Yu H, Jin GZ, Liu K, Dong H, Yu H, Duan JC, Li Z, Dong W, Cong WM, Yang JH. Twist2 is a valuable prognostic biomarker for colorectal cancer. World J Gastroenterol 2013; 19(15): 2404-2411 [PMID: 23613636 DOI: 10.3748/wjg.v19.i15.2404]
Corresponding Author of This Article
Jia-He Yang, MD, PhD, Department of Laparoscopy, Eastern Hepatobiliary Surgery Hospital, the Second Military Medical University, No. 225, Changhai Road, Shanghai 200438, China. ehbhjhyang@163.com
Research Domain of This Article
Research & Experimental Medicine
Article-Type of This Article
Brief Article
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Table 2 Relationship between Twist2 and E-cadherin expression n (%)
Twist2 expression
E-cadherin expression
P value
Preserved (n = 50)
Reduced (n = 43)
Positive (n = 66)
31 (47.0)
35 (53.0)
0.040
Negative (n = 27)
19 (70.4)
8 (29.6)
Table 3 Univariate and multivariate analysis of the prognostic factors for overall survival
Prognostic factors
Univariate analysis
Multivariate analysis
HR
95%CI
P value
HR
95%CI
P value
Gender
Female
1
Male
1.011
0.490-2.085
0.977
NA
NA
NA
Age
< 59
1
≥ 59
1.579
0.750-3.326
0.229
NA
NA
NA
T-stage
T1-2
1
T3-4
1.118
0.493-2.534
0.789
NA
NA
NA
N-stage
N0
1
N1-2
2.172
1.056-4.468
0.035
NS
NS
NS
M-stage
M0
1
1
M1
6.324
2.659-15.041
< 0.001
7.694
2.927-20.224
< 0.001
Tumor differentiation
Moderate/good
1
Poor
1.290
0.491-3.384
0.229
NA
NA
NA
Vascular invasion
No
1
Yes
3.398
1.601-7.211
0.001
NS
NS
NS
Tumor location
Rectum
1
Colon
1.188
0.517-2.729
0.685
NA
NA
NA
CEA level (ng/mL)
≤ 5
1
> 5
3.173
1.475-6.827
0.003
NS
NS
NS
Twist2 expression
Negative
1
1
Positive
4.964
1.181-20.863
0.029
5.744
1.347-24.298
0.018
Table 4 Univariate and multivariate analysis of the prognostic factors for disease-free survival
Prognostic factors
Univariate analysis
Multivariate analysis
HR
95%CI
P value
HR
95%CI
P value
Gender
Female
1
Male
1.001
0.587-1.706
0.998
NA
NA
NA
Age
< 59
1
≥ 59
1.060
0.621-1.809
0.831
NA
NA
NA
T-stage
T1-2
1
T3-4
1.258
0.833-1.899
0.276
NA
NA
NA
N-stage
N0
1
1
N1-2
2.511
1.468-4.295
0.001
2.149
1.226-3.767
0.008
M-stage
M0
1
1
M1
11.737
5.442-25.313
< 0.001
10.907
4.937-24.096
< 0.001
Tumor differentiation
Moderate/good
1
Poor
1.140
0.537-2.418
0.733
NA
NA
NA
Vascular invasion
No
1
Yes
3.246
1.874-5.625
< 0.001
NS
NS
NS
Tumor location
Rectum
1
Colon
1.557
0.810-2.992
0.184
NA
NA
NA
CEA level (ng/mL)
≤ 5
1
> 5
2.958
1.692-5.172
< 0.001
NS
NS
NS
Twist2 expression
Negative
1
1
Positive
2.632
1.184-5.809
0.017
3.264
1.455-7.375
0.004
Citation: Yu H, Jin GZ, Liu K, Dong H, Yu H, Duan JC, Li Z, Dong W, Cong WM, Yang JH. Twist2 is a valuable prognostic biomarker for colorectal cancer. World J Gastroenterol 2013; 19(15): 2404-2411