Human liver tissue metabolic profiling research on hepatitis B virus-related hepatocellular carcinoma

Table 1 Metabolite identification results

m/z	Retention time (min)	Metabolite	Adduct2	Content3
				Normal/adjacent	Adjacent/tumor	Normal/tumor
453.345	4.39632	Sitosterol-β	M + K [1+]	Upa		Upa
166.086	1.05638	L-phenylalanine1	M + H [1+]		Upa	Upb
520.341	6.84401	LysoPC [18:2 (9Z, 12Z)]	M + H [1+]		Upa	Upb
258.111	0.77819	Glycerophosphocholine1	M + H [1+]		Upb	Upb
476.276	7.10121	LysoPE [18:3 (9Z, 12Z, 15Z)/0:0]	M + H [1+]		Upa	Upb
450.322	5.88844	Chenodeoxycholic acid glycine conjugate1	M + H [1+]		Upb	Upb
568.342	6.78248	LysoPC [22:6 (4Z, 7Z, 10Z, 13Z, 16Z, 19Z)]	M + H [1+]		Upa	Upb
212.02	5.54796	Quinaldic acid	M + K [1+]	Upb		Upa
456.406	8.78787	Arachidyl carnitine	M + H [1+]		Downa	Downb
504.308	7.89672	LysoPE (18:0/0:0)	M + Na [1+]		Upa	Upa
546.357	7.08546	LysoPC (18:0)1	M + Na [1+]		Upa	Upb
566.323	6.82403	LysoPC [20:4 (5Z, 8Z, 11Z, 14Z)]	M + Na [1+]		Upb	Upb
230.249	6.09076	Tetradecanal	M + NH4 [1+]		Downb	Downb
282.28	9.02044	Oleamide	M + H [1+]	Downb		Downb

¹Metabolites identified by standard comparison;

²Ionospheric models of mass spectrometry cationic scanning;

³Comparison of characteristic metabolites’ integral peak area in the three groups.

^aP < 0.05,

^bP < 0.01 vs samples related non-parametric test. lysoPC: Lysophosphatidylcholine; lysoPE: Lysophosphatidylethanolamines.