Effects of propranolol or propranolol plus isosorbide-5-mononitrate on variceal pressure in schistosomiasis

doi:10.3748/wjg.v19.i26.4228

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Jul 14, 2013 (publication date) through Nov 21, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 14, 2013; 19(26): 4228-4233
Published online Jul 14, 2013. doi: 10.3748/wjg.v19.i26.4228

Table 1 Demographic profile of the study population

	PR group (n = 20)	PR + ISMN group (n = 20)	P value
Sex			0.619
Male	12	11
Female	8	9
Age (yr)	47.87 ± 15.16	44.14 ± 9.51	0.585
Child-Pugh grade			1.000
A	9	8
B	11	12
Child-Pugh score	8.87 ± 1.88	8.00 ± 1.63	0.358
Albumin (g/L)	30.63 ± 3.82	33.34 ± 5.30	0.271
Total bilirubin (μmol/L)	29.45 ± 17.02	25.11 ± 11.26	0.577
Prothrombin time (s)	16.80 ± 1.82	16.65 ± 1.59	0.875
VP (mmHg)	24.15 ± 6.05	25.69 ± 5.26	0.248
Varix grade			0.608
F2	10	9
F3	10	11
Red color signs	12	14	1.000

VP: Variceal pressure; PR: Propranolol; ISMN: Isosorbide-5-mononitrate.

Table 2 Effects of propranolol and propranolol plus isosorbide-5-mononitrate on variceal pressure, liver function and systemic hemodynamics in patients with 6 mo of follow-up

	PR		PR + ISMN
	Baseline	6 mo	Baseline	6 mo
(ΔVP)%	0	15.93 ± 8.37	0	6.05 ± 3.67^a
ALB (g/L)	30.63 ± 3.82	31.14 ± 3.08	33.34 ± 5.30	34.30 ± 5.09
TB (umol/L)	29.45 ± 17.02	27.26 ± 12.27	25.11 ± 11.26	26.74 ± 12.96
SBP (mmHg)	132 ± 20	124 ± 21^d	130 ± 19	125 ± 19^d
DBP (mmHg)	77 ± 10	72 ± 11^d	74 ± 10	70 ± 13^d

^aP < 0.05 vs PR group,

^dP < 0.01 vs baseline. (ΔVP)%: Percentage difference in variceal pressure from baseline; PR: Propranolol; ISMN: Isosorbide-5-mononitrate; ALB: Albumin; TB: Total bilirubin; SBP: Systolic blood pressure; DBP: Diastolic blood pressure.

Citation: Kong DR, Ma C, Wang M, Wang JG, Chen C, Zhang L, Hao JH, Li P, Xu JM. Effects of propranolol or propranolol plus isosorbide-5-mononitrate on variceal pressure in schistosomiasis. World J Gastroenterol 2013; 19(26): 4228-4233
URL: https://www.wjgnet.com/1007-9327/full/v19/i26/4228.htm
DOI: https://dx.doi.org/10.3748/wjg.v19.i26.4228