Overexpression of insulin-like growth factor-I receptor as a pertinent biomarker for hepatocytes malignant transformation

doi:10.3748/wjg.v19.i36.6084

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Sep 28, 2013 (publication date) through May 8, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 28, 2013; 19(36): 6084-6092
Published online Sep 28, 2013. doi: 10.3748/wjg.v19.i36.6084

Table 1 Histopathological changes of liver in hepatocarcinogenesis (hematoxylin and eosin staining)

Group	n	Histopathological changes in rat liver tissue
Group	n	Control	Degeneration	Precancerosis	HCC
Control	12	12	0	0	0
Experimental
2^nd wk	6	0	6	0	0
4^th wk	6	0	6	0	0
6^th wk	6	0	5	1	0
8^th wk	6	0	1	4	1
10^th wk	6	0	0	3	3
12^th wk	6	0	0	1	5
Total	48	12	18	9	9

HCC: Hepatocellular carcinoma.

Table 2 Total RNA and insulin-like growth factor-I receptor mRNA expression in hepatocarcinogenesis n (%)

Group	n	Total RNA level			IGF-IR mRNA
Group	n	(μg/mg wet liver)	q	P value	Positive	P value
Control	12	1.58 ± 0.94			0 (0.0)
Degeneration	18	1.91 ± 0.60¹	1.177	0.249	11 (61.1)¹	< 0.001
Precancerosis	9	2.00 ± 0.21¹	1.308	0.206	9 (100)¹	< 0.001
HCC	9	2.86 ± 0.60¹	3.843	0.001	9 (100)¹	< 0.001

¹Compared with the control group. IGF-IR: Insulin-like growth factor-I receptor; HCC: Hepatocellular carcinoma.

Table 3 Dynamic alteration of liver insulin-like growth factor-I receptor expression in hepatocarcinogenesis n (%)

Group	n	Positive	P value	IGF-IR intensity				Nemenyi test	P value
Group	n	Positive	P value	-	+	++	+++	Nemenyi test	P value
Control	12	0 (0.0)		12	0	0	0
Degeneration	18	9 (50.0)¹	0.004	9	4	4	1	13.716¹	< 0.050
Precancerosis	9	8 (88.9)¹	< 0.001	1	3	2	3	16.229¹	< 0.001
HCC	9	9 (100)¹	< 0.001	0	1	5	3	16.299¹	< 0.001

¹Compared with the control group by the Kruskal-Wallis test (HC = 25.5149, P < 0.001). IGF-IR: Insulin-like growth factor-I receptor; HCC: Hepatocellular carcinoma.

Table 4 Insulin-like growth factor-I level in rat livers or sera during malignant transformation of hepatocytes

Group	n	Serum IGF-IR			Liver IGF-IR
Group	n	nmol/mL	q	P value	nmol/mg wet liver	q	P value
Control	12	1.03 ± 0.47			0.43 ± 0.17
Degeneration	18	1.51 ± 0.46¹	1.486	0.318	0.55 ± 0.20¹	0.456	0.812
Precancerosis	9	1.92 ± 0.29¹	4.116	0.003	0.66 ± 0.14¹	0.578	0.748
HCC	9	2.43 ± 0.57¹	7.674	< 0.001	0.96 ± 0.09¹	6.357	< 0.001

¹Compared with the control group. IGF-IR: Insulin-like growth factor-I receptor; HCC: Hepatocellular carcinoma.

Citation: Yan XD, Yao M, Wang L, Zhang HJ, Yan MJ, Gu X, Shi Y, Chen J, Dong ZZ, Yao DF. Overexpression of insulin-like growth factor-I receptor as a pertinent biomarker for hepatocytes malignant transformation. World J Gastroenterol 2013; 19(36): 6084-6092
URL: https://www.wjgnet.com/1007-9327/full/v19/i36/6084.htm
DOI: https://dx.doi.org/10.3748/wjg.v19.i36.6084