 23-48 | 18-61 | 32 | 23-48 | 26-56 | P > 0.05 |
BMI | 23.6 | 23.2-24.7 | 20.1-24.9 | 23.3 | 22.4-24.7 | 19.5-24.9 | P > 0.05 |
ALT U/L | 52 | 43-79 | 23-339 | ||||
HCV viremia (IU/mL) | 1230000 | 382000-3880000 | 112000-8950000 | ||||
SOCS-3 | 5.17 | 2.09-9.78 | 0.5-24.53 | ||||
HOMA | 2.24 | 1.50-3.36 | 0.78-9.67 | 0.56 | 0.34-1.02 | 0.25-2 | P = 0.0003 |
Visfatin (ng/mL) | 2.64 | 1.17-3.58 | 0.45-9.37 | 2.75 | 2.47-3.8 | 1.26-5.27 | P > 0.05 |
Omentin (ng/mL) | 385.07 | 340.33-522.77 | 115.7-757.34 | 375.55 | 278.02-477.33 | 115.68-587.51 | P > 0.05 |
Adiponectin (µg/mL) | 7.23 | 5.48-8.72 | 3.51-18.48 | 9.335 | 6.275-11.20 | 5.89-15.33 | P > 0.05 |
Resistin (ng/mL) | 1.54 | 1.11-1.74 | 0.73-2.92 | 1.48 | 1.31-1.71 | 1.04-2.7 | P > 0.05 |
Leptin (ng/mL) | 4.85 | 2.425-13.6 | 0.77-54.65 | 5.785 | 3.81-17.06 | 1.85-42.76 | P > 0.05 |
Osteopontin (ng/mL) | 28.71 | 18.06-36.19 | 5.33-59.15 | 20.56 | 15.47-21.2 | 6.14-32.42 | P > 0.05 |
Number of patients (n) | Number of patients (n) | ||||||
Age > 40 | 9 | 4 | P > 0.05 | ||||
Age < 40 | 22 | 5 | |||||
Women | 10 | 4 | P > 0.05 | ||||
Men | 21 | 5 |
Table 2 Adipokines and homeostasis model assessment of insulin resistance in chronic hepatitis C
Median (LQ-UQ) | Pvalue | ||
HOMA-IR > 2.5 (n= 15) | HOMA-IR < 2.5 (n= 16) | ||
Omentin (ng/mL) | 381.24 (332.79- 483.33) | 399.91 (367.16-541.72) | P > 0.05 |
Adiponectin (μg/mL) | 6.24 (5.48-7.92) | 8.37 (5.63-12.18) | P > 0.05 |
Resistin (ng/mL) | 1.56 (1.42-1.74) | 1.24 (1.03-1.56) | P > 0.05 |
Leptin (ng/mL) | 6.79 (2.34-13.11) | 3.04 (2.51-17.2) | P > 0.05 |
Visfatin (ng/mL) | 2.66 (1.09-3.12) | 2.05 (1.17-3.3) | P > 0.05 |
Osteopontin (ng/mL) | 28.71 (15.52-37.1) | 31.18 (20.29-36.07) | P > 0.05 |
Table 3 Adipokines and liver steatosis in chronic hepatitis C
With steatosis (n= 10) | Without steatosis (n= 21) | Pvalue | |||
Median (LQ-UQ) | Min-max | Median (LQ-UQ) | Min-max | ||
SOCS3 | 6.553 (3.393-11.777) | 1.042-24.537 | 5.106 (2.095-8.713) | 0.5-17.95 | P > 0.05 |
HOMA | 2.815 (1.99-4.84) | 1.25-9.67 | 1.995 (1.21-2.51) | 0.78-7.25 | P = 0.05 |
Adiponectin (μg/mL) | 5.985 (4.83-7.23) | 3.55-8.43 | 8.37 (5.71-9.07) | 3.51-18.48 | P = 0.047 |
Osteopontin (ng/mL) | 33.51 (15.52-49.12) | 5.33-59.15 | 24.7 (18.26-34.58) | 11.57-47.85 | P > 0.05 |
Leptin (ng/mL) | 5.705 (3.04-17.2) | 2.34-54.65 | 3.825 (1.33-13.11) | 0.77-39.04 | P > 0.05 |
Resistin (ng/mL) | 1.65 (1.42-1.84) | 1.17-2.36 | 1.51 (1.03-1.58) | 0.73-2.92 | P > 0.05 |
