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World J Gastroenterol. Aug 14, 2014; 20(30): 10449-10456
Published online Aug 14, 2014. doi: 10.3748/wjg.v20.i30.10449
Published online Aug 14, 2014. doi: 10.3748/wjg.v20.i30.10449
Insulin resistance, adipokine profile and hepatic expression of SOCS-3 gene in chronic hepatitis C
Kamila Wójcik, Elżbieta Jabłonowska, Anna Piekarska, Department of Infectious Diseases and Hepatology, Medical University of Lodz, 91-347 Łódź, Poland
Aleksandra Omulecka, Department of Pathology, Bieganski Hospital of Lodz, 91-347 Łódź, Poland
Author contributions: Wójcik K and Jablonowska E contributed equally to this work; Wójcik K, Jablonowska E and Piekarska A designed the research; Wójcik K, Jabłonowska E and Omulecka A performed the research; Wójcik K and Jabłonowska E analyzed the data; Wójcik K and Jabłonowska E wrote the paper.
Supported by Medical University, Lodz, Poland, No. 502-03/1-117-01/502-14-061
Correspondence to: Kamila Wójcik, MD, PhD, Department of Infectious Diseases and Hepatology, Medical University of Łódź, Kniaziewicza 1/5, 91-347 Łódź, Poland. camilaw@tlen.pl
Telephone: +48-42-2516265 Fax: +48-42-2516180
Received: October 8, 2013
Revised: May 4, 2014
Accepted: May 23, 2014
Published online: August 14, 2014
Processing time: 314 Days and 11.3 Hours
Revised: May 4, 2014
Accepted: May 23, 2014
Published online: August 14, 2014
Processing time: 314 Days and 11.3 Hours
Core Tip
Core tip: To investigate the direct effect of hepatitis C virus (HCV) on insulin resistance we analyzed adipokines and homeostasis model assessment for insulin resistance (HOMA-IR) in selected chronic hepatitis C patients without metabolic disorders. In this group of patients we confirmed higher HOMA-IR values compared to healthy subjects. We speculated that no relationship between adipokines and HOMA-IR values may indicate that HCV can induce insulin resistance itself, regardless of metabolic disorders. This is the first study to determine the impact of a wide spectrum of adipokines and HOMA-IR index on histopathological changes in liver biopsy specimens and hepatic expression of suppressor of cytokine signaling 3 mRNA.