Brief Article
Copyright ©2013 Baishideng Publishing Group Co.
World J Gastroenterol. Jun 7, 2013; 19(21): 3249-3254
Published online Jun 7, 2013. doi: 10.3748/wjg.v19.i21.3249
Table 1 Patient characteristics
PatientAge (yr)Disease stage> G1 radiotherapySurgicalSurgical stageOutcome at 2 yrTumor purityMean RNA content (μg)
toxicitytoxicityof follow-upin biopsiesPre-RT biopsiesEarly-RT biopsies
166uT2NxNoNoypT2N0NED100%18.019.7
255uT3N1NoNoypT4N1NED100%27.012.6
384uT3N1NoNoypT3N1M1100%21.035.8
478uT3N1NoNoypT2N0NED100%37.128.7
560uT3N0NoNoypT3N1NED100%20.019.4
667uT3N0NoNoypT2N1NED100%14.219.9
Table 2 Up- or down-regulated genes in rectal cancer biopsies
FoldFalse discovery rateIDGene titleSymbol
Up-regulated genes
2.6490AI827789Anterior gradient homolog 3 (Xenopus)AGR3
3.4270AA743462--
2.5240NM_006472Thioredoxin interacting proteinTXNIP
5.5140AB018305Spondin 1, extracellular matrix proteinSPON1
2.957.551NM_152315Family with sequence similarity 55, AFAM55A
3.2897.551AL536553Neural precursor cell expressed, developmentally down-regulated 4-likeNEDD4L
2.6847.551AF055009cAMP responsive element binding protein 3-like 1CREB3L1
3.1117.551AL137063A kinase (PRKA) anchor protein 7AKAP7
2.7177.551AF266504Chemokine (C-C motif) ligand 28CCL28
2.5468.39BF589413FERM domain containing 3FRMD3
2.6378.39AA554045Polypeptide N-acetylgalactosaminyltransferase 12GALNT12
3.0478.39NM_030926Integral membrane protein 2CITM2C
2.7758.39AW026379Tumor necrosis factor receptor superfamily, member 11aTNFRSF11A
2.6098.39U38654RAB27A, member RAS familyRAB27A
2.6298.39NM_003570Cytidine monophosphate-N-acetylneuraminic acid hydroxylase pseudogeneCMAH
2.5218.58AV728268Chromosome 11 open reading frame 32C11orf32
2.5798.58NM_016929Chloride intracellular channel 5CLIC5
2.54110.487NM_016548Golgi membrane protein 1GOLM1
2.72810.487AW162846Calcium/calmodulin-dependent protein kinase II inhibitor 1CAMK2N1
2.80610.487AI659927prostate androgen-regulated mucin-like protein 1PARM1
2.89610.487NM_024709Chromosome 1 open reading frame 115C1orf115
3.33310.487NM_005629Solute carrier family 6 member 8SLC6A8
2.86910.487NM_019062Ring finger protein 186RNF186
3.17410.487AK025181Intestine-specific homeoboxISX
3.96810.487AB007899Neural precursor cell expressed, developmentally down-regulated 4-likeNEDD4L
8.210.487NM_001873Carboxypeptidase ECPE
4.84510.487NM_014479ADAM-like, decysin 1ADAMDEC1
2.5610.487BF195709Calpain 5CAPN5
2.60110.487NM_014456Programmed cell death 4PDCD4
2.93110.787AW971415cDNA clone IMAGE:5745639-
2.78710.787NM_005173ATPase, Ca++ transporting, ubiquitousATP2A3
Down-regulated genes
0.2658.58AI378647Coagulation factor II (thrombin) receptor-like 2F2RL2
0.3568.58BG200951Pvt1 oncogene homolog, MYC activatorPVT1
0.32210.787AL109839Poly(A) binding protein, cytoplasmic 1-likePABPC1L
0.35610.787NM_005978S100 calcium binding protein A2S100A2
0.37310.787AL041761Transcribed locus-
0.3810.787D86983Peroxidasin homolog (Drosophila)PXDN