Hepatocellular carcinoma in a non-cirrhotic patient with Wilson's disease

Table 1 Synopsis of patients with hepatocellular carcinoma and Wilson’s disease

Ref.	Sex	WD-age (yr)	HCC-age (yr)	Cirrhosis	Medical therapy	Invasive therapy	Status
Guan et al[2]	Female	23	27	Yes	Penicillamin	Hepatic resection	Alive
Iwadate et al[3]	Male	17	23	Yes	Penicillamin, low copper diet	-	Dead
Lowette et al[4]	-	-	-	Yes	Penicillamin	Transplant	Alive
Ikegawa et al[5]	Male	28	37	Yes	Penicillamin, zinc acetate dehydrate	Radiofrequency ablation	Alive
Kumagi et al[6]	Male	26	66	Yes	Penicillamin, transplant	Transcatheter arterial chemoembolisation	Dead
Kumagi et al[6]	Male	27	36	Yes	Penicillamin, transplant	-	Dead
Kumagi et al[6]	Male	27	46	Yes	Penicillamin	-	Alive
Lygren et al[15]	Male	15	16	Yes	-	-	Dead
Girard et al[16]	Male	22	41	Yes	Penicillamin	-	Dead
Kamakura et al[17]	Male	26	32	Yes	Penicillamin	-	Dead
Terao et al[18]	Male	29	40	Yes	Penicillamin, dimercaprol potassium sulfate	-	Dead
Wilkinson et al[19]	Male	31	41	Yes	Penicillamin	-	Dead
Buffet et al[20]	Male	45	57	Yes	Penicillamin	-	Dead
Imhof et al[21]	Male	18	40	-	Penicillamin	Hepatic resection	Alive
Madden et al[22]	Male	61	61	Yes	Penicillamin	-	Dead
Polio et al[23]	Male	32	33	Yes	Penicillamin, low copper diet	Chemotherapy	Dead
Cheng et al[24]	Female	39	72	Yes	Penicillamin, dimercaprol potassium sulfate	-	Dead
Agret et al[25]	Male	73	73	Yes	-	-	Dead
Walshe et al[26]	Male	8	46	Yes	Penicillamin	Transplant	Alive
Walshe et al[26]	Male	11	42	Yes	Penicillamin	-	Dead
Kumagi et al[27]	Male	66	66	Yes	-	Transcatheter arterial chemoembolisation	Dead
Ozçay et al[28]	Male	-	13	Yes	Penicillamin	Transplant	Alive
Aydinli et al[29]	Male	22	22	Yes	-	Radiofrequency ablation, transplant	Alive
Xu et al[30]	Male	29	29	Yes	-	Transcatheter arterial chemoembolisation, transplant	Alive
Reyes et al[31]	Male	59	59	Yes	-	-	Dead
Emlakçioglu et al[32]	Female	30	50	-	Penicillamin	Transcatheter arterial chemoembolisation	Alive
Ikubo et al[33]	Female	28	54	Yes	Penicillamin, pyridoxal-phosphate	Hepatic resection	Alive
Savas et al[34]	Male	6	12	Yes	Penicillamin, low copper diet	Transplant	Alive

WD: Wilson’s disease; HCC: Hepatocellular carcinoma diagnosis.