Fever as a first manifestation of advanced gastric adenosquamous carcinoma: A case report

Table 1 Reported cases of gastric adenosquamous carcinoma

Author	Year	Country	Gender	Age (yr)	Signs and symptoms	Preop diagnosis	Surgical procedure	Tumor size (cm)	Location	Metastasis	Staging	Adjuvant treatment	Prognosis
Rolleston and Trevor[12]	1905	-	M	39	-	-	-	-	P	-	-	-	-
Lubarsch[12]	1906	-	-	-	-	-	-	-	P	-	-	-	-
Herxheime[12]	1907	-	-	-	-	-	-	-	P	-	-	-	-
Boedeker[12]	1926	-	F	35	-	-	-	-	P	-	-	-	-
			F	65	-	-	-	-	P	-	-	-	-
Oberling and Wolf[12]	1927	-	F	67	-	-	-	-	P	-	-	-	-
Pasternackv[12]	1935	-	M	48	-	-	-	-	P	-	-	-	-
Martin and Pollosson[12]	1936	-	F	64	-	-	-	-	B	-	-	-	-
Takagi[12]	1937	-	M	33	-	-	-	-	B	-	-	-	-
Scheffler and Falk[12]	1940	-	M	74	-	-	-	-	B	-	-	-	-
Wood[12]	1943	-	M	51	-	-	-	-	P	-	-	-	-
			M	37	-	-	-	-	P	-	-	-	-
Strassman[12]	1946	-	M	85	-	-	-	-	B	-	-	-	-
O'Brien and Meehan[12]	1950	-	M	40	-	-	-	-	P	-	-	-	-
Milanes et al[12]	1950	-	M	50	-	-	-	-	B	-	-	-	-
Bellagie and Dahlin[12]	1951	-	M	42	-	-	-	-	B	-	-	-	-
			M	49	-	-	-	-	B	-	-	-	-
Hirai et al[12]	1963	-	M	37	-	-	-	-	B and P	-	-	-	-
Straus, Heschel and Fortmann[12]	1968	-	F	70	-	-	-	-	P	-	-	-	-
Lee et al[1]	1970	SK	M	43	A2, EP, HP, TS		Sub-G + O		A	LN
Taira et al[13]	1976	J	F	45	-	-	-	-	-	-	-	-	-
Fujitomi et al[14]	1983	J	-	-	-	-	-	-	-	-	Bor IV	-	-
Jalif et al[15]	1984	S1	F	68	-	-	-	-	-	-	-	-	-
Sato et al[16]	1984	J	F	76	-	-	TG + S	-	-	-	Bor III	-	-
Matsumoto et al[17]	1984	J	M	56	UAD	-	TG	5.0 × 4.0	A and B	LN	Bor III	-	-
Masuda et al[18]	1985	J	-	53	UAP	ASC	Sub-G	-	B	-	Bor III	-	-
3Horikawa et al[19]	1987	J	F	56	-	-	-	-	-	-	EGC	-	-
3Johzaki et al[20]	1988	J	F	78	-	-	Par-G	-	-	-	EGC	-	-
3Butov et al[21]	1989	R	-	-	-	-	-	-	-	-	EGC	-	-
Shigematsu et al[22]	1989	J	F	74	EP + AL	-	-	-	-	LN	Bor III	-	-
4Yamamoto et al[23]	1989	J	M	61		-	Sub-G	-	-	L, L1 LN	-	-	-
Honda et al[24]	1990	J	M	57	UAP	-	-	-	Angle region	-	Grade II ASC	-	-
Tsukino et al[25]	1990	J	M	61	-	-	-	-	-	LN	Bor IV	-	-
Kawabe et al[26]	1990	J	-	-	-	-	-	-	Fornix and B	-	-	-	-
Coard et al[27]	1991	J and C	-	-	-	-	-	-	-	-	-	-	-
Tenma et al[28]	1993	J	M	51	-	-	TG post chemo	-	-	-ve	Bor III	-	-
Ito et al[29]	1993	J	-	-	-	-	-	-	-	-	-	-	-
Cabello Rodríguez et al[30]	1994	S1	F	84	-	-	-	-	A	-	-	-	-
Toyota et al[6]	1996	J	F	72	RHE	-	P	-	-	-	Bor 2 + EGC	-	-
3Yoshida et al[5]	1996	J	M	66	EP	SCC	Par-DG	2.1 × 2.0	A	L, LN	-	-	Died 2 yr post op2
Manna et al[31]	1998	P	M	55	-	-	-	-	-	-	-	-	-
Mori et al[32]	2000	J	M	59	-	-	TG + H	-	RS	L, LN	-	-	Died 2 mo post H1
Blázquez et al[33]	2005	S1	F	56	CA	-	-	-	A	-	-	-	Died few days post op
Endo et al[7]	2005	J	M	55	F and A1	ASC	Par-G + D3	7.0 × 8.0	A	LN, L2	T2N2M0	-	-
Nomura et al[34]	2006	J	F	62	A1	-	DG	B and A	-	LN	T3N3M0	Neoadjuvant chemo	-
Terada[35]	2009	J	F	87	N and V	SCC	TG + C1 + S	10 × 8 × 7	-	SM, LV	Bor IV	-	Died 5 mo post op
			F	77	EP	SCC	G	6 × 5 × 7	-	SM, LV	Bor III	-	Died 8 mo post op
Faria et al[2]	2010	P	F	84	EP	-ve	Sub-G	8 × 5 × 1.1	A	LN, L	T3N1M1	-	-
Fukuda et al[36]	2012	J	M	70	-	-	TG + D2 + H	-	-	L	-	-	-
Ebi et al[8]	2012	J	M	74	AP and M	SCC	Par-G	-	B	LN	Advanced type 3	S1 monotherapy	Alive post op 2 yr 10 mo
Saito et al[37]	2013	J	M	60	UBP	ASC	No surgery	-	B-A	LN	-	DC-S1	Pt died 3 mo post chemo
3Kimura et al[41]	2013	J	M	77	-	-	LADG	-	-	LN; Recurrence in liver	ECG	S-1 and cisplatin (CDDP)	Alive 14 mo post op
Harsha Ajoodhea et al (present case)	2013	C	M	73	Fever	ADC	TLTG+D2	8 × 7.5	B-A	-ve	T4a N0 M0	Rand S1	Alive at 20 mo post op

