Difference in DRB1* gene polymorphisms between Han and Uyghur ulcerative colitis patients in China

Table 1 The 5’ amplification primer mix included the following primers

5'-CCACAGCACGTTTCTTGGAGTACTCTA-3'

5'-CCAGTTTCTTGTGGCAGCTTAAGTT-3'

5'-TCGTTCCTGTGGCAGGGTAAGTATA-3'

5'-AGCCGTTTCTTGAAGCAGGATAAGTT-3'

5'-CCAAGCACGTTTCTTGGAGGAGG-3'

5'-TCGTTCCTGTGGCAGCCTAAGA-3'

5'-AGCCGTTTCTTGGAGCAGGTTAAAC-3'

Table 2 Clinical characteristics of the study subjects n (%)

Characteristics	UC patients	Controls	P value
Total number (n)	102	310
Han	53	161	0.998
Uyghur	49	149	0.998
Gender, M/F	47/55	137/173	0.740
Age of onset1, yr	48.07 ± 15.83	47.37 ± 14.49	0.801
Extensive colitis (Han)	20 (38)
Extensive colitis (Uyghur)	30 (61)
Distal colitis (Han)	33 (62)
Mild and intermediate	47 (89)
Severe	6 (11)
Distal colitis (Uyghur)	19 (39)
Mild and intermediate	40 (82)
Severe	9 (18)

¹Data are expressed as mean ± SD. UC: Ulcerative colitis.

Table 3 Genotypic association between DRB1* variants and ulcerative colitis in the Han and Uyghur population

	Han UC (n = 53)		Controls (n = 161)		χ2	P value	Uyghur UC (n = 49)		Controls (n = 149)		χ2	P value
	n (%)	Genotype frequencies	n (%)	Genotype frequencies			n (%)	Genotype frequencies	n (%)	Genotype frequencies
HLA-DRB1**01	0	0	0	0			1 (2.04)	0.010	0	0	3.056	0.247
HLA-DRB1**03	6 (11.32)	0.058	36 (22.36)	0.119	3.081	0.110	8 (16.33)	0.085	30 (20.13)	0.106	0.345	0.678
HLA-DRB1**04	4 (7.55)	0.039	4 (2.49)	0.013	2.840	0.106	5 (10.21)	0.052	4 (2.69)	0.014	4.805	0.043
HLA-DRB1**08	3 (5.66)	0.029	9 (5.59)	0.028	0.000	1.000	0	0	15 (10.07)	0.052	5.337	0.024
HLA-DRB1**11	11 (20.76)	0.110	18 (11.18)	0.058	3.120	0.103	8 (16.33)	0.085	39 (26.18)	0.141	1.975	0.180
HLA-DRB1**12	22 (41.51)	0.235	78 (48.45)	0.282	0.771	0.429	13 (26.53)	0.143	51 (34.23)	0.189	0.999	0.380
HLA-DRB1**13	1 (1.89)	0.009	9 (5.59)	0.028	1.228	0.457	7 (14.29)	0.074	6 (4.03)	0.022	6.326	0.019
HLA-DRB1**14	6 (11.32)	0.058	7 (4.35)	0.023	3.398	0.093	7 (14.29)	0.074	4 (2.69)	0.014	9.458	0.006

UC: Ulcerative colitis.