Medical influences, surgical outcomes: Role of common medications on the risk of perforation from untreated diverticular disease

doi:10.3748/wjg.v19.i36.5947

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Sep 28, 2013 (publication date) through Jan 30, 2025

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Sep 28, 2013; 19(36): 5947-5952
Published online Sep 28, 2013. doi: 10.3748/wjg.v19.i36.5947

Table 1 Case-controls studies investigating the association of non-steroidal anti-inflammatory drugs, steroids, opioids, calcium channel blockers and perforated diverticular disease

Author	Country	Drugs	Patients (n)	Control group (n)	OR
Goh et al[20]	United Kingdom	NSAIDs	20	HC (600), DD (125)	2.1 (95%CI: 1.3-3.4) for HC
Goh et al[20]	United Kingdom	NSAIDs	20	HC (600), DD (125)	4.6 (95%CI: 1.7-12.5) for DD
Mpofu et al[25]	United Kingdom	NSAIDs	64	HC (320)	1.8 (95%CI: 0.96-3.4)
Corder et al[26]	United Kingdom	NSAIDs	-	DD	4.8 (95%CI: 1.6-14.8)
Humes et al[27]	United Kingdom	NSAIDs	899	HC (8980)	1.5 (95%CI: 1.01-2.3)
Piekarek et al[28]	Sweden	NSAIDs	54	DD (183)	3.6 (95%CI: 1.5-8.4)
Mpofu et al[25]	United Kingdom	Steroids	64	HC (320)	31.9 (95%CI: 6.4-159.2)
Corder et al[26]	United Kingdom	Steroids	-	DD	13.2 (95%CI: 1.81-96.5)
Humes et al[27]	United Kingdom	Steroids	899	HC (8980)	2.7 (95%CI: 1.6-4.6)
Piekarek et al[28]	Sweden	Steroids	54	DD (183)	28.3 (95%CI: 4.8-165.7)
Humes et al[27]	United Kingdom	Opioids	899	HC (8980)	2.2 (95%CI: 1.6-3.0)
Piekarek et al[28]	Sweden	Opioids	54	DD (183)	4.5 (95%CI: 1.7-12.2)
Morris et al[3]	United Kingdom	Ca²⁺	120	HC (480)	0.4 (95%CI: 0.2-0.9)
Humes et al[27]	United Kingdom	Ca²⁺	899	HC (8980)	0.54 (95%CI: 0.24-1.24)
Piekarek et al[28]	Sweden	Ca²⁺	54	DD (183)	0.14 (95%CI: 0.02-0.95)

NSAIDs: Non-steroidal anti-inflammatory drugs; Ca²⁺: Calcium-channels blockers; HC: Healthy control; DD: Non-perforated diverticular disease.

Citation: Gravante G, Yahia S. Medical influences, surgical outcomes: Role of common medications on the risk of perforation from untreated diverticular disease. World J Gastroenterol 2013; 19(36): 5947-5952
URL: https://www.wjgnet.com/1007-9327/full/v19/i36/5947.htm
DOI: https://dx.doi.org/10.3748/wjg.v19.i36.5947