Disparities of conjugating protective enzyme activities in the colon of patients with adenomas and carcinomas

Table 1 Patient characteristics n (%)

Characteristics	Colorectal cancer (n = 20)	Adenomas (n = 28)	P-value
Sex			0.0011
Male	9 (45)	24 (86)
Female	11 (55)	4 (14)
Age, yr, mean (min-max)	68.4	68.4	NS2
	(39-86)	(51-88)
Alcohol			0.0211
Yes	3 (16)	15 (54)
No	17 (84)	13 (46)
Smoking			NS1
Yes	3 (16)	2 (16)
No	17 (84)	26 (84)
Aspirin			NS1
Yes	2 (10)	5 (18)
No	18 (90)	23 (82)
NSAIDs	0 (0)	1 (3)	NS1
Yes	20 (100)	27 (97)
No
BMI (kg/m2)	25.1	25.6	NS2

Distribution of clinical factors among patients with carcinomas and adenomas of the colon.

¹χ² test;

²Wilcoxon Rank Sum test. NSAID: Nonsteroidal ani-inflammatory drugs; BMI: Body mass index; NS: Not significant.

Table 2 Enzyme activities of glutathione S-transferase and uridine glucuronosyltransferase in the normal colon mucosa of patients with adenoma and carcinoma (mean ± SD)

Enzyme activities	Adenomas (n = 28)	Carcinomas (n = 20)	P-value (F-test)
GST (nmol/mg per minute)
Transversum	225 ± 104 (19)	237 ± 72 (18)	0.1342
Sigmoid	265 ± 152 (27)	232 ± 78 (19)	0.0046
Combined	268 ± 152 (28)	241 ± 69 (20)	0.0007
UGT (pmol mg per minute)
Transversum	231 ± 269 (17)	159 ± 122 (16)	0.0015
Sigmoid	170 ± 158 (23)	144 ± 96 (17)	0.0456
Combined	197 ± 200 (27)	150 ± 86 (19)	0.0005

Number of enzyme assays given in brackets. GST: Glutathione S-transferase; UGT: Uridine glucuronosyltransferase.

Table 3 Gender differences between glutathione s-transferase and uridine glucuronosyltransferase activities in the colon of patients with colon-neoplasia

	Male	Female	t-test	F-test
GST (combined)	258 ± 139 (36)	235 ± 68 ( 15)	0.54	0.006
Transversum	218 ± 94 (26)	251 ± 71 (13)	0.28	0.310
Sigmoid	267 ± 137 (34)	202 ± 75 (14)	0.10	0.020
UGT (combined)	198 ± 180 (34)	146 ± 99 (15)	0.30	0.020
Transversum	231 ± 238 (23)	153 ± 108 (12)	0.29	0.009
Sigmoid	168 ± 142 (29)	141 ± 110 (13)	0.54	0.360

Number of enzyme assays in brackets. For the t-test and the F-test P-values are indicated. GST: Glutathione S-transferase; UGT: Uridine glucuronosyltransferase.