Brief Article
Copyright ©2013 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Jul 14, 2013; 19(26): 4228-4233
Published online Jul 14, 2013. doi: 10.3748/wjg.v19.i26.4228
Effects of propranolol or propranolol plus isosorbide-5-mononitrate on variceal pressure in schistosomiasis
De-Run Kong, Chao Ma, Min Wang, Jing-Guang Wang, Chen Chen, Lei Zhang, Jia-Hu Hao, Pan Li, Jian-Ming Xu
De-Run Kong, Jing-Guang Wang, Chen Chen, Lei Zhang, Pan Li, Jian-Ming Xu, Department of Gastroenterology, First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China
Chao Ma, Department of Gastroenterology, Fuyang Second People’s Hospital, city, Fuyang 236015, Anhui Province, China
Min Wang, Department of Medicine, Tongling Vocational Technology College, Tongling 244003, Anhui Province, China
Jia-Hu Hao, Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei 230032, Anhui Province, China
Author contributions: Kong DR, Ma C and Wang M contributed equally to this work; Kong DR, Ma C and Wang M were involved in acquisition, analysis and interpretation of data, and drafting of the manuscript; Wang JG, Li P and Chen C were involved in acquisition, analysis and interpretation of data; Zhang L provided technical support and was involved in study supervision; Hao JH was involved in study design, statistical analysis and study supervision; Xu JM was involved in study design, analysis and interpretation of data, critical revision of the manuscript and study supervision.
Supported by Educational and Health Department of Anhui Province, No. KJ2010A158, KJ2012Z189, 2010B018; General Program of National Natural Science Foundation of China, No. 81070337, 81271736
Correspondence to: Jian-Ming Xu, MD, Department of Gastroenterology, First Affiliated Hospital of Anhui Medical University, Jixi Road 218, Hefei 230022, Anhui Province, China. xjm1017@yahoo.com.cn
Telephone: +86-551-62922105 Fax: +86-551-65120742
Received: November 20, 2012
Revised: May 22, 2013
Accepted: June 5, 2013
Published online: July 14, 2013
Processing time: 234 Days and 18.7 Hours
Core Tip

Core tip: The results of the present study suggested that the combination of propranolol and isosorbide-5-mononitrate was more effective than propranolol alone in decreasing variceal pressure. This drug combination will reduce the rate of bleeding in patients with schistosomiasis, high-risk esophageal varices and no previous history of variceal bleeding.