Helicobacter pylori associated chronic gastritis, clinical syndromes, precancerous lesions, and pathogenesis of gastric cancer development

Table 1 Operative link for gastritis assessment staging system

Atrophy score		Corpus
		No atrophy	Mild atrophy	Moderate atrophy	Severe atrophy
		(score 0)	(score 1)	(score 2)	(score 3)
Antrum	No atrophy (score 0) (including incisura angularis)	Stage 0	Stage I	Stage II	Stage II
	Mild atrophy (score 1) (including incisura angularis)	Stage I	Stage I	Stage II	Stage III
	Moderate atrophy (score 2) (including incisura angularis)	Stage II	Stage II	Stage III	Stage IV
	Severe atrophy (score 3) (including incisura angularis)	Stage III	Stage III	Stage IV	Stage IV

The stage of gastritis results by combining the atrophy score values as obtained in antral and corpus biopsy samples[84,85].

Table 2 Studies that examined histological improvements with a follow-up duration of more than 5 years after Helicobacter pylori eradication[129-134]

Ref.	Authors	Year	Country	Number of patients	Study design	Observation period (yr)	Gastric atrophy		Intestinal metaplasia
							Antrum	Corpus	Antrum	Corpus
129	Forbes	1996	Australia	54	Prospective	7.1	No		No
130	Ito	2002	Japan	22	Prospective	5.0	Yes	Yes	Yes	Yes
131	Zhou	2003	China	552	RCT	5.0	No	No	Yes	No
132	Leung	2003	Hong Kong	435	RCT	5.0	ND		Yes
133	Vannella	2010	Italy	300	Observational	5.2	No	Yes	No	Yes
134	Kodama	2012	Japan	323	Prospective	10.0	Yes	Yes	No	Yes

RCT: Randomized control trial.