Brief Article
Copyright ©2013 Baishideng Publishing Group Co.
World J Gastroenterol. Dec 21, 2013; 19(47): 9049-9056
Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.9049
Table 1 Baseline characteristics of the study population n (%)
Crohn’s diseaseHealthy controls
(n = 42)(n = 20)
Age, mean ± SD (yr)38.7 ± 13.938.4 ± 8.7
Gender
Female20 (47.6)10 (50)
Male22 (52.4)10 (50)
Disease localization-
Ileum9 (21.4)
Colon2 (4.8)
Ileum + colon31 (73.8)
Medical treatment-
None9 (21.4)
Corticosteroids1 (2.4)
5-aminosalicylate8 (19)
Azathioprine33 (78.6)
Sulfasalazine1 (2.4)
More than one drug23 (54.8)
Median disease duration (yr) (IQR)1.2 (0.17)-
Prior intestinal resection18 (42.9)-
IQR: Interquartile range.
Table 2 Clinical and biochemical parameters of Crohn’s disease patients and healthy controls
Crohn’s disease (n = 42)Healthy controls (n = 20)P value1
CDAI87.0 (52-138)-
ESR (mm/h)35.5 (17.0-48)12.0 (10.5-14.5) < 0.001
CRP (mg/dL)0.6 (0.3-1.5)0.2 (0.1-0.3) < 0.001
Hb (g/dL)13.0 (11.8-13.9)14.0 (12.9-15)0.0063
WBC (× 103/mm3)7.7 (5.9-9.2)6.2 (5.3-7.9)0.0356
PLT (× 103/mm3)309.5 (245-359)240.0 (229.0-243.5)0.0001
Alb (g/L)3.9 (3.7-4.4)4.7 (4-5) < 0.001
IGFBP-5 (ng/mL)7.2 (5.5-11.3)11.3 (8.0-44.6)0.0019
1P value from Mann-Whitney test. Results are given as median. IQR: Interquartile range; CDAI: Crohn’s Disease Activity Index; ESR: Erythrocyte sedimentation rate; CRP: C-reactive protein; Hb: Hemoglobin; WBC: White blood cell count; PLT: Platelet count; Alb: Albumin; IGFBP-5, Insulin-like growth factor-binding protein 5.
Table 3 Characteristics of Crohn's disease patients with and without stricture formation n (%)
CD patients with stricture formation (n = 26)CD patients without stricture formation (n = 16)P value1
Age mean ± SD (yr) 41.4 (15.0)34.6 (11.0)0.124
Gender (F/M)11 (42.3)/15 (57.7)9 (56.3)/7 (43.8)0.527
Disease localization0.083
Ileum 3 (11.5)6 (37.5)
Colon 1 (3.9)1 (6.3)
Ileum + colon 22 (84.6)9 (56.3)
Disease duration (yr) 1.25 (0.25-12)1.2 (0-3.1)0.254
CDAI78.5 (50.0-122.0)112.0 (74.5-165.5)0.090
ESR (mm/h)36.5 (17.0-54.0)35.0 (21.0-39.5)0.660
CRP (mg/dL) 0.4 (0.3-1.2)1.0 (0.4-3.0)0.239
Hb (g/dL)13.0 (12.4-14.1)12.4 (11.5-13.7)0.468
WBC (× 103/mm3) 7.25 (5.5-9.6)8.8 (6.15-9.15)0.509
PLT (× 103/mm3) 309.5 (262-383)288.5 (234.0-334.0)0.399
Alb (g/L)  3.9 (3.6-4.4)4.1 (3.8-4.5)0.233
IGFBP-5 (ng/mL)6.9 (5.5-11.3)7.8 (5.3-10.1)0.815
1P values are from t test, Fisher’s exact and Mann-Whitney test statistics were appropriate. Results are given as median. IQR: Interquartile range; CDAI: Crohn’s Disease Activity Index; ESR: Erythrocyte sedimentation rate; CRP: C-reactive protein; Hb: Hemoglobin; WBC: White blood cell count; PLT: Platelet count; Alb: Albumin; IGFBP-5: Insulin-like growth factor-binding protein 5.
Table 4 Frequency of Insulin-like growth factor-binding protein 5 positive samples and the median intensity score of IGFBP-5 immunostaining (scores 0 to 3) in Crohn’s disease patients with and without stricture formation n (%)
CD patients with stricture formation (n = 26)CD patients without stricture formation (n = 16)P value1
Number of IGFBP-5 positive samples16 (61.5)8 (50)0.463
Median intensity score of IGFBP-5 immunostaining10.50.405
1P values are from Fisher’s exact and Mann-Whitney test statistics were appropriate. IGFBP-5: Insulin-like growth factor -binding protein 5; CD: Crohn's disease.