Neuroendocrine carcinoma of the extrahepatic bile duct: Case report and literature review

Table 1 Neuroendocrine carcinoma of the extrahepatic bile ducts-review of the literature

No.	Ref.	Age (yr)	Sex	Histology	Location	Maximal dimension (cm)	Treatment	Follow-up information	Other findings
1	Sabanathan et al[2]	67	M	SCNEC	Bm	5	Palliative bypass and chemotherapy	Alive 6 mo
2	Miyashita et al[3]	85	F	SCNEC	Bi	3	Palliative bypass	DOD 5 mo after surgery
3	Kuraoka et al[4]	75	M	SCNEC	Bi	4.5	Resection	Alive 5 mo after surgery	Dysplasia
4	Hazama et al[5]	60	M	SCNEC	CBD	0.3	Neoadjuvant chemotherapy and resection	DOD 12 mo after surgery
5	Arakura et al[6]	70	F	SCNEC	Bm	3	Resection and chemotherapy	DOD 14 mo after surgery
6	Park et al[7]	60	F	SCNEC	Bs-Bm	3	Resection	DOD 5 mo after surgery
7	Thomas et al[8]	54	M	SCNEC	Bh-CBD	NA	Resection	Alive With Metastasis, 6 mo	Clonorchis sinensis infestation
8	Viana Miguel et al[9]	76	M	SCNEC	Bm	NA	Resection, chemotherapy and irradiation	Alive 5 mo after surgery	Gallstone
9	Jeon et al[10]	65	M	SCNEC	Bs-Bm	2	Presection and chemotherapy	DOD 12 mo after surgery
10	Nakai et al[11]	32	M	SCNEC	CBD	NA	NA, diagnosed by autopsy	NA
11	Arakura et al[12]	75	M	SCNEC	Bh, Bs, Bm, Bi	6.5	Chemotherapy and irradiation	DOD 10 mo after therapy
12	Hosonuma et al[13]	69	F	SCNEC	Bs-Bm	3	Biliary drainage	Alive 2 mo after biliary drainage
13	Okamura et al[14]	62	M	SCNEC	Bm	3	Preoperative chemotherapy, resection and irradiation	DOD 20 mo after surgery
14	Yamaguchi et al[15]	77	F	NEC	Bi	NA	Resection and chemotherapy	Alive 27 mo
15	van der Wal et al[16]	55	M	SCNEC + atypical carcinoid + AD	Bm	4	Resection	NA	Dysplasia/carcinoma in situ
16	Nishihara et al[17]	64	M	SCNEC + AD	Bh-Bs	1.9	Resection	Alive 8 mo after surgery
17	Yamamoto et al[18]	71	F	SCNEC + AD	Bh	6	Resection	DOD 7 mo after surgery	Common bile duct stones
18	Kim et al[19]	64	M	SCNEC + AD	Bm	3	Resection	Alive 30 d after surgery	Clonorchis sinensis infestation
19	Edakuni et al[20]	82	F	SCNEC + AD	Bm	6	Resection	Alive 45 mo after surgery
20	Kaiho et al[21]	66	F	SCNEC + AD	Bm	3.5	Resection and chemotherapy	DOD 8 mo after surgery
21	Sato et al[22]	68	M	LCNEC + AD	Bi	2	Resection and chemotherapy	DOD 3 mo after surgery
22	Demoreuil et al[23]	73	M	LCNEC + AD	Bh-Bs	3	Resection and chemotherapy	DOD 12 mo after surgery
23	Current report, 2013	76	M	LCNEC	Bh-Bs	5	Resection	DOD 21 d after surgery	Dysplasia, intestinal type

SCNEC: Small cell neuroendocrine carcinoma; NEC: Nneuroendocrine carcinoma, not otherwise specified; AD: Adenocarcinoma; LCNEC: Large cell neuroendocrine carcinoma; Bm: Mid portion of common bile duct; Bi: Inferior or distal common bile duct; CBD: Common bile duct, not otherwise specified; Bs; Superior or proximal common bile/hepatic duct; Bh: Hilar bile duct; DOD: Died of disease. N/A: Information not available; F: Female; M: Male.