Overexpression of nuclear β-catenin in rectal adenocarcinoma is associated with radioresistance

Table 1 Correlation of nuclear β-catenin expression in rectal adenocarcinoma with clinicopathologic characteristics

Characteristics	n	Nuclearβ-catenin expression		P value1
		≤50%	> 50%
Gender
Male	108	54	54	0.312
Female	28	11	17
Age (yr)
≤ 55	19	11	8	0.342
> 55	117	54	63
Tumor size (cm)
≤ 5	78	38	40	0.802
> 5	58	27	31
Tumor cell differentiation
Well/moderately differentiated	98	53	45	0.018
Poorly differentiated	38	12	26
Tumor invasion depth
T1/T2	23	15	8	0.066
T3/T4	113	50	63
Lymph node metastasis
N1	74	42	32	0.022
N2	62	23	39
TRG
TRG0-2	118	50	68	< 0.001
TRG3-4	18	15	3

¹Value is the result of χ² test in the same factor, and P < 0.05 is considered significant statistically. TRG: Tumor regression grading.

Table 2 Univariate and multivariate regression analyses of the association of clinical features with radiotherapy response of rectal adenocarcinoma n (%)

Clinicopathological factors	Univariate analysis		Multivariate analysis
	Good response1	P value	OR	P value
Gender
Male	15 (13.8)	0.697		NS
Female	3 (10.7)
Age (yr)
≤ 55	5 (26.3)	0.129		NS
> 55	13 (11.1)
Tumor size (cm)
≤ 5	16 (20.5)	< 0.001	5.058	< 0.001
> 5	2 (3.5)
Tumor cell differentiation
Well/moderately differentiated	4 (4.1)	< 0.001	4.692	< 0.001
Poorly differentiated	14 (36.8)
Tumor invasion depth
T1/T2	7 (30.4)	0.027	1.143	0.053
T3/T4	11 (9.7)
Nuclear β-catenin expression
≤ 50%	15 (23.1)	< 0.001	6.375	< 0.001
> 50%	3 (4.2)

¹Tumor regression grading ≥ 3. NS: Not selected.

Table 3 Predictive value of nuclear β-catenin as a marker of radioresistance in 136 patientsof rectal adenocarcinoma

Nuclearβ-catenin expression	Good response	Poor response
≤ 50%	15%	50%
> 50%	3%	68%
Accuracy		83%
Sensitivity		65%
Specificity	88%
Positive predictive value		79%
Negative predictive value	48%