Omentin (ng/mL) | 374.875 (332.79-483.33) | 227.99-757.34 | 393.92 (360.09-522.77) | 115.7-735.84 | P > 0.05 |
Visfatin (ng/mL) | 2.465 (1.37-3.12) | 0.45-3.97 | 2.64 (1.17-4.08) | 0.53-9.37 | P > 0.05 |
Table 4 Adipokines and liver inflammation in chronic hepatitis C
G≥2 (n= 9) | G < 2 (n= 22) | Pvalue | |||
Median (LQ-UQ) | Min-max | Median (LQ-UQ) | Min-max | ||
Omentin (ng/mL) | 381.24 (367.16-522.77) | 115.7-757.34 | 389.46 (340.33-483.33) | 227.99-735.84 | P > 0.05 |
Adiponectin (μg/mL) | 6.21 (5.71-7.56) | 4.6-9.07 | 8 (5.48-9.06) | 3.51-18.24 | P > 0.05 |
Resistin (ng/mL) | 1.24 (1.17-1.65) | 0.91-2.36 | 1.55 (1.11-1.82) | 0.73-2.92 | P > 0.05 |
HOMA | 2.1(1.59-3.99) | 0.78-9.67 | 2.38 (1.25-2.84) | 0.88-7.25 | P > 0.05 |
Leptin (ng/mL) | 10.83 (4.26-31.44) | 1.69-54.65 | 3.43 (1.83-9.36) | 0.77-39.04 | P > 0.05 |
Visfatin (ng/mL) | 2.05 (1.83-2.66) | 0.65-8.89 | 2.78 (1.17-4.08) | 0.45-9.37 | P > 0.05 |
Osteopontin (ng/mL) | 34.04 (32.7-36.19) | 22.47-49.12 | 23.25 (15.05-36.07) | 5.33-59.15 | P = 0.03 |
SOCS-3 | 3.69 (2.67-7.05) | 0.66-11.52 | 8.13 (1.74-11.78) | 0.5-24.53 | P > 0.05 |
Table 5 Adipokines and liver fibrosis in chronic hepatitis C
S≥2 (n= 22) | S < 2 (n= 9) | Pvalue | |||
Median (LQ-UQ) | Min-max | Median (LQ-UQ) | Min-max | ||
Omentin (ng/mL) | 436.94 (367.16-538.15) | 115.7-757.34 | 360.09 (296.34-383.55) | 257.55-396.92 | P = 0.03 |
Adiponectin (μg/mL) | 7.39 (5.71-9.06) | 4.6-18.48 | 6.46 (4.52-8.37) | 3.51-11.28 | P > 0.05 |
Resistin (ng/mL) | 1.4 (1.03-1.58) | 0.73-2.36 | 1.74 (1.54-2.67) | 0.76-2.92 | P = 0.047 |
HOMA (mmol/L) | 2.1 (1.33-3.36) | 0.78-9.77 | 2.5 (1.5-2.79) | 0.88-5.17 | P > 0.05 |
Leptin (ng/mL) | 4.09 (2.51-8.56) | 1.00-54.65 | 11.94 (1.17-21.5) | 0.77-39.04 | P > 0.05 |
Visfatin (ng/mL) | 2.25 (1.17-3.3) | 0.53-8.89 | 3.12 (1.57-5.26) | 0.45-9.37 | P > 0.05 |
Osteopontin (ng/mL) | 32.84 (22.47-37.1) | 8.46-59.15 | 20.29 (15.05-24.33) | 5.33-38.46 | P = 0.03 |
SOCS-3 | 4.51 (1.92-9.24) | 0.66-24.53 | 8.61 (4.40-11.777) | 0.5-17.95 | P > 0.05 |
Table 6 Correlations between adipokines and hepatic expression of suppressor of cytokine signaling 3 in chronic hepatitis C
SOCS-3 | Pvalue | |
Spearman’s rank correlationρ | ||
Age | 0.12 | P > 0.05 |
HCV viral load (IU/mL) | 0.15 | P > 0.05 |
ALT (U/L) | 0.41 | P > 0.05 |
HOMA | 0.39 | P > 0.05 |
Adiponectin (μg/mL) | 0.24 | P > 0.05 |
Osteopontin (ng/mL) | 0.30 | P > 0.05 |
Visfatin (ng/mL) | 0.23 | P > 0.05 |
Resistin (ng/mL) | 0.55 | P > 0.05 |
