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©2013 Baishideng Publishing Group Co.
World J Gastroenterol. Apr 21, 2013; 19(15): 2404-2411
Published online Apr 21, 2013. doi: 10.3748/wjg.v19.i15.2404
Published online Apr 21, 2013. doi: 10.3748/wjg.v19.i15.2404
Table 1 Relationship between Twist2 expression and clinicopathological characteristics n (%)
Characteristics | Total | Twist2 expression | P value | |
Negative | Positive | |||
Gender | ||||
Female | 52 (55.9) | 18 (66.7) | 34 (51.5) | 0.1821 |
Male | 41 (44.1) | 9 (33.3) | 32 (48.5) | |
Age | ||||
< 59 | 41 (44.1) | 13 (48.1) | 28 (42.4) | 0.6141 |
≥ 59 | 52 (55.9) | 14 (51.9) | 38 (57.6) | |
T-stage | ||||
T1-2 | 17 (18.3) | 5 (18.5) | 12 (18.2) | 1.0002 |
T3-4 | 76 (81.7) | 22 (81.5) | 54 (81.8) | |
N-stage | ||||
N0 | 52 (55.9) | 17 (63.0) | 35 (53.0) | 0.3811 |
N1-2 | 41 (44.1) | 10 (37.0) | 31 (47.0) | |
M-stage | ||||
M0 | 52 (55.9) | 17 (63.0) | 35 (53.0) | 0.3811 |
M1 | 41 (44.1) | 10 (37.0) | 31 (47.0) | |
Tumor differentiation | ||||
Moderate/good | 83 (89.2) | 26 (96.3) | 57 (86.4) | 0.2712 |
Poor | 10 (10.8) | 1 (3.7) | 9 (13.6) | |
Vascular invasion | ||||
No | 56 (60.2) | 17 (63.0) | 39 (59.1) | 0.7291 |
Yes | 37 (39.8) | 10 (37.0) | 27 (40.9) | |
Tumor location | ||||
Rectum | 19 (20.4) | 4 (14.8) | 15 (22.7) | 0.3901 |
Colon | 74 (79.6) | 23 (85.2) | 51 (77.3) | |
CEA level (ng/mL) | ||||
≤ 5 | 48 (51.6) | 12 (4.4) | 36 (54.5) | 0.3761 |
> 5 | 45 (48.4) | 15 (55.6) | 30 (45.5) |
Table 2 Relationship between Twist2 and E-cadherin expression n (%)
Twist2 expression | E-cadherin expression | P value | |
Preserved (n = 50) | Reduced (n = 43) | ||
Positive (n = 66) | 31 (47.0) | 35 (53.0) | 0.040 |
Negative (n = 27) | 19 (70.4) | 8 (29.6) |
Table 3 Univariate and multivariate analysis of the prognostic factors for overall survival
Prognostic factors | Univariate analysis | Multivariate analysis | ||||
HR | 95%CI | P value | HR | 95%CI | P value | |
Gender | ||||||
Female | 1 | |||||
Male | 1.011 | 0.490-2.085 | 0.977 | NA | NA | NA |
Age | ||||||
< 59 | 1 | |||||
≥ 59 | 1.579 | 0.750-3.326 | 0.229 | NA | NA | NA |
T-stage | ||||||
T1-2 | 1 | |||||
T3-4 | 1.118 | 0.493-2.534 | 0.789 | NA | NA | NA |
N-stage | ||||||
N0 | 1 | |||||
N1-2 | 2.172 | 1.056-4.468 | 0.035 | NS | NS | NS |
M-stage | ||||||
M0 | 1 | 1 | ||||
M1 | 6.324 | 2.659-15.041 | < 0.001 | 7.694 | 2.927-20.224 | < 0.001 |
Tumor differentiation | ||||||
Moderate/good | 1 | |||||
Poor | 1.290 | 0.491-3.384 | 0.229 | NA | NA | NA |
Vascular invasion | ||||||
No | 1 | |||||
Yes | 3.398 | 1.601-7.211 | 0.001 | NS | NS | NS |
Tumor location | ||||||
Rectum | 1 | |||||
Colon | 1.188 | 0.517-2.729 | 0.685 | NA | NA | NA |
CEA level (ng/mL) | ||||||
≤ 5 | 1 | |||||
> 5 | 3.173 | 1.475-6.827 | 0.003 | NS | NS | NS |
Twist2 expression | ||||||
Negative | 1 | 1 | ||||
Positive | 4.964 | 1.181-20.863 | 0.029 | 5.744 | 1.347-24.298 | 0.018 |
Table 4 Univariate and multivariate analysis of the prognostic factors for disease-free survival
Prognostic factors | Univariate analysis | Multivariate analysis | ||||
HR | 95%CI | P value | HR | 95%CI | P value | |
Gender | ||||||
Female | 1 | |||||
Male | 1.001 | 0.587-1.706 | 0.998 | NA | NA | NA |
Age | ||||||
< 59 | 1 | |||||
≥ 59 | 1.060 | 0.621-1.809 | 0.831 | NA | NA | NA |
T-stage | ||||||
T1-2 | 1 | |||||
T3-4 | 1.258 | 0.833-1.899 | 0.276 | NA | NA | NA |
N-stage | ||||||
N0 | 1 | 1 | ||||
N1-2 | 2.511 | 1.468-4.295 | 0.001 | 2.149 | 1.226-3.767 | 0.008 |
M-stage | ||||||
M0 | 1 | 1 | ||||
M1 | 11.737 | 5.442-25.313 | < 0.001 | 10.907 | 4.937-24.096 | < 0.001 |
Tumor differentiation | ||||||
Moderate/good | 1 | |||||
Poor | 1.140 | 0.537-2.418 | 0.733 | NA | NA | NA |
Vascular invasion | ||||||
No | 1 | |||||
Yes | 3.246 | 1.874-5.625 | < 0.001 | NS | NS | NS |
Tumor location | ||||||
Rectum | 1 | |||||
Colon | 1.557 | 0.810-2.992 | 0.184 | NA | NA | NA |
CEA level (ng/mL) | ||||||
≤ 5 | 1 | |||||
> 5 | 2.958 | 1.692-5.172 | < 0.001 | NS | NS | NS |
Twist2 expression | ||||||
Negative | 1 | 1 | ||||
Positive | 2.632 | 1.184-5.809 | 0.017 | 3.264 | 1.455-7.375 | 0.004 |
- Citation: Yu H, Jin GZ, Liu K, Dong H, Yu H, Duan JC, Li Z, Dong W, Cong WM, Yang JH. Twist2 is a valuable prognostic biomarker for colorectal cancer. World J Gastroenterol 2013; 19(15): 2404-2411
- URL: https://www.wjgnet.com/1007-9327/full/v19/i15/2404.htm
- DOI: https://dx.doi.org/10.3748/wjg.v19.i15.2404