Meta-Analysis
Copyright ©2013 Baishideng Publishing Group Co.
World J Gastroenterol. Oct 21, 2013; 19(39): 6665-6678
Published online Oct 21, 2013. doi: 10.3748/wjg.v19.i39.6665
Table 1 Characteristics of included randomized controlled trials
TrialSample size (n)
mean age (yr)
Regimen
Duration (wk)Observation time (wk)Outcome parametersJadad scores
ETVLAMETVLAMETVLAM
Feng et al[8]2225--0.5 mg/d100 mg/d484, 12, 24, 36, 48ACDGI3
Yang et al[9]303047.5 ± 9.70.5 mg/d100 mg/d484, 8, 12, 24, 48ABCI3
Shen[10]404046.548.50.5 mg/d100 mg/d4848BDEFIJ3
Huang et al[11]222248.247.50.5 mg/d100 mg/d5252BDEFGHIJ3
Chen et al[12]232448.50.5 mg/d100 mg/d4824, 48ACJ3
Li et al[13]404051.00.5 mg/d100 mg/d4812, 24, 48ACDEFHI2
Shao et al[14]292843.1 ± 10.26244.11 ± 10.3220.5 mg/d100 mg/d9612, 24, 36, 48, 60, 72, 84, 96AHIJ3
Kong[15]242447.50.5 mg/d100 mg/d4848BDEFGH2
Hyun et al[16]454154 ± 9.453.7 ± 12.10.5 mg/d100 mg/d4812, 24, 36, 48ABCHIJ3
Wang et al[17]666452.3 ± 15.850.8 ± 15.40.5 mg/d100 mg/d4812, 24, 36, 48ABCGHI2
Yang et al[18]324247.8 ± 10.20.5 mg/d100 mg/d4812, 24, 36, 48ACDEFI3
Zhou et al[19]404046 ± 140.5 mg/d100 mg/d4812, 24, 48BDH3
Liu et al[20]303046.04 ± 10.7945.75 ± 10.260.5 mg/d100 mg/d4848B3
Table 2 Sensitivity analysis
IndexTotal HBV DNA undetectability
RRP value
Removing the inferior quality trials[13,15,17]1.26 (1.15, 1.39)< 0.0001
Using random-effect model1.24 (1.16, 1.33)< 0.00001
Using fixed-effect model1.29 (1.22, 1.37)< 0.00001