Extracorporeal continuous portal diversion plus temporal plasmapheresis for “small-for-size” syndrome

Table 1 Hemodynamic parameters measured at baseline, immediately post-hepatectomy, 48 h post-hepatectomy and euthanasia (49 h post-hepatectomy)

	Systemic group	Portal group	P value
Body weight (kg)	22.4 ± 3.4	23.6 ± 3.6	0.910
Left trilobes (g)	381.2 ± 14.9	390.5 ± 15.8	0.840
ETL (g)	476.8 ± 18.4	487.0 ± 19.7	0.860
WRL (g)	412.1 ± 15.6	413.1 ± 20.4	0.790
ERL (g)	61.7 ± 3.8	63.8 ± 4.1	0.760
Proportion of ERL	12.8% ± 2.3%	13.1% ± 3.5%	0.870
Operation time (min)	110 ± 23	126 ± 28	0.450
Blood loss (mL)	41.7 ± 13.8	49.1 ± 16.1	0.730
PVF (mL/min per 100 g)
BAS	61.9 ± 9.6	64.1 ± 10.6	0.945
2 h PH	431.8 ± 36.6	238.8 ± 29.3	0.002
48 h PH	220.3 ± 21.1	152.3 ± 21.6	0.014
49 h PH	214.3 ± 26.1	227.4 ± 27.61	0.674
HAF (mL/min per 100 g)
BAS	19.4 ± 4.5	19.9 ± 4.1	0.921
2 h PH	6.1 ± 2.5	14.9 ± 2.5	0.003
48 h PH	7.9 ± 2.1	13.2 ± 4.2	0.002
EUT (49 h PH)	8.2 ± 2.4	11.6 ± 3.5	0.003
P/A
BAS	3.1 ± 0.2	3.2 ± 0.2	0.843
2 h PH	70.8 ± 8.1	16.0 ± 3.1	0.000
48 h PH	27.8 ± 6.6	11.5 ± 1.8	0.002
EUT (49 h PH)	26.1 ± 4.9	19.4 ± 4.61	0.001

All flow values are reported in mL/min per 100 g hepatic tissue. The data are expressed as mean ± SD. Estimated total liver weight = Weight of left trilobes × 100/80. ETL: Estimated total liver weight; WRL: Weight of resected liver; ERL: Estimated residual liver weight; PH: Post-hepatectomy; BAS: Baseline; EUT: Euthanasia; P/A: Portal-to-arterial flow ratio; PVF: Portal vein flow.

¹Extracorporeal continuous portal diversion was stopped for 1 h.

Table 2 Serial change in serum ammonia, alanine aminotransferase and total bilirubin levels in the two groups

	ALT (U/L)		TB (mmol/L)		Ammonia (μmol/L)
	Systemic	Portal	Systemic	Portal	Systemic	Portal
Pre	45.2 ± 12.1	51.3 ± 15.5	17.3 ± 4.1	16.4 ± 5.5	158.4 ± 57.5	164.3 ± 46.2
2 h	67.2 ± 23.4	61.7 ± 26.1	19.5 ± 6.1	18.6 ± 6.3	239.6 ± 61.8	193.7 ± 47.0
24 h	129.7 ± 35.2	78.6 ± 24.51	45.9 ± 8.5	28.4 ± 5.71	345.2 ± 59.5	210.3 ± 67.71
30 h	101.5 ± 23.2	67.2 ± 16.412	36.4 ± 7.4	25.8 ± 5.11	217.4 ± 51.8	131.7 ± 37.412
48 h	118.6 ± 31.4	74 ± 291	58.4 ± 9.0	38.3 ± 7.11	254.3 ± 49.7	180.1 ± 54.51

¹Indicates a significant difference between the two groups (P < 0.05); and

²Indicates a significant difference in levels before and after Plasmapheresis (P < 0.05). ALT: Alanine aminotransferase; TB: Total bilirubin.