Chen SB, Weng HR, Wang G, Yang JS, Yang WP, Liu DT, Chen YP, Zhang H. Primary adenosquamous carcinoma of the esophagus. World J Gastroenterol 2013; 19(45): 8382-8390 [PMID: 24363531 DOI: 10.3748/wjg.v19.i45.8382]
Corresponding Author of This Article
Yu-Ping Chen, MD, Professor, Department of Thoracic Surgery, Cancer Hospital of Shantou University Medical College, 7 Raoping Road, Shantou 515031, Guangdong Province, China. stchenyp@hotmail.com
Research Domain of This Article
Oncology
Article-Type of This Article
Brief Article
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Dec 7, 2013; 19(45): 8382-8390 Published online Dec 7, 2013. doi: 10.3748/wjg.v19.i45.8382
Table 1 Clinopathologic features of the 37 patients with esophageal adenosquamous carcinoma
Gender
Age (yr)
Location
Length (cm)
Macroscopic tumor type
pT
pN
Operation
Treatment
Result
Last follow up (mo)
M
40
Lt
7
Medullary
4a
1
Radical
S + R
D
4
M
51
Mt
7
Medullary
3
2
Radical
S
D
19
F
74
Mt
8
Polypoid
4a
1
Radical
S
A
158
M
47
Mt
5
Medullary
3
1
Radical
S + R
A
114
M
64
Mt
7
Medullary
4a
0
Radical
S
D
2
F
51
Mt
3
Medullary
3
0
Radical
S
D
74
M
61
Ut
4
Medullary
1b
0
Radical
S
D
45
M
42
Ut
4
Sclerotic
4b
0
Palliative
S
D
20
M
50
Mt
3
Medullary
3
0
Radical
S
D
42
M
56
Mt
6
Ulcerative
3
0
Radical
S
D
21
M
60
Mt
3
Sclerotic
3
0
Radical
S + R
D1
140
M
63
Lt
4
Medullary
3
1
Radical
S
D
14
M
65
Mt
4
Sclerotic
3
0
Radical
S
D
26
M
67
Mt
10
Intraluminal
2
0
Radical
S
D
1
M
72
Mt
4
Medullary
3
1
Radical
S
D
11
M
56
Mt
4
Medullary
3
1
Radical
S
D
15
M
78
Mt
4
Medullary
2
1
Radical
S
D
12
F
66
Lt
2
Ulcerative
2
1
Radical
S + R
D
28
M
50
Mt
7
Medullary
4a
2
Radical
S + R
D
11
M
40
Mt
5
Medullary
1b
0
Radical
S
D
30
M
53
Mt
6
Medullary
3
1
Radical
S
D
25
F
54
Mt
4
Medullary
3
0
Radical
S
D
5
M
62
Mt
4
Medullary
3
3
Palliative
S + C
D
5
M
63
Mt
4
Medullary
3
0
Radical
S
A
85
M
63
Ut
6
Medullary
3
0
Radical
S
D
19
M
41
Mt
6
Medullary
3
1
Radical
S + R
A
80
M
47
Mt
6
Medullary
3
0
Radical
S
D
9
M
57
Mt
3
Polypoid
2
0
Radical
S
A
60
M
53
Mt
6
Medullary
3
3
Radical
S
D
10
M
65
Mt
3
Medullary
1b
0
Radical
S
D
33
M
56
Mt
3
Medullary
3
1
Radical
S + R
D
32
F
45
Mt
3
Medullary
3
0
Radical
S + R
L
16
M
63
Mt
7
Medullary
3
1
Radical
S + R
A
34
M
63
Lt
2
Medullary
1b
3
Radical
S
D
6
M
65
Mt
5
Medullary
3
1
Radical
S + R
D
20
F
73
Mt
5
Medullary
3
1
Radical
S
A
11
M
73
Lt
10
Medullary
4a
2
Palliative
S
D
2
Table 2 Univariate analysis of the prognosis of the 37 patients with esophageal adenosquamous carcinoma
Number of patients
Survival rate
MST (mo, 95%CI)
P value
1-yr
3-yr
5-yr
Gender
0.302
Male
31
64.5%
25.8%
18.4%
20.0 (13.5-26.5)
Female
6
83.3%
55.6%
55.6%
74.0 (0.0-149.4)
Age (yr)
0.448
≤ 60
19
73.7%
34.2%
28.5%
25.0 (11.6-38.4)
> 60
18
60.6%
24.2%
16.2%
19.0 (8.6-29.4)
Location
0.031
Ut
3
100.0%
33.3%
0.0%
20.0 (18.4-21.6)
Mt
29
68.8%
34.5%
30.2%
25.0 (12.8-37.2)
Lt
5
40.0%
0.0%
0.0%
