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©2013 Baishideng Publishing Group Co.
World J Gastroenterol. Apr 21, 2013; 19(15): 2313-2318
Published online Apr 21, 2013. doi: 10.3748/wjg.v19.i15.2313
Published online Apr 21, 2013. doi: 10.3748/wjg.v19.i15.2313
Table 1 Case reports of hyposplenism-related infections in patients with celiac disease
Ref. | No. of cases | Type of infection | Supplementary findings |
Corazza et al[23] | 1 | Pneumoccoccal pneumonia | Splenic atrophy |
Matuchansky et al[24] | 2 | Pneumococcal pneumonia, infectious pericarditis | Splenic atrophy, MLNC |
O’Donoghue[25] | 1 | Pneumococcal septicemia | Splenic atrophy |
Logan et al[26] | 2 | Pneumococcal meningitis, septicemia by Salmonella | Splenic atrophy |
Stevens et al[27] | 3 | Lung abscesses by Staphyloccus and Klebsiella | Splenic atrophy |
Howat et al[28] | 2 | Fatal chest infection, septicemia | Splenic atrophy, MLNC |
Harmon et al[29] | 1 | Septicemia by Klebsiella | Splenic atrophy |
Table 2 Traditional polysaccharide and new conjugate anti-pneumococcal vaccines used in the prophylactic management of asplenic/hyposplenic patients
Vaccine | Brand name | Structure | Mechanism | Serotype | Indication |
PPV23 | Pneumovax® | Polysaccharide | T-cell independent | 1, 2, 3, 4, 5, 6B, 7F, 8, 9N, 9V, 10A, 11A, 12F, 14, 15B, 17F, 18C, 19A, 19F, 20, 22F, 23F, 33F | Asplenic or hyposplenic adults Asplenic or hyposplenic children > 5 yr |
PCV13 | Prevnar® | Protein-conjugate (CRM197 protein) | T-cell dependent | 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, 23F | Asplenic or hyposplenic children < 5 yr |
Table 3 Celiac patients in whom splenic function should be assessed
Patients with complications (RCD, UJI, EATL, collagenous sprue) |
Patients with concomitant autoimmune disorders |
Patients with old age at diagnosis |
Patients with previous history of major infections/sepsis and/or thromboembolism |
Patients with mesenteric lymph node cavitation and/or splenic atroph |
- Citation: Di Sabatino A, Brunetti L, Carnevale Maffè G, Giuffrida P, Corazza GR. Is it worth investigating splenic function in patients with celiac disease? World J Gastroenterol 2013; 19(15): 2313-2318
- URL: https://www.wjgnet.com/1007-9327/full/v19/i15/2313.htm
- DOI: https://dx.doi.org/10.3748/wjg.v19.i15.2313