¹Died of lymphangitis carcinomatosa of the lung 2 mo after right hepatectomy;

²Died of liver failure due to multiple metastases 2 yr after operation;

³Early gastric cancer;

⁴Hypesthesia and pain in both legs, and progressive difficulty in walking. A1: Anemia; A2: Anorexia; AL: Appetite loss; CA: Chronic anemia; EP: Epigastric pain; HP: Hunger pain; F: Fatigue; V: Vomiting; N: Nausea; RHE: Routine health examination; TS: Tarry stool; M: Melena; UAP: Upper abdominal pain; UAD: Upper abdominal discomfort; J: Japan; S1: Spain; P: Portugal; M: Maroc; C: China; R: Russia; SK: South Korea; JC: Jamaica and Commonwealth Caribbean; S: Splenectomy; Sub-G: Subtotal gastrectomy; Par-G: Partial gastrectomy; P: Pylorogastrectomy; H: Hepatectomy; DG: Distal gastrectomy; C1: Cholecystectomy; ASC: Adenosquamous carcinoma; Par-DG: Partial distal gastrectomy; SSC: Squamous cell carcinoma; ADC: Adenocarcinoma; A: Antrum; B: Body; F: Fornix; C: Cardia; P: Pylorus; O: Omentectomy; RS: Remnant stomach; Borr: Borrmann type; L: liver; L1: Lung; SM: Systemic metastases; LN: Lymph node metastases; LV: Lymphovascular metastases; L2: Lymphatics; R: Radiotherapy; S1: S1 chemotherapy; DC-S1: Docetaxel, cisplatin and S-1 (DCS); EGC: Early gastric cancer; LADG: Laparoscopic-assisted distal gastrectomy; TLTG: Totally laparoscopic total gastrectomy.

Table 2 Reported case series of gastric adenosquamous carcinoma

Author	Year	Country	No. of cases	Mean age (yr)	Location
Boswell and Helwig[12]	1965	-	111	49.1	P: 9 pts; LC: 1 pt; F: 1 pt
Urban et al[12]	1966	-	102	54.7	P and B: 1 pt; C and B: 1 pt
					P: 6 pts; C: 2 pts
Aoki et al[38]	1978	Japan	113	61.2	A: 5 pts; B: 2 pts; F: 4 pts
Mori et al[4]	1986	Japan	28	-	-
Namatame et al[39]	1986	Japan	54	62.8	Lower body along lesser curvature
Rottenberg[40]	1987	Russia	5	-	B and P

¹10 males and 1 female;

²6 males and 1 female;

³10 males and 1 female;

⁴2 males and 3 females. Pt: Patient; A: Antrum of stomach; P: Pylorus; LC: Lesser curvature of stomach; F: Fundus of stomach; B: Body of stomach; C: Cardia of stomach.