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World J Gastroenterol. Dec 21, 2013; 19(47): 9049-9056
Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.9049
Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.9049
Serum concentrations of insulin-like growth factor-binding protein 5 in Crohn’s disease
Gupse Adali, Elif Yorulmaz, Celal Ulasoglu, Yasar Colak, Ilyas Tuncer, Department of Gastroenterology, Goztepe Training and Research Hospital, Istanbul Medeniyet University, Doktor Erkin Caddesi Kadikoy, Istanbul 34730, Turkey
Seyma Ozkanli, Department of Pathology, Goztepe Training and Research Hospital, Istanbul Medeniyet University, Doktor Erkin Caddesi Kadikoy, Istanbul 34730, Turkey
Baris Bayraktar, Department of General Surgery, Goztepe Training and Research Hospital, Istanbul Medeniyet University, Doktor Erkin Caddesi Kadikoy, Istanbul 34730, Turkey
Alev Orhun, Department of Biochemistry, Goztepe Training and Research Hospital, Istanbul Medeniyet University, Doktor Erkin Caddesi Kadikoy, Istanbul 34730, Turkey
Author contributions: Adali G designed the research, performed the statistical analysis and wrote the manuscript; Ozkanli S and Orhun A performed the experiments; Yorulmaz E and Bayraktar B provided the collection of all the human material; Colak Y, Ulasoglu C and Tuncer I contributed to writing the manuscript.
Correspondence to: Gupse Adali, MD, Department of Gastroenterology, Goztepe Training and Research Hospital, Istanbul Medeniyet University, Doktor Erkin Caddesi Kadikoy, Istanbul 34730, Turkey. gupseadali@gmail.com
Telephone: +90-216-5666600 Fax: +90-216-5666628
Received: July 8, 2013
Revised: September 1, 2013
Accepted: September 15, 2013
Published online: December 21, 2013
Processing time: 198 Days and 10.9 Hours
Revised: September 1, 2013
Accepted: September 15, 2013
Published online: December 21, 2013
Processing time: 198 Days and 10.9 Hours
Core Tip
Core tip: Previous studies have suggested that insulin-like growth factors are important for the growth and development of visceral smooth muscle. In particular, increased insulin-like growth factor-binding protein 5 expression has been described in inflamed and fibrotic intestinal tissue. In this study, we aim to investigate the possible role of insulin-like growth factor-binding protein 5 in Crohn’s disease with stricture involvement. Crohn’s disease patients had lower serum levels of IGFBP-5 compared to healthy controls. The results of the study suggest that additional research is necessary to explain the low circulating levels of IGFBP-5 in Crohn’s disease patients.