Glycyrrhizinate reduces portal hypertension in isolated perfused rat livers with chronic hepatitis

Table 1 Exudations and organ indexes (mean ± SE, n = 8)

Groups	Exudations [g/(100g)]		Organ indexes [g/(100g)]
	Water	Dried mass	Liver	Spleen	Kidneys
d00	0.223 ± 0.091	0.490 ± 0.260	2.801 ± 0.347	0.163 ± 0.040	0.731 ± 0.096
d28	0.372 ± 0.127b	1.250 ± 0.210b	5.936 ± 1.081b	0.236 ± 0.037b	0.854 ± 0.095a
d56	0.791 ± 0.134bd	1.540 ± 0.150bd	4.472 ± 0.909bd	0.292 ± 0.103b	0.861 ± 0.117a
d84	2.267 ± 0.732bdf	3.590 ± 1.610bdf	3.037 ± 0.349df	0.409 ± 0.095bde	1.071 ± 0.117bdf

^aP < 0.05,

^bP < 0.01 vs d₀₀;

^dP < 0.01 vs d₂₈;

^eP < 0.05,

^fP < 0.01 vs d₅₆.

Table 2 Changed levels of serum biomarkers (mean ± SE, n = 8)

Groups	ALT (IU/L)	AST (IU/L)	ALP (IU/L)	TP (g/L)	Alb (g/L)
d00	49.63 ± 14.03	124.13 ± 20.20	72.88 ± 14.58	63.63 ± 4.26	33.12 ± 1.97
d28	237.13 ± 107.91b	503.25 ± 235.12b	318.75 ± 147.81b	56.84 ± 5.43b	25.93 ± 3.16b
d56	160.25 ± 42.39bc	411.63 ± 143.51b	363.50 ± 170.36b	54.91 ± 5.27b	24.13 ± 4.25b
d84	230.00 ± 58.58bf	475.50 ± 201.02b	303.00 ± 225.94b	58.36 ± 7.92	26.98 ± 6.86a

^aP < 0.05,

^bP < 0.01 vs d₀₀;

^cP < 0.05 vs d₂₈;

^fP < 0.01 vs d₅₆.ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; ALP: Alkaline phosphatase; TP: Total protein; Alb: Albumin.

Table 3 Pathological changes and inducible nitric oxide synthase levels (mean ± SE, n = 8)

Groups	PP (mmHg)	Lobule	Collagen	iNOS-OD/V
d00	6.648 ± 2.235	0.564% ± 0.022%	0.048% ± 0.013%	0.165 ± 0.011
d28	9.225 ± 2.114b	0.511% ± 0.031%b	0.248% ± 0.120%b	0.197 ± 0.005b
d56	24.724 ± 3.368bd	0.230% ± 0.024%bd	1.974% ± 0.637%bd	0.132 ± 0.010bd
d84	26.752 ± 3.263bdf	0.134% ± 0.009%bdf	5.925% ± 1.761%bdf	0.236 ± 0.040bdf

^bP < 0.01 vs d₀₀;

^dP < 0.01 vs d₂₈;

^fP < 0.01 vs d₅₆. PP: Portal pressure; iNOS: Inducible nitric oxide synthase.