Antiviral therapy delays esophageal variceal bleeding in hepatitis B virus-related cirrhosis

doi:10.3748/wjg.v19.i40.6849

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Oct 28, 2013 (publication date) through Nov 3, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 28, 2013; 19(40): 6849-6856
Published online Oct 28, 2013. doi: 10.3748/wjg.v19.i40.6849

Table 1 Demography of the patients (mean ± SD)

	Non- antiviral (n = 38)	Antiviral (n = 79)	P value	Normal range
Gender (male/female)	30/8	62/17	1.000
Age (yr)	51.8 ± 10.3	50.4 ± 8.8	0.443
Median Child-Pugh score	8	8	0.887
Previous grade of EV (0/1/2/3)	21/0/6/11	41/4/18/16	0.330
Previous copies of HBVDNA (log10)	4.2 ± 1.1	4.6 ± 2.5	0.176	(-)
Previous hepatitis B e antigen (+/-)	24/14	46/33	0.689	(-)
Previous diameter of portal vein (mm)	11.8 ± 2.1	12.6 ± 2.2	0.392	< 10
Previous splenic section area (cm²)	35.3 ± 9.5	37.4 ± 13.2	0.384	< 20
GPT (IU/L)	49.7 ± 21.1	53.3 ± 64.9	0.315	5-40
GOT (IU/L)	48.1 ± 32.8	57.9 ± 56.2	0.231	5-40
TB (mmol/L)	26.7 ± 14.6	25.1 ± 15.5	0.635	3.4-17.1
ALB (g/L)	24.7 ± 4.9	25.4 ± 5.0	0.667	35-50
PT (s)	14.9 ± 2.5	16.5 ± 7.9	0.236	< 12
PLT (10¹²/L)	83.1 ± 41.8	78.7 ± 41.9	0.600	100-300
Endoscopic eradication (yes/no)	17/21	37/42	0.846
Propranolol (yes/no)	30/8	65/14	0.801

EV: Esophageal varices; HBV DNA: Hepatitis B virus DNA; GPT: Glutamic-pyruvic transaminase; GOT: Glutamic-oxaloacetic transaminase; TB: Total bilirubin; ALB: Serum albumin; PT: Prothrombin time; PLT: Platelet count.

Table 2 Laboratory examination results, portal diameter and splenic area in antiviral and non-antiviral groups during the study (mean ± SD)

	Non-antiviral	Antiviral	P value
	(n = 38)	(n = 79)
GPT (IU/L)	19.2 ± 53.1	-28.6 ± 58.8	< 0.001
GOT (IU/L)	19.9 ± 52.8	-34.9 ± 86.2	0.001
TB (mmol/L)	3.9 ± 9.6	-3.8 ± 9.5	0.009
ALB (g/L)	-2.8 ± 5.5	1.2 ± 6.1	0.003
PT (s)	1.4 ± 2.2	-0.2 ± 2.1	0.001
PLT (10¹²/L)	-18.9 ± 28.8	-10.3 ± 16.9	0.029
Diameter of portal vein (mm)	1.0 ± 0.9	0.2 ± 0.8	< 0.001
Splenic section area (cm²)	8.6 ± 7.2	3.6 ± 9.8	0.012

GPT: Glutamic-pyruvic transaminase; GOT: Glutamic-oxaloacetic transaminase; TB: Total bilirubin; ALB: Serum albumin; PT: Prothrombin time; PLT: Platelet count.

Table 3 Increase in score of varices/year in antiviral and non-antiviral therapy

	Non-antiviral	Antiviral	P value
All the cases (n = 117)	1.7 ± 1.2	1.0 ± 1.3	0.003
Endoscopic eradication (n = 63)	1.8 ± 1.5	1.1 ± 1.6	0.098
No endoscopic intervention (n = 54)	1.6 ± 0.7	0.8 ± 0.9	0.003

Citation: Li CZ, Cheng LF, Li QS, Wang ZQ, Yan JH. Antiviral therapy delays esophageal variceal bleeding in hepatitis B virus-related cirrhosis. World J Gastroenterol 2013; 19(40): 6849-6856
URL: https://www.wjgnet.com/1007-9327/full/v19/i40/6849.htm
DOI: https://dx.doi.org/10.3748/wjg.v19.i40.6849