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World J Gastroenterol. Jun 7, 2013; 19(21): 3249-3254
Published online Jun 7, 2013. doi: 10.3748/wjg.v19.i21.3249
Published online Jun 7, 2013. doi: 10.3748/wjg.v19.i21.3249
Early dynamic transcriptomic changes during preoperative radiotherapy in patients with rectal cancer: A feasibility study
Stephane Supiot, Marc-Andre Mahé, Emmanuel Rio, Department of Radiation Oncology, Institut de Cancérologie de l’Ouest René Gauducheau, 44800 Nantes-St-Herblain, France
Stephane Supiot, Wilfried Gouraud, Loïc Campion, Pascal Jezéquel, Josiane Charrier, Michel Chérel, INSERM U892, Centre de Recherche en Cancérologie Nantes-Angers, University of Nantes, 44000 Nantes, France
Bruno Buecher, Marie-Francoise Heymann, Centre Hospitalier Universitaire, 44000 Nantes, France
Michel Chérel, Department of Nuclear Medicine, Institut de Cancérologie de l’Ouest René Gauducheau, 44800 Nantes-Saint Herblain, France
Author contributions: Supiot S, Jezéquel P, Buecher B, Mahé MA and Chérel M designed the research; Supiot S, Jezéquel P and Chérel M performed the research; Supiot S, Buecher B, Charrier J, Heymann MF, Mahé MA, Rio E and Chérel M contributed new reagents and analytic tools; Supiot S, Gouraud W, Campion L, Jezéquel P, Heymann MF and Chérel M analyzed the data; Supiot S, Gouraud W, Campion L and Chérel M wrote the paper.
Supported by Ligue Contre le Cancer, Programme Hospitalier de Recherche Clinique (20-R6)
Correspondence to: Michel Chérel, PhD, INSERM U892, Centre de Recherche en Cancérologie Nantes-Angers, University of Nantes, 8 quai Moncousu - BP 70721, 44000 Nantes, France. michel.cherel@univ-nantes.fr
Telephone: +33-2-28080245 Fax: +33-2-28080204
Received: December 20, 2012
Revised: February 22, 2013
Accepted: March 21, 2013
Published online: June 7, 2013
Processing time: 166 Days and 19.3 Hours
Revised: February 22, 2013
Accepted: March 21, 2013
Published online: June 7, 2013
Processing time: 166 Days and 19.3 Hours
Core Tip
Core tip: To develop novel biomarkers of radiotherapy for rectal cancer, we measured gene expression profiles on biopsies taken before and during preoperative radiotherapy in a pilot study. Microarray analysis showed that preoperative radiotherapy significantly up-regulated 31 genes and down-regulated 6 genes, involved in protein metabolism, ion transport, transcription, signal transduction, cell adhesion, immune response and apoptosis. Micro-arrays could efficiently assess early transcriptomic changes during preoperative radiotherapy for rectal cancer. This may help better understand tumor radioresistance.