Perirenal space blocking restores gastrointestinal function in patients with severe acute pancreatitis

Table 1 The modified gastrointestinal failure score

Item	Points
	0	1	2
Number of FI symptoms	None	1–2	≥ 3
IAP (mmHg)	12	12–20	> 20 or ACS
Endotoxin concentration (pg/mL)	< 10	10–50	> 50
Computed tomography findings	None	Bowel wall thickening or intestinal extension	Bowel wall thickening and intestinal extension

FI: Food intolerance; IAP: Intra-abdominal pressure; ACS: Abdominal compartment syndrome.

Table 2 Patient characteristics upon admission n (%)

	PSB group	NPSB group	P value
	(n = 20)	(n = 20)
Age (yr)	43 (34.5-55)	45 (35-60)	0.589
Sex (male: female)	11:9	12:8	0.749
Etiology
Biliary origin	10 (50)	11 (55)	0.752
Hyperlipidemia	7 (35)	6 (30)	0.736
Alcohol abuse	2 (10)	1 (5)	0.548
Idiopathic	1 (5)	2 (10)	0.548
BMI	24.6 (23.5-26.8)	25.8 (23.9-28.8)	0.158
APACHEII score	9.5 (8.5-11)	10 (8-11.5)	0.994
CRP (mg/L)	203.5 (188-253)	195 (161-247.5)	0.214
Pain > 77 mm (VAS)	13	15	0.654

PSB: Perirenal space blocking; NPSB: No perirenal space blocking; BMI: Body mass index; VAS: Visual analogue scale; CRP: C-reactive protein.

Table 3 Pain intensity between two groups

	Pain severity:	Pain severity: Change from baseline (∆VAS)
	Baseline (VAS)	At 24 h	At 48 h	At 72 h
PSB group (n = 20)	78	-53	-67	-76
NPSB group (n = 20)	77	-23	-46	-49
P value	1.000	0.005	0.018	0.025

PSB: Perirenal space blocking; NPSB: No perirenal space blocking; VAS: Visual analogue scale.

Table 4 Modified gastrointestinal failure score variables between two groups

	Before PSB	Hospital day
	performed	1 d	3 d	7 d	10 d
PSB group (n = 20)	4.56	2.6	2.12	1.43	1.000
NPSB group (n = 20)	4.34	3.98	3.56	2.58	2.13
P value	1.000	0.042	0.025	0.031	0.012

PSB: Perirenal space blocking; NPSB: No perirenal space blocking.

Table 5 Clinical outcome variables n (%)

	NPSB group	PSB group	P value
	(n = 20)	(n = 20)
Hospital mortality	6 (30)	1 (5)	0.037
ICU stay (d)	12 (8-21)	9 (5-14)	0.033
Pancreatic infection	8 (40)	2 (10)	0.028
MODS	9 (45)	3 (15)	0.038
SIRS	14 (70)	7 (35)	0.027
Surgical operation	4 (20)	2 (10)	0.376

ICU: Intensive care unit; MODS: Multiple organ dysfunction syndrome; SIRS: Systemic inflammatory response syndrome; PSB: Perirenal space blocking; NPSB: No perirenal space blocking.