Association of visceral obesity and early colorectal neoplasia

Table 1 Comparison of the baseline characteristics of the colorectal cancer, adenoma, and control groups n (%)

Characteristics	Control (n = 557)	Adenoma (n = 554)	Cancer (n = 153)	P value
Age (yr)	59.1 ± 8.7	59.1 ± 8.2	60.3 ± 9.1	0.278
Male	370 (66.4)	372 (67.1)	100 (65.4)	0.910
Alcohol consumption	77 (13.8)	86 (15.5)	31 (20.3)	0.146
Current smoking	86 (15.4)	106 (19.1)	28 (18.3)	0.255
Hypertension	195 (35.0)	217 (39.2)	63 (41.2)	0.222
Diabetes	70 (12.6)	70 (12.6)	19 (12.4)	0.997
Body mass index (kg/m2)	23.80 ± 2.48	24.34 ± 2.56	24.25 ± 2.51	0.001
≤ 22.9	194 (34.8)	150 (27.1)	46 (30.1)	0.011
23.0-24.9	197 (35.4)	188 (33.9)	51 (33.3)
25.0-29.9	161 (28.9)	202 (36.5)	55 (35.9)
≥ 30.0	5 (0.9)	14 (2.5)	1 (0.7)
Total cholesterol (mg/dL)	197.7 ± 35.5	193.1 ± 35.4	179.9 ± 45.5	< 0.001
Fasting glucose (mg/dL)	100.7 ± 21.2	100.7 ± 20.0	107.3 ± 26.4	0.002
Total adipose tissue area (cm2)	262.4 ± 81.3	281.3 ± 90.1	264.1 ± 86.0	0.001
Visceral adipose tissue area (cm2)	120.6 ± 49.0	130.6 ± 58.4	117.6 ± 51.6	0.002
Subcutaneous adipose tissue area (cm2)	141.9 ± 55.0	150.7 ± 59.8	146.5 ± 56.6	0.040

Results are expressed as mean ± SD.

Table 2 Body measure index, adipose tissue area and the risk of colorectal cancer vs control

	Univariate		Multivariate 11		Multivariate 22
	OR (95%CI)	P value	OR (95%CI)	P value	OR (95%CI)	P value
BMI
Quartile I	1	0.0213	1	0.0253
Quartile II	0.82 (0.49-1.40)	0.471	0.81 (0.48-1.38)	0.446
Quartile III	1.33 (0.81-2.20)	0.262	1.32 (0.80-2.19)	0.279
Quartile IV	1.61 (0.97-2.66)	0.066	1.58 (0.95-2.63)	0.077
VAT
Quartile I	1	0.4783	1	0.5013	1	0.3783
Quartile II	0.80 (0.49-1.31)	0.376	0.79 (0.48-1.29)	0.341	0.73 (0.43-1.23)	0.235
Quartile III	0.65 (0.40-1.07)	0.089	0.65 (0.40-1.07)	0.089	0.59 (0.35-1.02)	0.057
Quartile IV	0.92 (0.56-1.53)	0.758	0.93 (0.56-1.54)	0.776	0.82 (0.47-1.46)	0.507
SAT
Quartile I	1	0.7163	1	0.7703	1	0.5223
Quartile II	1.10 (0.67-1.82)	0.708	1.10 (0.66-1.82)	0.726	1.25 (0.73-2.13)	0.426
Quartile III	1.10 (0.62-1.68)	0.940	1.00 (0.60-1.66)	0.993	1.15 (0.66-1.99)	0.623
Quartile IV	1.14 (0.68-1.89)	0.625	1.12 (0.67-1.87)	0.664	1.31 (0.73-2.34)	0.362

¹Multivariate model 1 was adjusted for current smoking status, and alcohol consumption;

²Multivariate model 2 was adjusted for subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT), in addition. Since body mass index (BMI) showed co-linearity to adipose tissue amount, it was not included in the analysis;

³P value for test of trend of odds.

Table 3 Body measure index, adipose tissue area and the risk of colorectal cancer vs colorectal adenoma

	Univariate		Multivariate 11		Multivariate 22
	OR (95%CI)	P value	OR (95%CI)	P value	OR (95%CI)	P value
BMI
Quartile I	1	0.9373	1	0.8873
Quartile II	0.87 (0.51-1.48)	0.600	0.86 (0.50-1.48)	0.595
Quartile III	0.96 (0.58-1.58)	0.875	0.96 (0.58-1.58)	0.857
Quartile IV	0.95 (0.58-1.55)	0.824	0.93 (0.57-1.53)	0.777
VAT
Quartile I	1	0.0323	1	0.0243	1	0.0283
Quartile II	0.74 (0.45-1.21)	0.227	0.74 (0.45-1.20)	0.224	0.70 (0.42-1.18)	0.182
Quartile III	0.71 (0.43-1.17)	0.182	0.68 (0.41-1.13)	0.141	0.65 (0.38-1.12)	0.118
Quartile IV	0.57 (0.35-0.94)	0.028	0.56 (0.34-0.92)	0.023	0.53 (0.31-0.92)	0.024
SAT
Quartile I	1	0.5503	1	0.5563	1	0.7293
Quartile II	0.90 (0.55-1.49)	0.686	0.91 (0.55-1.50)	0.697	1.08 (0.63-1.83)	0.786
Quartile III	1.03 (0.62-1.71)	0.898	1.02 (0.62-1.70)	0.933	1.26 (0.73-2.17)	0.407
Quartile IV	0.82 (0.49-1.35)	0.427	0.82 (0.50-1.36)	0.443	1.09 (0.62-1.91)	0.362

¹Multivariate model 1 was adjusted for current smoking status, and alcohol consumption;

²Multivariate model 2 was adjusted for subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT), in addition. Since body mass index (BMI) showed co-linearity to adipose tissue amount, it was not included in the analysis;

³P value for test of trend of odds.