Leptin (ng/mL) | 0.14 | P > 0.05 |
Omentin (ng/mL) | 0.50 | P > 0.05 |
Table 7 Adipokines and hepatitis C virus viremia
VL≥600000 IU/mL (n= 12) | VL < 600000 IU/mL (n= 19) | Pvalue | |||
Median (LQ-UQ) | Min-max | Median (LQ-UQ) | Min-max | ||
Age | 32 (23-54) | 18-61 | 32.5 (23.5-38) | 18-61 | P > 0.05 |
Adiponectin (μg/mL) | 6.46 (5.48-8.72) | 3.51-18.48 | 7.42 (5.48-8.75) | 3.55-17.93 | P > 0.05 |
Osteopontin (ng/mL) | 31.18 (15.52-37.1) | 11.57-59.15 | 26.84 (21.19-33.78) | 5.33-54.98 | P > 0.05 |
Leptin (ng/mL) | 4.09 (1.59-21.5) | 0.77-54.65 | 5.47 (2.51-13.11) | 1.17-17.2 | P > 0.05 |
Resistin (ng/mL) | 1.42 (1.03-1.74) | 0.73-2.92 | 1.56 (1.29-1.78) | 0.87-2.71 | P > 0.05 |
Omentin (ng/mL) | 393.92 (342.46-534.21) | 115.7-757.34 | 381.88 (312.96-497.43) | 227.99-735.84 | P > 0.05 |
HOMA | 2.01 (1.5-3.99) | 0.88-9.67 | 2.5 (1.25-3.36) | 0.78-5.66 | P > 0.05 |
Visfatin (ng/mL) | 2.67 (1.17-3.97) | 0.53-9.37 | 2.14 (1.23-3.11) | 0.45-9.33 | P > 0.05 |
Table 8 Adipokines and single nucleotide polymorphisms of interleukin 28B in chronic hepatitis C
CC (n= 6) | TT/CT (n= 25) | Pvalue | |||
Median (LQ-UQ) | Min-max | Median (LQ-UQ) | Min-max | ||
SOCS-3 | 11.52 (3.164-15.738) | 2.17-17.95 | 5.10 (1.75-8.713) | 0.5-24.537 | P > 0.05 |
HCV viremia (IU/mL) | 1195000 (362000-3830000) | 112000-9850000 | 3780000 (799000-4290000) | 382000-7210000 | P > 0.05 |
ALT (U/L) | 54 (43-83) | 23-339 | 45 (44-47) | 41-48 | P > 0.05 |
HOMA | (1.02-3.99) | 0.78-5.66 | 2.44 (1.5-2.84) | 0.88-9.67 | P > 0.05 |
Adiponectin (μg/mL) | 7.56 (6-8.37) | 5.33-9.07 | 6.35 (5.34-8.89) | 3.51-18.48 | P > 0.05 |
Osteopontin (ng/mL) | 24.33 (22.18-32.98) | 13.14-34.58 | 29.94 (16.79-37.78) | 5.33-59.15 | P > 0.05 |
Visfatin (ng/mL) | 2.64 (1.57-6.35) | 0.65-9.33 | 2.56 (1.13-5.69) | 0.45-9.37 | P > 0.05 |
Leptin (ng/mL) | 13.11 (8.56-17.2) | 5.47-39.04 | 3.04 (1.69-11.94) | 0.77-54.65 | P > 0.05 |
Omentin (ng/mL) | 367.16 (257.55-399.91) | 152.74-522.77 | 390.95 (341.39-536.18) | 115.7-757.34 | P > 0.05 |
Resistin (ng/mL) | 1.17 (0.91-1.65) | 0.76-1.74 | 1.55 (1.205-1.83) | 0.73-2.92 | P > 0.05 |
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Citation: Wójcik K, Jabłonowska E, Omulecka A, Piekarska A. Insulin resistance, adipokine profile and hepatic expression of
SOCS-3 gene in chronic hepatitis C. World J Gastroenterol 2014; 20(30): 10449-10456 - URL: https://www.wjgnet.com/1007-9327/full/v20/i30/10449.htm
- DOI: https://dx.doi.org/10.3748/wjg.v20.i30.10449