Proton pump inhibitor resistance, the real challenge in gastro-esophageal reflux disease

doi:10.3748/wjg.v19.i39.6529

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Oct 21, 2013 (publication date) through Dec 19, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 21, 2013; 19(39): 6529-6535
Published online Oct 21, 2013. doi: 10.3748/wjg.v19.i39.6529

Table 1 Principal mechanisms and factors involved in proton pump inhibitor resistance

Adherence to PPI therapy

Compliance

Dosing, time

Reflux pattern

Weakly acidic reflux

Proximal reflux

Mixed reflux

Residual acid refluxes

Esophageal hypersensitivity

Other mechanisms

Reduced PPI bioavailability

Increased PPI metabolism

Mutations cyt. p450

PPI: Proton pump inhibitor.

Citation: Cicala M, Emerenziani S, Guarino MPL, Ribolsi M. Proton pump inhibitor resistance, the real challenge in gastro-esophageal reflux disease. World J Gastroenterol 2013; 19(39): 6529-6535
URL: https://www.wjgnet.com/1007-9327/full/v19/i39/6529.htm
DOI: https://dx.doi.org/10.3748/wjg.v19.i39.6529