6.0 (1.7-10.3)
Length
0.630
≤ 4 cm
19
73.7%
34.4%
23.0%
28.0 (12.0-44.0)
> 4 cm
18
61.1%
24.4%
24.4%
19.0 (7.4-30.6)
Macroscopic tumor type
< 0.001
Medullary
29
61.9%
27.3%
18.2%
19.0 (11.7-26.3)
Intraluminal
1
0.0%
0.0%
0.0%
1.0
Polyploid
2
100.0%
100.0%
100.0%
-
Ulcerative
2
100.0%
0.0%
0.0%
21.0
Sclerotic
3
100.0%
33.3%
33.3%
26.0 (16.4-35.6)
pT category
0.573
pT1
4
75.0%
25.0%
0.0%
30.0 (3.5-56.5)
pT2
4
50.0%
25.0%
25.0%
12.0 (0.0-38.5)
pT3
23
78.3%
34.5%
28.8%
21.0 (12.4-29.6)
pT4
6
33.3%
16.7%
16.7%
4.0 (0.0-14.8)
pN category
0.002
pN0
17
76.5%
38.2%
25.5%
30.0 (12.8-47.2)
pN1
14
77.9%
31.2%
31.2%
25.0 (9.9-40.1)
pN2
3
33.3%
0.0%
0.0%
11.0 (0.0-25.4)
pN3
3
0.0%
0.0%
0.0%
6.0 (4.4-7.6)
Adjuvant radiotherapy
0.066
No
27
62.7%
23.5%
15.7%
19.0 (11.7-26.3)
Yes
10
80.0%
45.7%
45.7%
32.0
Operation
0.025
Radical
34
70.5%
32.2%
25.0%
25.0 (15.4-34.6)
Palliative
3
33.3%
0.0%
0.0%
5.0 (0.2-9.8)
Table 3 Multivariate Cox regression analysis for the prognosis of the 37 patients with esophageal adenosquamous carcinoma
Prognostic factor
Hazard ratio
95%CI
P value
Location
2.177
0.797-5.951
0.129
Macroscopic tumor type
1.002
0.633-1.585
0.995
pN category
1.656
0.956-2.871
0.072
Adjuvant radiotherapy
0.317
0.114-0.885
0.028
Operation
3.718
0.782-17.679
0.099
Table 4 Comparison of clinicopathological variables between patients with esophageal adenosquamous carcinoma and those with squamous cell carcinoma
Variable
ASC
SCC
P value
Well differentiated (n = 1011)
Moderately differentiated (n = 2007)
Poorly differentiated (n = 421)
Total (n = 3439)
Gender
0.191
Male
31
748
1473
313
2534
Female
6
263
534
108
905
Age (yr)
0.056
≤ 60
19
672
1347
270
2289
> 60
18
339
660
151
1150
Location
0.647
Ut
3
124
284
54
462
Mt
29
746
1426
303
2475
Lt
5
141
297
64
502
Tumor length
0.182
≤ 4 cm
19
397
799
191
1387
> 4 cm
18
614
1208
230
2052
pT category
0.409
pTis
0
10
17
5
32
pT1a
0
18
35
10
63
pT1b
4
39
88
22
149
pT2
4
202
350
80
632
pT3
23
562
1135
232
1929
pT4a
5
139
278
68
485
pT4b
1
41
84
24
149
pN category
0.187
pN0
17
587
1049
212
1848
pN1
14
235
530
110
875
pN2
3
151
328
69
548
pN3
3
38
100
30
168
Adjuvant radiotherapy
1.000
No
27
729
1465
292
2486
Yes
10
282
542
129
953
Operation
0.755
Radical
34
945
1851
385
3181
Palliative
3
66
156
36
258
Table 5 Comparison of prognosis between patients with adenosquamous carcinoma and those with squamous cell carcinoma
Cases
1-yr OS
3-yr OS
5-yr OS
MST (mo, 95%CI)
Well differentiated SCC
1011
87.5%
67.1%
58.9%
148.0
Moderately differentiated SCC
2007
81.0%
51.5%
42.5%
39.0 (34.7-43.3)
Poorly differentiated SCC
421
72.6%
37.3%
27.4%
22.0 (18.3-25.7)
Total SCC
3439
81.8%
54.3%
45.6%
46.0 (40.8-51.2)
ASC
37
67.5%
29.4%
22.9%
21.0 (12.6-29.4)
Citation: Chen SB, Weng HR, Wang G, Yang JS, Yang WP, Liu DT, Chen YP, Zhang H. Primary adenosquamous carcinoma of the esophagus. World J Gastroenterol 2013; 19(45): 8382-8390